The utility of contact lenses is increasing globally, with their use extending to therapeutic, cosmetic, and drug delivery purposes for ocular infections. However, due to improper hygiene, poor handling techniques, and extended wear, about 63% of contact lens wearers worldwide have been affected by ocular microbial infections. This has led to increased microbial resistance to ocular drugs, prompting the development of nano-based contact lens care solutions. 2D boron nanosheets have gained significant attention due to their structural similarity to graphene. The present study focuses on synthesizing boron nanosheets from the precursor MgB2 by bio-exfoliation of MgB2, utilizing plant parts of Pisonia grandis, Plantago ovata, Annona reticulata, Cyanodon dactylon, where the Mg atoms are selectively chelated and boron layers are exfoliated to form boron nanosheets. The synthesized boron nanosheets are characterized and analyzed for its anti-bacterial activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia of which boron nanosheet possess selective zone of inhibition against B. cereus. The toxicity of boron nanosheets has been analyzed using Artemia salina, where boron nanosheets are less toxic. Boron nanosheets with good antibacterial properties and less toxicity have been further analyzed for their potential use as contact lens care solutions where various parameters, including Light transmittance, Wettability, Surface roughness, Antibacterial activity, and other physicochemical properties were analyzed. The results indicate that boron nanosheets could be effectively used as contact lens care solutions for bacterial infections. This study serves as a platform for further exploration of 2D boron nanosheets in ocular drug delivery systems.
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