Safety Aspects Research Articles

Development and Usage of Refrigeration and Air Conditioning Trainer for Beginners

This study aimed to evaluate the effectiveness of the developed trainer for refrigeration, which is constructed through the specifications of the users. It focuses on the primary usage, functionality, applicability, and safety aspects of the project, as well as how it effectively assists people through innovative means. The project is tested out of 15 respondents that has knowledge regarding refrigeration and air-conditioning, enough to understand the flow of the project its material used, functions, usage and how it works. Based on the comprehensive evaluation the following key findings have emerged. Functionality Excellence, The prototype trainer demonstrates exceptional functionality, achieving an excellent rating. This indicates a high level of effectiveness in performing various task/activity in refrigeration works. Applicability of the device exhibits versatility with high ratings. Its adaptability to diverse environments underscores its broad applicability.User safety of The trainer dependability is further enhanced by the removal of potentially hazardous materials and the addition of overload protection.

Analysis of Implementation Delay in Road Construction Project (A Case Study of Road Improvement Project in Jayapura Regency)

Planning and control over time and cost are important parts of overall construction project management. Work achievement of a project can be assessed through its quality, time, cost and safety aspects. So, in completing work project, time and cost incurred are aspects that must be continously measured for its deviation from the original plan. İn this study, time and cost deviations makes the management of road improvement project of Jayapura Regency getting worse. By employing several project performance indicators such as time and cost, it is possible to take preventative steps to make the road improvement project of Jayapura Regency can be proceed as planned. The research method applied in this research were qualitative and quantitative method where the qualitative method used a structured interview to respondents, while the quantity method involved a questionnaire distribution to total 100 respondents (10 project owners, 45 implementer contractors, and 45 consultants). Based on the result of this study, factors causing delays in the completion of road improvement project in Jayapura Regency are: (1) labor factor with value of 3.5400, (2) equipment factor with value of 3.4400, (3) finance factor with value of 3.4200, (4) material factor with factor of 3.3900, (5) scope of work and contract/work documents with value of 3.3900, (6) site characteristic factor with value of 3.3700, (7) changes factor with value of 3.3400, (8) managerial factor with value of 3.3300, (9) situation factor with value of 3.3200, (10) planning and scheduling factor with value of 3.2900, and (11) inspection, control and work evaluation systems with value of 3.2700. As for the ranking of variables causing delays for the completion of road improvement project in Jayapura Regency are: (a) workforce discipline with value of 3.5600, (b) inadequate number of workers or in accordane with the existing work activities with value of 3.5600 and (c) workforce nationalism with value of 3.5300

ADHD in children and adolescents: Guideline-based online assessment in the consortium project INTEGRATE-ADHD.

The consortium project INTEGRATE-ADHD compared administrative data on the presence of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with the results of a parent survey and a comprehensive clinical assessment based on the S3 guideline of the Association of the Scientific Medical Societies in Germany (AWMF). Due to the COVID-19 pandemic, the clinical assessment was carried out online. The article describes how a guideline-based clinical assessment of ADHD can be implemented in an online setting. A specially developed diagnostic matrix is presented to illustrate the assessment procedures and the diagnostic decision-making process. The matrix is intended to help the diagnostician to gain an overview of the numerous individual findings that have been collected using different assessment perspectives and methods (e.g. diagnostic interviews, rating scales, performance tests) in order to make a well-founded and transparent diagnostic decision. The consortium project INTEGRATE-ADHD has shown that an online assessment can be implemented in a guideline-compliant manner and allows a valid clinical decision. The diagnostic strategy is discussed with reference to international guidelines and recommendations for online diagnostics (e.g. aspects of feasibility, acceptability and safety of the assessment procedures). The challenges and opportunities of using online assessments in clinical practice are also described.

