Aim. The aim of research was to study various methods of basic soil cultivation and a domestic wastewater silt sludge application which could possibility be directed to soil fertility saving and increase in crop yields.Materials and Methods. The object of research was a safflower variety called Alexandrite. Experimental variants were carried out according to a 4-fold repetition. Experiment installation, observations and accounting were carried out in accordance with the field experiment methodology named after B.A. Dospehov.Results. Field research was undertaken in order to study the various methods of a basic tillage and a domestic wastewater silt sludge application possibility under arid conditions of the Volgograd region on light chestnut solonetz soils. The amino acid composition of safflower (Carthamus tinctorius) seeds has been estimated. The data from the study of soil microbiological activity and the effect of non-traditional fertilizers on the increase in the activity of soil biota are presented. The crop yields and economic evaluation of the Carthamus tinctorius cultivation were determined.Conclusion. Modern resource-saving soil cultivation technologies and nontraditional fertilizers are required to: maintain the fertility of slightly humus soils in this arid climate zone, increase amino acids levels in plants, increase soil biological activity, as well to increase safflower crop yields. The proposed technical solutions, employing Rancho chisel tillage with as the basic tillage together with the introduction of non-traditional fertilizers-meliorants, provides structural restoration of soil aggregates, intensification of the humus formation process, increase in soil microbiological activity and - as a result - an increase in the yield of the cultivated Carthamus tinctorius crop.