This study explores the ternary nanofluid flow within the canonical gap between a cone and a disk with particle deposition and magnetic field effects. Reduced titanium dioxide, magnetite, and graphene oxide are used as nanoparticles in the base fluid ethylene glycol. The governing equations of the problem are in the form of partial differential equations, which are converted to nonlinear ordinary differential equations by using appropriate similarity transformations, and they are solved numerically by using Runge–Kutta–Fehlberg fourth fifth-order (RKF 45) technique. The main agenda of this work is to discuss the impacts of parameters on three cases. The effects of essential aspects on fluid flow, heat and mass transfer rates were studied and analyzed using a graphical representation. Additionally, the response surface methodology and sensitivity analysis are carried out to enhance the importance of the heat transfer rate. The results reveal that the flow field increases significantly with increased Reynolds numbers for both cone and disk rotations. It is observed that the sensitivity analysis of the Nusselt number toward the Eckert number is more for all the radiation parameter values and the Eckert number’s middle level.