A Risk Management Application by Failure Mode and Effect Analysis (FMEA) Method in A Road Drainage Channel Construction Project at H.M Ardan Street of South Sangatta District East Kutai, Indonesia

A construction project of road drainage channel in H.M Ardan Street, South Sangatta District (Multy Years) is included into type of construction project with high level of risk and work accidents since it has large number of workers, the use of sophisticated work tools and machines that require special methods and skills also strong supervision in its usage. These matters could bring undesirable impact potentiality in particular for the occupational safety and health aspect. A negligence of OSH implementation in the construction project can lead to work accident risk within the project. A work safety management is a part of management aspect with function to prevent any work accidents. Its prevention can be done by controlling the occurrence of high-potential work accidents whether in terms of consequences, occurrence probability, also simplicity in its detection. Many safety management methods have been introduced as method that able to be used for potential work accident identification, or measure the level of work accident’s risk, also for evaluating the work accidents; which leads to the Failure Mode and Effect Analysis (FMEA) method as the most appropriate method to achieve the objectives as described above. The selected method for this research was Failure Mode and Effect Analysis (FMEA) method, whereas the data source of this research were primary data obtained from interviews and questionnaires, and secondary data obtained from site plan drawings and identification data of the construction of drainage channels on H.M Ardan Street of South Sanggata District (Multi Years). According to FMEA analysis, there were 15 dominant risks with RPN values above the average value with 4 risks having a value of 48 as the highest RPN value found in this study. Type of risks with the highest RPN value were (a) stricken by heavy equipment and materials during loading and unloading construction materials; (b) fatigue due to an overly busy mobilization schedule; (c) workers fall while installing the formwork; (d) workers’ hand was pierced by nail or getting hit by hammer or wood. Furthermore, by the domino analysis conducted for this research, it produced several precautions and prevention recommendations that grouped into three main stages: Lack of Control, Basic Causes, and Immediate Causes.

Underexplored food safety hazards of beekeeping products: Key knowledge gaps and suggestions for future research.

These days, a growing consumer demand and scientific interest can be observed for nutraceuticals of natural origin, including apiculture products. Due to the growing emphasis on environmental protection, extensive research has been conducted on the pesticide and heavy metal contamination of bee products; however, less attention is devoted on other food safety aspects. In our review, scientific information on the less-researched food safety hazards of honey, bee bread, royal jelly, propolis, and beeswax are summarized. Bee products originating from certain plants may inherently contain phytotoxins, like pyrrolizidine alkaloids, tropane alkaloids, matrine alkaloids, grayanotoxins, gelsemium alkaloids, or tutin. Several case studies evidence that bee products can induce allergic responses to sensitive individuals, varying from mild to severe symptoms, including the potentially lethal anaphylaxis. Exposure to high temperature or long storage may lead to the formation of the potentially toxic 5-hydroxymethylfurfural. Persistent organic pollutants, radionuclides, and microplastics can potentially be transferred to bee products from contaminated environmental sources. And lastly, inappropriate beekeeping practices can lead to the contamination of beekeeping products with harmful microorganisms and mycotoxins. Our review demonstrates the necessity of applying good beekeeping practices in order to protect honeybees and consumers of their products. An important aim of our work is to identify key knowledge gaps regarding the food safety of apiculture products.

Proximate analysis of low-cost locally produced weaning foods and its safety aspects, in comparison to imported weaning foods

Proximate analysis of low-cost locally produced weaning foods and its safety aspects, in comparison to imported weaning foods

Methodology for estimating ethanol concentration with artificial intelligence in the presence of interfering gases and measurement delay

Gas concentration detection is a vital aspect of environmental monitoring, industrial safety, and various other applications. Metal Oxide (MOX) sensors have gained considerable attention in this context due to their low cost and ability to detect several gases, although their selectivity is a potential drawback. In this paper, a data-driven approach for the detection and estimation of ethanol concentration using MOX sensors in the presence of interfering gases is presented, with a dual emphasis on the impact of delay between gas transmission and sensor detection and the incorporation of heater current and voltage, alongside sensor current readings. A delay in sensor response can lead to erroneous readings and potentially compromise safety and environmental assessments. To tackle this issue, an incremental method for the identification of the delay length is proposed, and its effectiveness in improving the estimations of gas concentration is demonstrated by implementing three distinct regression techniques: Linear Regression (LR), Support Vector Regression (SVR), and Random Forest (RF). The analysis is then extended to incorporate the utilization of heater current and voltage, alongside sensor current readings. The experimental results demonstrate the effectiveness of the proposed method in handling measurement delay processing and its robustness to the presence of interfering gases.

