Quantification of trace and minor nutrient elements is crucial for maintaining human health. A reliable laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) method for food materials was developed by combining fine food powder (dm < 3 μm) pellets as the external standard with an average C content as the internal standard (IS). The finer and homogeneous aerosol produced by ablating the fine powder pellets is beneficial for transportation and analyte ionization in ICP, which helps alleviate the matrix effects and improves the analytical precision and accuracy. The average C content is 39.9 ± 1.9% for plant-derived foods (n = 22) and 46.9 ± 1.1% for animal-derived foods (n = 7). The accuracy (recovery, 80-120%) and precision (RSD, 0.5-9.8%) were validated by analyzing a series of food certified reference materials. The high-throughput method is a promising alternative for routine sample analysis in food safety laboratories.