S1 Type Research Articles

Treatment outcomes and esophageal cancer incidence by disease type in achalasia patients undergoing peroral endoscopic myotomy: Retrospective study.

This retrospective study aimed to compare treatment outcomes and postoperative courses, including the incidence of esophageal cancer (EC), according to disease types, in 450 achalasia patients who underwent peroral endoscopic myotomy (POEM). Data from consecutive POEM procedures performed from September 2011 to January 2023 at a single institution were reviewed. Achalasia was classified into straight (St), sigmoid (S1), and advanced sigmoid (S2) types using esophagography findings. Regarding efficacy, POEM was considered successful if the Eckardt score was ≤3. A statistical examination of the incidence and trend of EC occurrence across the disease type of achalasia was conducted using propensity score matching. Of the 450 patients, 349 were diagnosed with St, 80 with S1, and 21 with S2. POEM efficacy was 97.9% at 1 year and 94.2% at 2 years postprocedure, with no statistical difference between disease types. Using propensity score matching, the incidence of EC in each disease type was as follows: St, 1% (1/98); S1, 2.5% (2/77); S2, 10% (2/18). While no statistical significance was observed between St (1.0%: 1/98) and all sigmoid types (4.0%, 4/95; P = 0.3686). However, a trend test revealed a tendency for EC to occur more frequently in the order of S2, S1, and St type with a statistically significant difference (P = 0.0413). Outcomes of POEM are favorable for all disease types. After POEM, it is important not only to monitor the improvement of achalasia symptoms but also to pay attention to the occurrence of EC, especially in patients with sigmoid-type achalasia.

Investigation of Metronidazole Resistance-Associated Mutations and Virulence Genotypes of Helicobacter pylori Isolated from Egyptian Population: A Cross-Sectional Study

IntroductionThis cross-sectional study assesses the prevalence of metronidazole resistance-associated mutations and virulence genotypes in Helicobacter pylori (H. pylori) strains isolated from the Egyptian population. H. pylori infection is a significant public health concern, with antibiotic resistance challenging its eradication. MethodsGastric biopsy samples were collected from symptomatic patients referred for upper gastrointestinal endoscopy at selected healthcare facilities. The study included 250 participants with symptoms suggestive of H. pylori infection and aged 18 years or older. Biopsy samples were obtained using standard endoscopic techniques, and H. pylori strains were isolated and identified in the laboratory. Antimicrobial susceptibility testing was conducted using standard methods. Molecular analysis, including polymerase chain reaction (PCR) and sequencing, was performed to identify metronidazole resistance-associated mutations (rdxA and frxA) and virulence genotypes (cagA and vacA). ResultsAntimicrobial susceptibility testing revealed that 43.6% of the isolates were resistant to metronidazole, while 11.8%, 4.5%, and 55.4% were resistant to clarithromycin, amoxicillin, and levofloxacin. Molecular analysis identified rdxA and frxA mutations in 36.3% and 31.8% of the isolates, respectively, indicating metronidazole resistance-associated mutations. Additionally, 60.0% of the isolates were positive for the cagA gene, and 80.0% had the vacA s1 type, both associated with increased virulence. A significant association was found between metronidazole resistance and the presence of cagA gene, vacA s1 type, rdxA mutation, and frxA mutation. Statistical analysis revealed associations between specific mutations and virulence genotypes with respective odds ratios, indicating higher likelihoods of metronidazole resistance in isolates exhibiting these genetic characteristics. ConclusionsThis study highlights the prevalence of metronidazole resistance and the association between specific mutations and virulence genotypes in H. pylori strains isolated from the Egyptian population. The findings underscore the importance of monitoring antibiotic resistance patterns and understanding the genetic determinants of virulence in H. pylori for effective management and treatment strategies.