Enhancing pilot vigilance assessment: The role of flight data and continuous performance test in detecting random attention loss in short IFR flights

Situational awareness (SA) and fatigue management are crucial aspects of aviation safety, particularly during demanding flight phases. This study introduces an innovative approach employing flight data, machine learning, and Continuous Performance Test (CPT) metrics to predict pilot performance and SA during instrument approaches under Instrument Meteorological Conditions (IMC). Data were collected from over 10 pilots across more than 40 flights in a high-fidelity Cessna 172 analog flight simulator.Significant correlations were observed between dynamic cognitive performance parameters and the exceedance shape factor, a novel measure of pilot sustained attention introduced in this research. Key variables identified through correlation analysis included variability, interstimulus change, and reaction time standard deviation.Importantly, commission scores and reaction time standard deviation emerged as key predictors in the machine learning model, specifically the Optimizable Gaussian Process Regression (GPR) model with a radial basis function kernel. The model achieved a validation R-squared of 0.90 and a test R-squared of 0.70. These systems could incorporate additional data sources, such as eye-tracking and scan pattern analysis, for a better assessment of pilot SA and fatigue levels. While post-flight measurements are inherently reactive, they are effective for monitoring the degradation of pilot CPT scores after each leg of high-frequency, short-duration flights.Notable limitations include the need to understand individual cognitive differences among pilots, such as age, experience, and cognitive style. The predictive model also requires validation in actual flight conditions to determine its ecological validity. Future research should aim to address these limitations, generalize the findings, and integrate CPT data with other sensor inputs to provide a more comprehensive understanding of pilot performance.

Hansen solubility parameters and quality-by-design oriented optimized cationic nanoemulsion for transdermal drug delivery of tolterodine tartrate

Tolterodine tartrate (TOT) is a selective anti-muscarinic drug to treat urinary urgency and overactive urinary bladder (OAB) occurring in children, renal disease and elderly patients. Oral delivery is associated with several adverse effects. We addressed HSPiP and QbD (quality by design)-oriented TOT loaded cationic nanoemulsions for transdermal delivery. Hansen solubility parameters (HSP) screened excipients based on theoretical solubility whereas, QbD optimized cationic nanoemulsions (CNE-TOT-6). Formulation characteristic parameters were desirable to execute targeted in vitro drug release and ex vivo permeation profiles. In vitro hemolysis was conducted at varied concentrations whereas, histopathological study supported the safety aspect of CNE-TOT6. A comparative bioavailability was carried out in a rat model. Capmul PG8 (CAP), tween 80, and PEG 400 (polyethylene glycol 400) were screened based on HSP and experimental solubility data. QbD suggested optimized content of CAP, tween 80, and PEG 400 to achieve the lowest value of size (184 nm), maximum % entrapment efficiency (87.2 %), high zeta potential (+32.6 mV), optimum viscosity (47.19 cP), and high extrudability (96 %) as compared to its gel. High gel consistency slowed down the drug release and permeation flux as compared to CNE-TOT6 suspension. Hemocompatible CNE-TOT6 increased pharmacokinetic parameters as compared to the control and gel without causing skin toxicity after application. Thus, HSPiP and QbD oriented cationic nanoemulsions are promising carriers to treat overactive urinary bladder.

