The subject of research in the article is the technological security of Russia, which is acquiring particular relevance in the context of growing geopolitical tensions. Special attention is paid to technological sovereignty as a significant factor in ensuring the country's technological security in the context of unprecedented sanctions. In line with this current topic, the goal is to develop a number of significant industrial policy measures that will make it possible to strengthen the systematic regulation of technological safety in Russia in the context of sanctions. The novelty of the research lies in the substantiation and development of four groups of systemic measures aimed at ensuring consistency, coherence, diversification and balance of regulatory influences when solving technological safety problems. The first group of proposed measures affects the Concept of Technological Development of the Russian Federation. Their implementation will improve the consistency of the Concept with existing strategic planning documents and eliminate identified logical inconsistencies through the use of a specially developed structural and logical design. The second group of measures relates to the formation of feedback, which makes it possible to adjust priorities and distribute government funding among government support options, taking into account assessments of business preferences. The third group of measures is focused on ensuring diversification and balance of external sources of technology, which allows reducing the risks of dependence on one partner and thereby increasing the country’s technological security. The fourth group of measures is aimed at ensuring diversification and balance of domestic sources of technology. The need for a combination of adaptation (urgent) and long-term measures of state support for technological projects is substantiated. In general, the proposed measures will help strengthen the consistency and improve the quality of state regulation in the field of ensuring Russia’s technological security under sanctions.