Saccharothrix Sp Research Articles

The total synthesis of the natural product endothelin converting enzyme (ECE) inhibitor, WS75624 B

The first total synthesis of WS75624 B, 1, an endothelin converting enzyme inhibitor produced in a fermentation broth of Saccharothrix sp. No. 75624 is reported herein. WS75624 B is synthesized in 14 steps from commercially available kojic acid, 2. The synthetic methodology allows for facile substitution at multiple sites on the molecule.

Formamicin, a novel antifungal antibiotic produced by a strain of Saccharothrix sp. I. Taxonomy, production, isolation and biological properties.

Formamicin, an antifungal antibiotic, was isolated from the cultured broth of an actinomycete strain. The strain was isolated from a soil collected at Setagaya-ku, Tokyo, Japan, and identified as Saccharothrix sp. MK27-91F2. Formamicin was extracted with acetone from cultured mycelia and purified by silicagel and Sephadex LH-20 column chromatographies and CPC (Centrifugal liquid-liquid Partition Chromatography). Formamicin showed strong antimicrobial activity against phytopathogenic fungi.

Formamicin, a novel antifungal antibiotic produced by a strain of Saccharothrix sp. II. Structure elucidation of formamicin.

A novel antifungal antibiotic, formamicin, was isolated from the culture broth of Saccharothrix sp. MK27-91F2. The absolute structure of formamicin was determinated by spectroscopic and X-ray crystallographic analysis and degradation study.

Phosphonothrixin, a novel herbicidal antibiotic produced by Saccharothrix sp. ST-888. I. Taxonomy, fermentation, isolation and biological properties.

A novel herbicidal compound, phosphonothrixin, was found in the fermentation broth of Saccharothrix sp. ST-888 cultured on a vegetable juice medium. The compound exhibiting acidic and hydrophilic properties was obtained when the fermentation broth of ST-888 was subjected to ion exchange chromatography, gel filtration chromatography and ion-pair chromatography. Phosphonothrixin significantly inhibited germination of gramineous and broadleaf weeds. Foliar application of this antibiotic gave rise to chlorosis in all of the plants tested.

Total synthesis of (+/-)-phosphonothrixin, a novel herbicidal antibiotic containing C-P bond.

Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. ST-888, with a unique structure possessing a C-P bond and an isoprene unit. The total synthesis of this antibiotic was accomplished from methyl (bromomethyl)acrylate in six steps.

Phosphonothrixin, a novel herbicidal antibiotic produced by Saccharothrix sp. ST-888. II. Structure determination.

Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. ST-888. This unique compound possessing a C-P bond and an isoprene unit was determined to be 2-hydroxy-2-hydroxymethyl-3-oxobutyl-phosphonic acid. Unusually rapid proton-deuterium (H-D) exchange of the methyl ketone unit of this antibiotic in D2O solution was observed. Phosphonothrixin can be classified as a new type of natural product herbicide having a C-P bond in the molecule.

Galacardins A and B, new glycopeptide antibiotics.

A strain of actinomycetes identified as Saccharothrix sp. SANK 64289 was found to produce new antibiotics, galacardins A and B. Their physico-chemical properties showed that they were new members of glycopeptide antibiotics. They were structurally related to beta-avoparcin but differed from it only in sugar composition. Though beta-avoparcin does not contain galactose, galacardins A and B did contain two and one moles of galactose, respectively. They showed strong antimicrobial activity against Gram-positive bacteria and also showed excellent in vivo protective activity against Staphylococcus aureus infection in mice.