Development of ROS-sensitive capofungin hydrogel by crosslinking chitosan with four-arm polyethylene glycol derivative for treatment of vulvovaginal candidiasis

Both exogenous and endogenous reactive oxygen species (ROS) in vulvovaginal candidiasis (VVC) play pivotal roles in promoting the hyphal formation of Candida albicans (CA), which suggests that clearing ROS could inhibit CA hyphae formation. A ROS-sensitive hydrogel (CAS@4Arm-PB/CS) was formulated by using a novel four-arm polyethylene glycol (4Arm-PEG) derivative (4Arm-PB) as a crosslinking agent, chitosan (CS) as the hydrogel matrix, and caspofungin (CAS) as the antifungal drug against CA. The ROS-sensitivity, disintegration mechanism, crosslinking action, swelling degree, microstructure, modulus, and rheological properties of 4Arm-PB were characterized. According to the results, 5.0 % 4Arm-PB could quickly and efficiently cross-link 0.5 mg/mL of CS. The ROS-sensitivity of 4Arm-PB was 10–50 μM, indicating a strong ROS sensitivity. The in vitro and in vivo anti-CA results indicated that CAS@4Arm-PB/CS not only cleared endogenous and exogenous ROS and inhibited the formation of CA hyphae and biofilm but also contributed beneficially to the treatment of VVC mice caused by CA infection, implying a certain safety aspect and an in vivo applicability. This research introduces a novel functional crosslinking agent for CS hydrogel formulation, presenting a new avenue for hydrogel-based drug delivery systems and therapeutic strategies for VVC treatment.

"Because I Am a Female": Stigma and Safety Perspectives from Racially/Ethnically Diverse Women with Serious Mental Illnesses.

Individuals with serious mental illnesses (SMIs) face safety risks related to their mental health conditions that are often compounded by experiences of trauma, victimization, residence in impoverished neighborhoods, and histories of homelessness. Stigma and safety challenges significantly impact community integration for individuals with SMIs, particularly women, who often bear a disproportionate burden of vulnerability, gender-based stigma, violence, and other inequalities. This study investigates how women with SMIs engage in the meaning-making of their safety and stigma experiences that, in turn, influence their community integration. From a large multi-site study exploring community experiences of racially/ethnically diverse participants with SMIs, a subsample of 28 cis and trans-gender women, who reported experiencing gendered stigma and a lack of safety, were chosen for the current study. The interviews were analyzed using modified principles of Interpretive Phenomenological Analysis (IPA) to understand how women with SMIs made meaning of their safety and stigma encounters in their families, communities, and neighborhoods. IPA analysis resulted in the emergence of themes within a broad category of safety that represented participants' meaning-making about their physical safety and stigma experiences. Specifically, we used the broad themes from an existing framework of safety called 'Navigating Safety' model as sensitizing concepts for our analysis. Physical and psychological aspects of safety for this study were experienced in tandem whereby the women made sense of how their experiences of a lack of physical safety in multiple contexts shaped their sense of self, internalized stigma, and their social relationships. Within the broad theme of physical safety, participants described unsafe neighborhoods, exposure to domestic and intimate partner violence, and vulnerability to sexual violence. Additionally, under psychological safety, we identified how gender-based norms, race and ethnicity, sources of stigma (internalized, familial, and societal), and social isolation contributed to their mental health and social relationships (particularly with family). These findings highlight how the compounding influence of the intersection of multiple stigmatized identities exerts safety challenges on the lives and community experiences of women with SMIs. Focusing on access and affordability of appropriate gender-responsive resources for women, including trauma-informed care, could reduce hospitalizations, mental health symptoms, and stigma so they can safely integrate into their communities.