Assessment of groundwater quality and suitability for irrigation purpose using irrigation indices, remote sensing and GIS approach

Assessing both the quantitative and qualitative aspects of groundwater is essential for evaluating its suitability for irrigation and drinking purpose. Consequently, this current study showcases its importance by determining groundwater quality in Sundargarh district of, India, where groundwater serves as vital water resources. 360 groundwater samples were collected from various dug wells during pre-monsoon season of 2014–21 and analyzed for major ions, some important irrigation water quality indices along with pH, EC and TDS. Statistical evaluation of groundwater quality parameters was performed by physiochemical analysis with association of ArcGIS 10.4 for developing the spatial mapping. Furthermore, statistical and hydrochemical analysis was executed by exhibiting box plot generation, correlation study and hierarchical cluster analysis followed by categorization of water facies in , 1920; CGWB, 2013; Gad and Hattab, 2019’ has/have not been found in the reference list. Please add the corresponding reference(s) to the reference list.>Xlstat 2023, SPSS 23 and Diagrammes 6.1. Groundwater is mostly characterized as Na+-SO42- and deep meteoric percolation (DMP) type based on Base Exchange Indices with the dominance of Ca2+ and HCO3− as the major cation and anion respectively. Besides that, groundwater from 92%, 96%, 84%, 100%, 99%, 98%, 57%, 64%, 100%, 77%, 98% and 89% dug wells are found to be highly suitable for cultivation of major crops of this district depending on spatial variation of EC, TDS. Cl−, SAR, RSC, KR, PI, %Na, ESP, MAR, SSP and PS respectively. Groundwater facies are mostly categorized as Ca–HCO3 (60.8%) and C2–S1 (65.5%) type based on Piper and Wilcox diagram respectively. The dominant geochemical controlling factors are evaporation, reverse ion exchange and silicate weathering. Therefore, the objectives of this present research may provide necessary information to the regulatory boards and policy makers for efficient monitoring of groundwater quality and contaminated aquifers in Sundargarh district to make fit this crucial water resources for agricultural purpose.

The N270 as an index of consumer commodity color preference in the S1-S2 paradigm.

Affective decision-making is a prominent topic in consumer psychology research, with its core assumption being that consumers tend to purchase brands and commodities they like. However, the reasons behind why we develop emotional responses of liking or disliking toward certain commodities, as well as what the underlying neural mechanisms are, remain largely unknown. This study utilized the S1-S2 paradigm in an experiment wherein S1 presented 12 types of commodities and S2 displayed 48 distinct colored squares. Participants were instructed to assess whether they "Like" or "Dislike" the commodity in S1, which was colored with the S2 color. Electroencephalogram (EEG) recordings were obtained during the reaction process and subsequently analyzed to examine the components of S2-induced event-related potentials (ERPs). The analysis revealed that S2 elicited a significant N270 in the prefrontal scalp area under both the "Like" and "Dislike" conditions. Interestingly, the amplitude of the N270 was significantly higher during the "Dislike" condition compared to the "Like" condition. The N270 component was shown to reflect the conflict in physical attributes between S1 and S2, as well as the conflict between commodity and color. This highlights the potential utility of this component as an objective EEG indicator of consumer commodity color preferences in future marketing research.

PYOCIN S5 ACTIVITY AGAINST PSEUDOMONAS SYRINGAE PHYTOPATHOGENIC STRAINS

Pseudomonas syringae is the most frequently isolated bacterial plant pathogens. Previously we revealed a number of Pseudomonas aeruginosa strains – producers of bacteriocins (pyocins) with high activity against P. syringae. However, it was unknown, which type of pyocins possesses the activity against P. syringae strains. S5 and S1 pyocin genes were observed in the genome of most active strain–producer P. aeruginosa UCM В-333. Pyocins were induced by nalidixic acid (100 μg/ml). Using DEAE-cellulose chromatography we isolated two bacteriocin groups from initial lysate. Substances from the 10th fraction had nuclease activity (pyocin S1) and the 27th fraction - pore-forming activity (pyocin S5). It was revealed that S1 pyocin didn’t lead to growth inhibition of studied bacterial plant pathogens. However pyocin S5 caused appearance of growth inhibition area with diameter 14-20 mm. So, pyocins of S1 and S5 types are active substances in P. aeruginosa UCM В-333 lysates, but only S5 pyocin possess activity against P. syringae strains. fpt A receptor gene was revealed in genomes of all analyzed cultures, including used phytopathogenic strains. This fact can explain wide spectrum of pyocin S5 activity. It is suggested that pyocin S5 can be a potential biocontrol agent against phytopathogenic P. syringae strains.

