With the increase of the height of the filled slope, the application of multiple combination retaining structures (MCRS) is becoming more and more popular. However, the traditional design methods seldom consider the coupling effects between the substructures. To investigate the interaction of MCRS, this paper takes the filled slope project of a middle school in Quanzhou City, Fujian Province, China as an example. The filled slope was supported by MCRS, including reinforced soil, doublerow piles, anchors and counterfort retaining walls. The simulate procedure mainly included the following process: first, the MCRS model was established, then the mechanical response of the MCRS when replacing the fill materials and increasing the length of the rear row piles were obtained, and a comparative analysis was carried out. The following conclusions could be drawn: (1) The properties of backfill material have a significant impact on the displacement of backfill slope, and when the backfill is gravel soil, the displacement of slope can be controlled to a satisfactory degree. When the back-fill soil is replaced by silty clay, the shear strength and internal friction angle of soil become smaller, thus the displacement of slope increases significantly, which may lead to slope failure. (2) When the anchorage length is satisfied, increasing the length of the rear row pile has no significant effect on reducing the displacement of MCRS slope, but it can effectively reduce the axial force of anchor rod. (3) In MCRS, each substructure has complex interaction, and numerical simulation provides an effective means for accurate evaluation of MCRS.