ABSTRACT Vitamin D is a generic term that encompasses a group of fat-soluble compounds. Very few foods naturally contain vitamin D. Assessing serum 25-hydroxy-vitamin D (25(OH)D) is the only way to make the diagnosis of vitamin D deficiency, whose prevalence varies based on how deficiency is defined. Given the current evidence, the benefits of large screening programs to detect vitamin D deficiency are not recommended. The clinical manifestations of vitamin D deficiency depend upon the severity and duration of the deficiency and appears restricted to the muscular-skeletal system. Two treatment modalities currently exist for vitamin D deficiency: sunlight and vitamin D supplementation. With regards to SARS-CoV-2 infection there is no clear evidence that supplementation reduces the risk, severity of infection, length of hospital stay or mortality. Due to the lack of good quality RCTs, routine supplementation of vitamin D for extra-skeletal benefits is NOT recommended.