Impact of long-term thermal exposure on the microstructure and creep resistance of (TiB+TiC+Y2O3)/α-Ti composite

In this study, the influences of thermal exposure on the microstructure and creep resistance of matrix alloy and (TiB+TiC+Y2O3)/α-Ti composites were systematically studied. The results indicate that long-term thermal exposure leads to β-Ti dissolution, as well as the precipitation of a large number of S1 type silicides and α2 particles. The high temperature and internal stress by thermal exposure promote β-Ti→α-Ti phase transition. In order to reduce the total energy, nanoscale {101̅1} transformation twins were formed at the α/β interfaces. The introduction of precipitates and nano twins leads to a significant improvement in the creep resistance after thermal exposure. The creep life can be increased by up to 108 %, while the steady-state creep rate can be reduced by an order of magnitude. After creep, there was no significant increase in the size of precipitated silicides and α2 particles. The rod-shaped S1 type silicide has a better pinning strengthening effect on dislocations than spherical S2 type silicide. Nano twins improve the stability of the α/β interfaces during creep. Some twins were coarsened after creep by merging mechanism. Twins and reinforcements provide nucleation sites for sub-grains during the creep process.

Visual Corticotectal Neurons in Awake Rabbits: Receptive Fields and Driving Monosynaptic Thalamocortical Inputs.

The superior colliculus receives powerful synaptic inputs from corticotectal neurons in the visual cortex. The function of these corticotectal neurons remains largely unknown due to a limited understanding of their response properties and connectivity. Here, we use antidromic methods to identify corticotectal neurons in awake male and female rabbits, and measure their axonal conduction times, thalamic inputs and receptive field properties. All corticotectal neurons responded to sinusoidal drifting gratings with a nonlinear (nonsinusoidal) increase in mean firing rate but showed pronounced differences in their ON-OFF receptive field structures that we classified into three groups, Cx, S2, and S1. Cx receptive fields had highly overlapping ON and OFF subfields as classical complex cells, S2 had largely separated ON and OFF subfields as classical simple cells, and S1 had a single ON or OFF subfield. Thus, all corticotectal neurons are homogeneous in their nonlinear spatial summation but very heterogeneous in their spatial integration of ON and OFF inputs. The Cx type had the fastest conducting axons, the highest spontaneous activity, and the strongest and fastest visual responses. The S2 type had the highest orientation selectivity, and the S1 type had the slowest conducting axons. Moreover, our cross-correlation analyses found that a subpopulation of corticotectal neurons with very fast conducting axons and high spontaneous firing rates (largely "Cx" type) receives monosynaptic input from retinotopically aligned thalamic neurons. This previously unrecognized fast-conducting thalamic-mediated corticotectal pathway may provide specialized information to superior colliculus and prime recipient neurons for subsequent corticotectal or retinal synaptic input.

Simulation of the casting and solidification process of the brake shoes intended for rolling stock

The paper presents the results obtained from the simulation of the casting and solidification process of the phosphorous cast iron brake blocks intended for rolling stock. The simulation of the casting and solidification process was carried out using the SolidWorks and Altair inspire cast programs. A S1 type brake shoe was chosen for this process. The solidification of phosphorous cast iron brake blocks is influenced by a number of constructive and technological factors. The simulation allows analysis of technological characteristics of casting and solidification of the alloy. The solidification process influences the micro and macrostructure of the parts, their compactness, mechanical strength, dimensional accuracy and surface quality.

Electron microscopic investigation of precipitation hardening in Al-Si based alloys

The present work was performed on Al-8.5%Si-1.75%Cu-0.55%Mg-0.2%Ti-0.32%Zr-0.015%Sr alloy (coded as 354 alloy) following T6 (at 160 °C) and T7 (at 240 °C) artificial aging conditions using high resolution transmission electron microscopy (HR-TEM). The main results inferred from the present study are the precipitation of GP zones in samples aged for 20 h at 160 °C along with S-Al2CuMg phase particles. Aging at 240 °C was carried out for different times, ranging between 30 min and 200 h. The quenched structures revealed a series of precipitations mainly GP zones at low aging times to Θ’-Al2Cu after 200 h together with the S-phase. No coherency was observed between the S-phase and the aluminum (Al) matrix. The growth of the S- phase takes place by precipitation of S2 type phase on the advancing S1-type phase. Mismatching was clearly observed at particle/matrix interfaces. High magnification images indicated the dissolution of some of the Θ” and Θ’ particles to enrich the nearby particles (coarsening). The start of incoherency is observed when the alloy is aged at 240 °C for 200 h.