Mechanism analysis and performance comparison of extractive distillation with different extractants for separating methyl tert-butyl ether/methanol mixture

Methyl tert-butyl ether (MTBE) is an important chemical raw material and fuel additive commonly used in the chemical industry and can form minimum boiling azeotrope with methanol (MeOH). In this article, extractive distillation processes with common-extractant (diethylene glycol, DG), counter-extractant (chlorobenzene, CB) and ionic liquid ([MIM][HSO4]) for the separation of MTBE and MeOH binary azeotrope are investigated simultaneously for the first time. Moreover, five quantum chemical calculation methods of σ-profiles, electrostatic potential, interaction energy, Hirshfeld surface and weak interaction are used simultaneously for the first time to reveal the extractive distillation mechanism of different extractants in detail. Finally, three extractive distillation processes (CED-IL, CED-DG, CED-CB) are established and optimized with total annual costs (TAC) and CO2 emissions as objectives. Their performances are comprehensively compared from the aspects of economy, environment, energy, exergy and inherent safety under the optimal conditions. The results demonstrate that, in comparison to the CED-DG process, the CED-IL process reduces TAC by 31.0%, total energy consumption (TEC) and gas emissions by 27.7%, process route index (PRI) by 36.4% and increase thermodynamic efficiency by 46.4%, while the CED-CB process increases TAC by 29.1%, TEC and gas emissions by 23.2%, PRI by 22.1% and reduce thermodynamic efficiency by 11.4%.

AN INTEGRATED ANALYSIS OF GREEN HIGHWAY ASSESSMENT CRITERIA FOR SUSTAINABLE INFRASTRUCTURE DEVELOPMENT

In line with the Sustainable Development Agenda 2030, all industries are slowly moving toward a greener approach through their activities and practices. The construction industry is a major contributor to overall economic growth as it provides infrastructure and physical facilities for people. However, the activities involved have caused several environmental impacts, such as pollution, climate change, destruction of natural habitats, landfill waste, and overconsumption of global resources. Therefore, this study presents a comprehensive analysis on the infrastructure work, which is the green highway assessment. The assessment criteria and rating methods were derived from seven prominent frameworks, including Greenroads, WISE, GreenLITES, I-LAST, BE2ST, Greenroads Manual, and MyGHI. Moreover, this research evaluates these sustainable criteria across five elements of green highway development: sustainable design and construction activity, energy efficiency, environmental and water management, materials and technology, and social and safety aspects. This research adopted a systematic literature review and comparative analysis to identify commonalities, differences, and gaps in existing assessment frameworks, providing insights into the holistic evaluation of green highways and sustainable infrastructure projects. The findings of this research contribute to advancing the understanding of green highway initiatives, especially in the local context, and policy development in the field of sustainable infrastructure.

Patient safety initiatives and practices in Nigerian healthcare settings: A comprehensive analysis of current knowledge, challenges, and barriers

The imperative of patient safety in healthcare takes a central stage, more so in the context of Nigeria. This review aims to provide a comprehensive understanding of the patient safety landscape in Nigeria, drawing on 12 empirical studies. This study aims to elucidate the multifarious challenges and barriers health-care professionals encounter in Nigeria concerning patient safety. Concurrently, it delves into the prevailing patient safety culture and the factors shaping it. This study used secondary data to conduct a systematic review of existing literature; 12 studies, spanning from 2015 to 2022, were meticulously examined. These explorations cover a broad spectrum of patient safety aspects in Nigeria, focusing particularly on the insights of nurses and doctors. Through the use of thematic analysis, the studies’ synthesis illuminates a significant gap between the envisioned safety protocols and their on-ground realization. Exacerbating this challenge is the acute lack of resources, which invariably hampers the quality of care. In addition, barriers to effective communication and inadequate reporting mechanisms emerge as significant obstacles. The deficiencies in consistent training and education are also prominent, which stand as potential vulnerabilities in the system. The palpable need for heightened awareness, emphasis on recurrent training initiatives, and strict adherence to established safety guidelines are amplifying these concerns. It was, thus, concluded that the healthcare trajectory in Nigeria, as informed by this review, underscores a pressing need for systemic interventions to elevate patient safety standards. Such a transformative journey demands the concerted efforts of all stakeholders, fostering an environment that prioritizes patient safety and enhances the overall trust in Nigeria’s healthcare system.

