It is a well known fact that anemia is frequently present in cases of intestinal helminthiasis. Numerous cases of severe anemia, clinically indistinguishable from pernicious anemia, have been reported by clinicians and ascribed to the presence of various intestinal parasites, the removal of the parasites by anthelmintic medication resulting in an amelioration of the symptoms and eventually in complete recovery. That the broad tapeworm ( Diphyllobothrium latum ) and hookworms ( Necator americanus and Ancylostoma duodenale ) may cause an anemia has been recognized for a long time. That other intestinal parasites, notably the large intestinal roundworm ( Ascaris lumbricoides ) and the whipworm ( Trichuris trichiura ), may likewise be destructive to the erythrocytes of the host has not been generally recognized although certain parasitologists have from time to time called attention to this point. While the loss of blood in cases of infestation with nematodes may be accounted for in part as a result of the
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