Pemberian Scaffolding Kepada Siswa SMP dalam Menyelesaikan Soal Pisa Konten Change and Relationship

Change and relationship is a content in PISA that is classified as having a low score, because students experience errors in completing it, so to find out the student's mistakes, Newman's analysis is needed which is useful to find out the mistakes made by students, as well as scaffolding efforts to minimize and overcome errors. This study aims to describe the provision of scaffolding to junior high school students in solving PISA content change and relationship problems at Proklamasi Balongbendo Junior High School for the 2022/2023 even semester in April. Of the three classes consisting of classes VIII-a (32 students), VIII - B (31 students), and VIII-C (32 students). Then selected Class VIII-B purposively in this study, consisting of 16 male students and 15 female students. Purposive selection based on, special characteristics in the form of student ability and student activity in the classroom. The tests were conducted on all students of Class VIII - B, namely the initial ability test (TKA) and the PISA Ability Test (TKP). The subjects were selected based on the results of analysis of student answers and scores of initial ability test (TKA) and PISA ability test (TKP) and considering the UAS scores in mathematics subjects of students in semester 1, the subjects consisted of high ability subjects (S1), medium ability subjects (S2), and low research subjects (S3). The results of the study stated S1 able to read the question correctly, can understand the purpose of the problem, explain all the information in the question and be able to understand what is being asked, able to write a plan of completion, by doing pemisalan and using formulas that are in accordance with the solution of the question, mention the conclusions in accordance with the conclusions of the answers obtained from the work done. S2 is able to be able to read the problem correctly, explain what information is obtained from the problem, able to understand what is meant by the problem and write what is known and asked in the problem, able to transform the problem into a mathematical model by making a calculation from the information obtained in the problem, but have difficulty in performing calculation operations so as not to get the correct final result, S2 is able to write conclusions in accordance with the results obtained, but not precisely because the answers obtained are also not precise so that the results obtained in the conclusion are not correct. S3 is able to read the problem correctly, explaining all the information known from the question correctly. S3 does not define formulas and models math. S3 directly perform the overall calculation operation based on the information in the problem. And in the course of the interview the subject said with confidence that there was a proper formula to solve it, but he did not know the formula so did not write it down. S3 is not able to write the final conclusion precisely because the results of the answers obtained are also not appropriate. The type of error S1 in solving the PISA content change and relationship problem is a transformation error, and a process skill error. The types of S2 errors in solving PISA content change and relationship problems are Transformation errors, and process skill errors, and final answer writing (encoding). The types of S3 errors in solving PISA content change and relationship problems are comprehension errors, transformation errors, process skill errors, and final answer writing (encoding). Based on the type of error S1 is transformation, scaffolding given is reviewing, and restructuring. And the type of process skill error, scaffolding given is reviewing, restructuring, explaining. Based on the type of error made by S2 in solving the PISA content change and relationship Problem, the scaffolding transformation error given is reviewing, and restructuring, restructuring. The type of process skill error, scaffolding given is reviewing, and restructuring. Error encoding, scaffolding given is restructuring, and reviewing, restructuring. Based on the type of errors made by S3 in solving the PISA content change and relationship problem, namely understanding errors, scaffolding given is reviewing and process skill errors, scaffolding given is reviewing, developing conceptual reviewing explaining, restructuring. Error encoding scaffolding given reviewing, restructuring, reviewing.

