In-situ stress plays a pivotal role in controlling both the propagation speed and trajectory of blast-induced cracks. Previous studies have primarily placed emphasis on the qualitative analysis of the propagation morphology of such cracks, but the principal stress axis rotation effect under static-dynamic coupling loading was ignored. Consequently, the mechanical mechanism of the propagation of blast-induced cracks has not been figured out yet. In this study, a combination of laboratory tests, theoretical analysis, and numerical simulations was employed to explore the influence mechanism of the principal stress axis rotation effect on the propagation of blast-induced cracks under in-situ stress. The results suggest that the hydrostatic pressure does not change the propagation trajectory of blast-induced cracks, but a higher hydrostatic pressure will inhibit both their propagation speed and length. In contrast, the deviatoric stress can change the propagation trajectory of blast-induced cracks, and a higher deviatoric stress makes it easier for blast-induced cracks to deflect to the maximum loading stress direction. Besides, the propagation of blast-induced cracks exhibits different features in different stages under in-situ stress. In the zone near the blast source, the dynamic stress is dominant; the maximum principal stress of the mass points is distributed in the radial direction; and blast-induced cracks expand mainly along the radial direction. On the contrary, in the zone far from the blast source, the static load is dominant; the maximum stress direction of the mass point alters to the maximum loading stress direction; and blast-induced cracks deflect from the radial direction to the maximum loading stress direction. Therefore, the propagation of blast-induced cracks under in-situ stress is a dynamic process in which dynamic and static stresses compete for crack initiation, and the changes in both stress value and principal stress direction are identified as the main reasons for the deflection of blast-induced cracks.