ABSTRACT Virtual Reality (VR) simulation training can offer social work students a person-centered learning approach that emphasizes in-vivo experience in applying social work skills to a case simulation, with post-simulation debriefing that links students’ experiences back to direct practice learning objectives. VR simulation offers the unique opportunity for interprofessional group decision-making and support in providing care, offering a context where immediate feedback around decision-making is encouraged along with the space to consider alternative decisions. This inaugural VR simulation experience for social work students in our College of Public Health (CPH) centered on an interprofessional case situated in a host setting (hospital clinic). The VR training simulation offered a safe learning environment, encouraging student dyad teams to manage engagement and adjust their skills in real-time in a low-stakes scenario. Students saw value in the learning space and were interested in participating in other case scenarios. The early adoption of VR in the CPH enabled the Department of Social Work to lead the way for interprofessional custom case creation for working with substance-involved clients in collaboration with a Certified Healthcare Simulation Educator to deliver simulations that meet Healthcare Standards of Best Practice.