Pengaruh Atribut Produk, Citra Merek, Harga Terhadap Keputusan Pembelian Sepeda Polygon Dalam Masa Pandemi Covid-19

Pandemic Covid-19 is an outbreak that creates new habits for people who start implementing health protocols starting from activities that also have a positive influence on the body. Cycling is one of the activities carried out by the community in their activities and spare time. Various bicycle brands are present in Indonesia, such as the Polygon Strattos S2, which is able to become a consumer choice in bicycle purchasing decisions. This study discusses the Influence of Product Attributes, Brand Image and Price on Polygon Bike Purchase Decisions during the Covid-19 Pandemic which focuses on the Strattos S2 type of bicycle which is a road bike. This research certainly has research respondents, namely the SCC (Strattos Cycling Club) bike community, totaling 45 respondents. The research technique used is non-probability sampling using questionnaires distributed to respondents. The data that has been obtained is processed using Staticial Product and Service Solution (SPSS) Software. After that, analysis was carried out using IBM SPSS Statistics 16. The results obtained showed that Product Attribute Variable (1) had a significant and positive effect on the Purchase Decision variable, Brand Image Variable (2) obtained significant and positive results on the Purchase Decision variable, Price Variable ( 3) shows that there is a significant and positive effect on the Purchase Decision variable.

New Fractional Integral Inequalities Pertaining to Center-Radius (cr)-Ordered Convex Functions

In this work, we use the idea of interval-valued convex functions of Center-Radius (cr)-order to give fractional versions of Hermite–Hadamard inequality. The results are supported by some numerical estimations and graphical representations considering some suitable examples. The results are novel in the context of cr-convex interval-valued functions and deal with differintegrals of the p+s2 type. We believe this will be an important contribution to spurring additional research.

Study on the Amalgamation of Jute Fabric and Leather for Lifestyle Applications

ABSTRACT During the process of tanning, huge quantities of wastes are generated posing major environmental risk if not managed effectively. Therefore, sustainability has become a great challenge for the industry. To overcome the challenge, an attempt has been made to develop lifestyle products using a combination of jute fabrics and leather. For the study, three different types of jute fabrics S1, S2, and S3 of varying compositions were sourced and examined for physical, structural, and thermal properties. It has been observed that most of the physical properties like breaking strength, breaking elongation, seam strength, abrasion resistance, light fastness of S2 and S3 fabrics are comparable or even better than goat nappa leather while the performance of S1 was not appreciable. In addition, performance of S3 fabric is better over other fabrics in water absorption. It was evidenced from analysis that S2 and S3 fabrics which are blends of jute and cotton performed well compared to 100% jute fabric S1. Consequently, combination products were developed and these products will certainly be a major breakthrough during a time when country is facing huge pollution crisis.

Functionalization of the PLLA surface with a femtosecond laser: Tailored substrate properties for cellular response

In this paper we present the possibilities of using a femtosecond fiber laser (τ = 260 fs, λ = 1030 nm) to modify a PLLA surface. Three types of developed structures S1, S2, S3 differed significantly in topography and surface morphology. Thanks to the use of pulse overlapping in both scanning directions, the structures S1 and S2 were highly homogeneous, while in structure S3 the parallel grooves were obtained by pulse overlapping in one direction. The modified surfaces were examined for morphology (scanning electron microscopy), roughness (optical profilometry), wettability (measurement of the contact angle) and changes in the chemical structure of the polymer (infrared spectroscopy, gel permeation chromatography). The possibility of modifying these surface properties in a broad range was also discussed. The conducted cellular studies showed that there was no cytotoxicity with regard to all samples and that the pace of fibroblast colonization of samples S1 was higher compared to that of the control during the first 24 h of experiment. Moreover, the ability of S. aureus (pathogenic bacteria) and of a biotechnologically useful fungus Saccharomyces boulardii to colonize the manufactured structures was also assessed. In this case, no significant differences in the number of biofilm-forming cells were observed between the analyzed samples and the control setting. Obtained results indicate that applicability of such surface modifications should be further investigated, especially for the development of bone implants and these biotechnological processes in which microbes are used to produce the desired yield of product.

