The “one-pot” cascade process involves multiple catalytic conversions followed by a single workup stage. This method has the capability to optimize catalytic efficiency by reducing chemical processes. The key to achieving cascade reactions lies in designing cascade catalysts with well-dispersed, stably immobilized, and accessible noble metal nanoparticles for multiple catalytic conversions. This work presents a strategy for creating long-lasting cascade catalysts by encapsulating Ru and Pd nanoparticles within multi-shell spongy-core porous microspheres (MS-SC-PMs). This cascade catalyst strategy enables the continuous hydrogenation of nitrobenzene to aniline and further to cyclohexylamine, demonstrating both high selectivity and conversion rates. Notably, this approach overcomes the typical challenges associated with noble metal nanoparticles, such as poor stability and recyclability, as it maintains its performance over ten consecutive cycles. Additionally, the MS-SC-PMs have the versatility to encapsulate various metal nanoparticles, providing catalytic versatility, scalability, and a promising avenue for designing long-lasting catalysts loaded with nanoparticles.