Nowadays, food safety problems have occurred frequently, and how to ensure food quality safety has become the focus of attention of the whole world. While computer information technology has become a necessary means to control food quality safety along with the continuous improvement of information degree. Computer information technology is the general term mainly used for the management and processing of information, including acquisition, processing, expression, communication, management and evaluation of information. In this paper, the application of computer information technology applied in food industry at home and abroad was mainly summarized, including query and retrieval related information of food science, stimulation of the production process to effectively control the potential risk factors, fast calculation in the process of food production and consumption, network platform design of sensory evaluation instead of complex manual work, and realization the whole process of full traceability for food industrial chain, so as to provide effective supervision channels for the government, establish food industrial traceability system, improve the information degree in food management and play the role of information technology in food safety management and realize the value.