Industrial workplace design and evaluation is the outcome of a multi-factored process which requires diverse disciplines and interrelated techniques to consider alternative factors and to achieve an optimal design solution. However, it is still evident that industrial workplace design fails to incorporate ergonomic principles throughout all stages of design and evaluation, One approach to solve the problem is to introduce an expert system for integrating existing analytic models and expertises into a framework which guides the designer along the necessary steps to reach a solution, with explanations on its reasoning process. This paper discusses the framework of the prototype expert system being implemented using VM/PROLOG on IBM VM/CMS mainframe. The rule-based production system was selected as a representation scheme due to its versatility and expressive power. It is consisted of two main parts, First, modularized knowledge bases incorporate multidisciplinary ergonomic factors such as biomechanics, work physiology, and psychophysics. Each module stores knowledge either in the fact base or the rule base, however, massive experimental findings and table-lookups are separately stored in the external database through its interface and retrieved without bothering the main inference mechanism. Secondly, inference mechanism was built as a control mechanism, with a front-end user interface. It has a pattern-directed architecture coupled with a normal forward/backward chaining mechanism. The prototype expert system also incorporates analytical models (usually written in FORTRAN) into the reasoning process so that it is highly flexible to the problem specificity.