Workplace Hazard Identification through Near-Miss Reports: A Social Network Analysis

Occupational Safety and Health (OHS) is an effort to create a safe and healthy working environment. The company, which is engaged in power generation, experienced many near-miss cases from 2016 to 2023. Near-miss incidents are an early signal of the potential for severe accidents in the future if not resolved immediately. Identifying and addressing potential hazards early is necessary to prevent fatal work accidents. This study aims to analyze the reporting pattern of near-miss incidents by company employees through the IZAT application (Zero et al.) with a social network analysis (SNA) approach. This method identifies relationships and interaction patterns between employees in reporting near-miss incidents, thus revealing objects that need special attention. Data was obtained from September 2020 to July 2023. The analysis showed that 276 employees actively reported various near-miss incidents through IZAT (Zero Accident Assistant Application). This pattern reflects employees' sensitivity to potential hazards in their work environment. The findings of this study make a positive contribution to the improvement of the occupational safety and health management system in the company regarding the mitigation of potential hazards based on incoming report data. The recommendations provided are related to occupational safety aspects that need to be prioritized for management improvement. The implication of this research is to increase employee awareness in identifying and reporting potential hazards so as to prevent work accidents in the future.

In Vitro Safety Study on the Use of Cold Atmospheric Plasma in the Upper Respiratory Tract.

Cold atmospheric plasma (CAP) devices generate reactive oxygen and nitrogen species, have antimicrobial and antiviral properties, but also affect the molecular and cellular mechanisms of eukaryotic cells. The aim of this study is to investigate CAP treatment in the upper respiratory tract (URT) to reduce the incidence of ventilator-associated bacterial pneumonia (especially superinfections with multi-resistant pathogens) or viral infections (e.g., COVID-19). For this purpose, the surface-microdischarge-based plasma intensive care (PIC) device was developed by terraplasma medical GmbH. This study analyzes the safety aspects using in vitro assays and molecular characterization of human oral keratinocytes (hOK), human bronchial-tracheal epithelial cells (hBTE), and human lung fibroblasts (hLF). A 5 min CAP treatment with the PIC device at the "throat" and "subglottis" positions in the URT model did not show any significant differences from the untreated control (ctrl.) and the corresponding pressurized air (PA) treatment in terms of cell morphology, viability, apoptosis, DNA damage, and migration. However, pro-inflammatory cytokines (MCP-1, IL-6, and TNFα) were induced in hBTE and hOK cells and profibrotic molecules (collagen-I, FKBP10, and αSMA) in hLF at the mRNA level. The use of CAP in the oropharynx may make an important contribution to the recovery of intensive care patients. The results indicate that a 5 min CAP treatment in the URT with the PIC device does not cause any cell damage. The extent to which immune cell activation is induced and whether it has long-term effects on the organism need to be carefully examined in follow-up studies in vivo.

MiniMed 780G System Use in Type 1 Diabetes During Ramadan Intermittent Fasting: A Systematic Literature Review and Expert Recommendations.

This article offers a systematic literature review (SLR) on the use of the MiniMed 780G automated insulin delivery system (MM780G) in people with type 1 diabetes (PwT1D) during Ramadan intermittent fasting. It also presents consensus recommendations on the use of MM780G during the Ramadan period. The SLR was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology. The recommendations resulted from a consensus-forming process involving a panel of experts. The process considered evidence found in the SLR as well as the expert opinions. In total, six studies were included in the SLR. The evidence and expert opinions led to recommendations related to (a) pre-Ramadan counseling of MM780G users who plan to fast; (b) suggested MM780G settings, meal announcement strategy, and safety aspects during Ramadan (including a contingency plan); and (c) post-Ramadan transition into and out of Eid-al-Fitr festivities. The SLR findings showed that the MM780G maintains glycemic control at target in PwT1D during Ramadan (meeting continuous glucose monitoring-based clinical targets proposed by the International Consensus on Time-in-Range) while ensuring low rates of hypoglycemia and diabetic ketoacidosis. Automated insulin delivery also helps PwT1D fast more days of Ramadan compared with users of other less advanced modalities of treatment. Pre-Ramadan guidance on specific aspects of the MM780G along with the International Diabetes Federation and Diabetes and Ramadan International Alliance counseling guidelines is recommended. There is still a challenge with post-Iftar hyperglycemia, which could potentially be mitigated by following the recommendations outlined in this article.

