The article considers the issues of development of a smart system for supporting activities of ROV operators and its practical implementation for the efficient operation a ROV Comanche 18 that is based on the R/V Akademik M.A. Lavrentiev. The system uses algorithms that provide coordinated movements of the ROV and its depressor unit. These algorithms are designed for ROVs to make synchronous, accurate, and accident-free movements along long-distance routes even when launched from a support vessel without dynamic positioning (DP). For this, the operator receives real-time visual recommendations and warnings generated on the basis of the expert evaluation of information coming from various sensors and positioning systems. The ability to plan routes of the ROV and its mothership, inputting target points, saving maps, tracks, and locations of the detected underwater objects are also implemented in the designed system. The article presents the results of successful tests carried out during a deep-sea research expedition of the A.V. Zhirmunsky National Scientific Center of Marine Biology FEB RAS in the Bering Sea and Pacific Ocean. The created smart support system for ROV operators significantly extends the range of capabilities of ROVs performing many unique underwater operations, while significantly reducing their operating time.