Data for the delivery of total species containing parent drugs from water through hairless mouse skin by prodrugs, log J MMAQ, has been fitted to the Roberts–Sloan, RS, the Kasting–Smith–Cooper, KSC, and Magnusson–Anissimov–Cross–Roberts, MACR, equations. The RS model which contains a parameter for the dependence of flux on solubility in water, S AQ, as well as solubility in the lipid isopropyl myristate, S IPM, gave the best fit: log J MMAQ = −2.30 + 0.575 log S IPM + 0.425 log S AQ − 0.0016 MW, r 2 = 0.903. The values for the coefficients to the parameters are quite similar to those obtained when the RS model was fit to flux of solutes from water through human skin, log J MHAQ. There was no trend in predicting the under or over-performance of prodrugs based on their fit to the RS model and whether they were more or less soluble than their parent drugs. There was an inverse dependence of log J MMAQ on partition coefficients or permeability coefficients similar to that observed for log J MHAQ. The similarities in trends for results for log J MMAQ and log J MHAQ suggests that design directives obtained from mouse skin can be extended to design new prodrugs or select new drugs for delivery through human skin.