Investigation of scaling-down experiments for accidental CO2 leakage dispersion risks in constant-pressure transportation pipelines within the CCUS process

Within the framework of strategies to prevent global warming, the safety of CO2 transportation pipelines requires thorough hazard analysis. Accidental leakage during long-distance CO2 transport, influenced by the size of the leakage opening, typically occurs under constant pressure conditions in the CCUS process. This paper introduces an innovative scaled experimental apparatus with an elliptical orifice, designed to simulate leakage due to free rupture in pipelines. The goal is to understand the risk characteristics of constant-pressure leakage in transportation pipelines. The results indicate that during leakage, the pressure drop in the source CO2 pipeline is less than 0.3013 MPa/s, which can be considered constant pressure leakage. The Mach disk size dm has a linear relationship with the elliptical leakage orifice ab. The scaled experiments also show that temperatures can drop to as low as −78°C, indicating significant low-temperature risks. This scaling experiment provides a new approach for predicting and mitigating diffusion risks in long-distance pipeline transportation by examining the relationship between pipeline length and orifice diameter. The research data and results contribute to a deeper understanding of the safety aspects of long-distance transportation of CO2 under constant pressure leakage conditions, providing a basis for risk assessment of leakage accidents and environmental protection measures.

Intravenous injection of allogenic canine mesenchymal stem cells in 40 client-owned dogs: a safety assessment in veterinary clinical trials

BackgroundThe aim of this study was to evaluate the adverse effects of allogeneic mesenchymal stem cells (MSCs) transplanted via intravenous infusion in dogs and examine their safety. We performed a retrospective analysis of various clinical assessments, including physical examination, blood tests, and radiographs, and monitored the formation of neoplasms during a 6-month follow-up period in 40 client-owned dogs that received intravenous infusion of adipose tissue-derived MSCs (AT-MSCs) for the treatment of various underlying diseases between 2012 and 2018.ResultsNo significant adverse effects of MSC therapy were detected by clinical assessment, blood tests, or radiographic examination in the 6-month follow-up period after the first MSC treatment. Additionally no new neoplasms were observed during this period.ConclusionsTo our knowledge, this study is the first to evaluate the safety aspects (≥ 6 months) associated with intravenous allogeneic AT-MSC infusion. These results suggest that allogenic AT-MSC infusion could be a useful and relatively safe therapeutic approach in canines.

Developmental approach of safety in ergonomics/human factors: insights of constructed safety in six work environments

This article brings together works on the concept of constructed safety in ergonomics, carried out over the last twenty-five years. Firstly, we situate this approach to safety in relation to previously developed existing models (e.g. regulated and managed safety) with regard to the development of activity-centred ergonomics. We then present six research actions in activity-centred ergonomics from a selection of different fields, from small companies to the industry of the future in an international group: public works, hospitals, aeronautical industry, railway transport, agriculture, and chemical industry, in order to describe constructed safety applications. The results highlight that constructed safety is respectively raised by mutual knowledge between workers and management, collective decision making, collective reflexive work on safety rules, spatiotemporal articulation of the different safety sources, knowledge integration on pesticide exposure situations by designers and regulation, social regulation sustaining risk understanding and safety aspect involving a diversity of actors (workers, preventionists, managers, local residents and public authorities). By focusing on the analysis of actual safety practices in real work and real exposure situations, constructed safety aims to account for the way in which safety is deployed on a daily basis to meet production and health objectives. This understanding contributes to the design of safe work systems in a developmental way and to propose an operating model of constructed safety.