Drilling of carbon/carbon (C/C) composites is difficult to carry out due to its high specific stiffness, brittleness, anisotropic, non-homogeneous, and low thermal conductivity, which can result in tear, burr, poor surface quality, and rapid wear of tools. Three drilling methods including conventional twist drilling, rotary ultrasonic drilling, and high-speed drilling can all be used in hole making of composites in industry. To find a best method of hole making in drilling of C/C composites, a serials of comparison experimental tests using the same size cemented carbide drill are designed and performed in this paper. Thrust force, tool wear, and drilling defects are all analyzed and compared for different machining parameters for all the three drilling methods. The experimental results show that rotary ultrasonic drilling is the best choice in almost all these aspects in drilling of needle-punched C/C composites within the range of selected experimental machining parameters.