KEBERHASILAN DUA JENIS STERILAN DAN LAMA PENYINARAN LAMPU UV (ULTRA VIOLET) PADA STERILISASI EKSPLAN BONGGOL PISANG TALAS (Musa paradisiaca L. var. sapientum)

The technique of cultivating talas bananas through tissue culture with corm explants can produce a large number of seedlings with uniform height and in a short time compared to conventional methods. However, it has a higher level of contamination, so it uses HgCl2 as the sterilant which is classified as hazardous and toxic (B3) chemical. The use of UV light exposure which is able to nonactivate contaminants can be recommended to replace the B3 material. The purposes of this study were to investigate the difference between the control and the UV light exposure time nested in sterilant types on the success of sterilization of talas banana (Musa paradisiaca L.var. Sapientum) corm explant; and to investigate the effects of sterilant types on the success of sterilization of talas banana (Musa paradisiaca L.var. Sapientum) corm explant. This study is an experimental study arranged in a Nested Completely Randomized Design with separate control repeated 3 times. The UV light exposure time (t1 = 1.0 hours; t2 = 1.5 hours; t3 = 2.0 hours; t4 = 2.5 hours and t5 = 3.0 hours) was nested in a type of sterilant (s1 = UV light; s2 = 0.2% Fungicide + 0.2% Bactericide + 70% Alcohol + 30% Bayclin + 20% Bayclin + Betadine + UV light). The results of the study show that the sterilization of talas banana corm explants (s1 type), without using B3 HgCl2 and only using UV light, can be recommended to be applied in the propagation of talas bananas through in vitro culture.

Weak Zinc-Zinc slipped triple bond in Zn2Li6 cluster

Weak Zn-Zn triple bond is achieved through six s1 type donors in the form of six Li atoms incorporated to Zn2 dimer which results in the formation of Zn2Li6 cluster. The proposed cluster is found to be global minimum in the potential energy surface. Accumulation of significant electron density in 4p orbitals of Zn has facilitated this bonding scenario. Various bonding analyses reveal the presence of triple bonding character and was found to be weak and slipped type. Out of the three bonds one is a conventional π bond while the other two are slipped bonds out of which one is of π type and the rest one is of σ type. The calculated thermodynamics of formation is also very favorable. The effective bond order (EBO) is calculated to be around 2.8 which also back the triple bonding nature.

Lymphaticovenular Anastomosis in Breast Cancer Treatment-Related Lymphedema: A Short-Term Clinicopathological Analysis from Indonesia.

Locally advanced breast cancer is commonly found in Indonesia. In this group of patients, aggressive treatment such as axillary lymph nodes dissection (ALND) with or without regional nodal irradiation (RNI) will increase the risk of breast cancer treatment-related lymphedema (BCRL) in our patients. Lymphaticovenular anastomosis (LVA) has been established as a minimally invasive approach in lymphedema surgery. In this study, we report our first experience of LVAs in BCRL patients. This was a cross-sectional study taken from breast cancer patients receiving ALND with or without RNI. From December 2018 until June 2020, we collected and described general patient information, tumor characteristics, diagnostic methods, and the outcome of LVA. Postoperative subjective symptoms scores (lymphedema quality-of-life score [LeQOLiS]) and lymphedematous volume (upper extremity lymphedema [UEL] index) were compared with preoperative ones. Seventy patients experienced BCRL with the mean age of 54.8 (9.4) years and mean body mass index of 28.1 (4.5). ALND was performed in 66 (97.1%) cases and RNI was given in 58 (82.9%) patients. Thirty-one (44.3%) patients were in the International Society of Lymphology stage 1, 24 (34.3%) in stage 2A, and 15 (21.4%) in stage 2B. The mean lymphatic vessel diameter was 0.5 (0.26) mm and 0.80 (0.54) mm for the vein. Lymphosclerosis severity was 7 (4%) in S0 type, 129 (74.1%) in S1 type, 37 (21.3%) in S2 type, and 1 (0.6%) in S3 type. In histopathology examination, S1 types were in lower grade injury, while S2 and S3 types were in the higher grade. Seven (53.8%) cases of S2 type showed severe fibrosis from trichrome staining. Postoperative LeQOLiSs were significantly lower than preoperative ones (5.6 ± 2.4 vs. 3.7 ± 2.6; p = 0.000). With the mean follow-up of 7.4 (3.7) months, the overall UEL index reduction was 9.2%; mean -11 (16.8). Postoperative UEL index was significantly lower than preoperative ones (117.7 ± 26.5 vs. 106.9 ± 18.5; p = 0.000). No complications were observed during this period. LVA reduced the subjective symptoms and UEL index in BCRL cases. Future studies using updated imaging technologies of the lymphatic system and longer follow-up time are needed to confirm our results.

