The purpose of the present contribution is to describe the prevalence of nervios through self-report, to identify psychological and somatic symptoms associated with nervios, and to report the comorbidity of nervios with mood and anxiety disorders among Mexican rural-origin adults. The data reported here were collected as part of a larger project, whose aims were to determine the prevalence of selected mental health problems, their sociocultural manifestation and interpretation, and the utilization of mental health services among the inhabitants of rural communities in Mexico. A multi-stage, stratified, random sample of two regions in Mexico was obtained. The total number of participants used in the analyses was 942 adults: 441 men and 501 women. We found a prevalence of nervios of 15.5% in the general population. When analyzed by sex, women had a significantly higher prevalence (20.8%) of this condition than men (9.5%). Also, all the somatic and psychological symptoms associated with nervios had a higher prevalence among women than men.