Land use and land cover changes, mostly driven by anthropogenic activities, affect the processes of the water cycle. The impacts of land use (LU) and land cover (LC) changes between 1995 and 2015 on the surface runoff of the Hadejia River System (HRS) were investigated. The LULC changes obtained through re-classifications of selected Landsat satellite images and their effects on runoff peak discharges and volumes were assessed using selected hydrologic models for runoff generation and routing available within the HEC-HMS. Physically-based parameters of the models were estimated from the LULC change maps together with a digital elevation model and soil datasets of the basin. The simulated flows from the 90 sub-catchments were routed to the basin outlet afterwards to obtain the accrued effects in the entire river basin. Model results obtained generally revealed significant and varying increases in the runoff peak discharges and volumes within some sub-basins in the whole catchment, though the change was not significant at the basin outlet. In the sub-catchments within Kano and Jigawa states, increase between 15-20% and 10-15% were observed in the peak discharge respectively. These are the areas with the highest increase in agricultural activities and urbanization within the whole catchment. In the entire basin, however, the flood peak discharges and volumes increased by at least 3.57% and 8.18% respectively. From these results, the study concludes that changes were more pronounced in Kano and Jigawa states due to the increase of urbanization and farming activities in those areas, leading to reduction of infiltration and hence, increase in surface runoff. The study successfully outlined the hydrological consequences of land cover changes, emphasizing the importance of sustainable land use and catchment management strategies. Hence, integration of remote sensing, GIS, and the hydrological model (HEC-HMS) can be used to solve hydrological problems in a river basin.