Healthcare workers (HCWs) are at heightened risk of occupational exposure to HIV due to their frequent interaction with blood and bodily fluids. This exposure led to potential HIV transmission if not managed promptly and effectively. This review provided a comprehensive examination of the risks associated with HIV exposure among HCWs, exploring the prevalence of such incidents, and evaluating current prevention and management strategies. Key risks included needlestick injuries and blood splashes, with prevalence varying significantly by region, particularly in areas with high HIV burden. Prevention strategies encompassed adherence to standard precautions, use of safety-engineered devices, comprehensive training, and the provision of post-exposure prophylaxis (PEP). Effective management involved immediate post-exposure assessment, timely administration of PEP, regular follow-up care, and access to counseling services. The review synthesizes recent research and clinical evidence, utilizing a systematic analysis of literature and guidelines to inform best practices in HIV risk management for HCWs. By addressing these strategies, the review aimed to enhance safety protocols and improve health outcomes within healthcare settings. Keywords: Occupational Exposure, Healthcare Workers, HIV Prevention, Post-Exposure Prophylaxis (PEP), Infection Control.
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