Analisis Faktor-Faktor Yang Membedakan Persepsi Mahasiswa Tentang Corporate Social Responsibility (Studi Empiris pada Universitas Diponegoro)

Penelitian ini bertujuan untuk menguji faktor-faktor yang membedakan persepsi mahasiswa tentang Corporate Social Responsibility (CSR). Dalam penelitian ini, pengukuran hasil uji terhadap persepsi dilakukan pada tiap variabel yang terdiri dari jenis kelamin, asal-usul daerah, dan jenjang pendidikan, dengan dua jenis sampel yang berbeda. Penelitian ini dilakukan dengan metode survey dengan kuesioner terhadap dua jenis sampel yang berbeda, yaitu mahasiswa S1 dan mahasiswa S2. Kuesioner yang dibagikan terdiri dari 19 item pertanyaan. Dari hasil uji analisis dalam penelitian ini dapat dibuktikan bahwa pada variabel jenjang pendidikan terdapat perbedaan persepsi mahasiswa tentang Corporate Social Responsibility, sedangkan pada variabel jenis kelamin dan asal-usul daerah tidak terdapat perbedaan persepsi mahasiswa tentang CSR

Effect of Myo-inositol and N-acetyl-L-cysteine on processed human spermatozoa for use in modern methods of fertility treatment

Background and aims: Today, the prevalence of structural and functional disorders of sperm and subsequently the possibility of occurrence of autism, spontaneous abortion, and infertility has increased dramatically. This study aimed to investigate the potential effects of myoinositol and N-acetyl-L-cysteine (NAC) on the improvement of processed spermatozoa indices. Methods: In this study, 63 patients with male factor infertility were studied in Hazrat Zahra Infertility Center of Shahrekord. To do liquefaction, the semen sample was incubated at 37°C for 20 minutes. The Density Gradient Centrifugation protocol was used to process sperm. The processed sperm samples were incubated at 37°C for 20 minutes in four groups of control, myo-inositol (2 mg/mL), NAC antioxidant (10 Mm/L) and myo-inositol+NAC. All biological parameters of sperm were evaluated using Makler slide, SQA-V sperm analyzer gold version 2.48, TUNEL assay, and Toluidine blue staining. Results: In the present study, 63 men aged 22-58 years with infertility complaints were studied. The NAC group and the myo-inositol group exhibited significantly higher motility in comparison with the control group (P<0.001). The NAC group also had a significantly higher number of TUNEL-negative cells and a lower number of TUNEL-positive cells than the control group (P<0.01), but in other variables, the differences were not statistically significant. The morphology, S0, S1, S2 and staining types in the intervention groups did not show any significant difference compared to those in the control group (P > 0.05). Conclusion: NAC and myo-inositol were able to improve certain indices such as sperm motility and integrity; therefore, the quality of sperm could be improved by these drugs to treat infertility.

Microstructure and mechanical properties of powder metallurgy high temperature titanium alloy with high Si content

The service temperature of high temperature titanium alloy has been raised from 400 °C to 650 °C in the last years. In this study, a new near α high temperature titanium alloy with high Si content (Ti–6Al–4Zr-0.5Mo-0.6Si, wt. %) which can serve at 700 °C was developed by powder metallurgy (P/M) method. The microstructure and mechanical properties were investigated. The results show that the P/M titanium alloy exhibits an α + β two-phase microstructure with dispersed fine S2 type silicide ((TiZr)6Si3). The yield strength and ultimate tensile strength are 1023 MPa and 1190 MPa at room temperature, with an elongation of 10%. At 700 °C, the alloy still maintains a yield strength, an ultimate strength, and an elongation of 510 MPa, 651 MPa and 13%, respectively. The high strength is mainly attributed to the precipitation strengthening of the silicide and the formation of fine-grained α′ phase.