We read the interesting article by Herrmann et al. on the use of reflectance confocal microscopy (RCM) to measure sensory neuropathy.1 Cutaneous innervation studies which evaluate the last endings of nerve fibers are useful in the early diagnosis of sensory neuropathies that share a “dying back” progression. We observed some conditions including small fiber neuropathies and Ross syndrome in which the neuropathic process seemed confined to cutaneous receptors.2,3 The availability of a noninvasive method to evaluate the density of Meissner corpuscles (MC) could be a powerful tool in revealing a sensory defect. As observed by the authors, the mean values of MC density (12 ± 5.3/mm2) obtained using RCM are lower than values we obtained using immunohistochemistry (33 ± 13.2/mm2).4 But if we correct the absolute values for tissue shrinkage (correction factor = 0.45), we obtain figures similar to those of Herrmann and colleagues. However, we evaluated the third fingertip where density is even lower than in the fifth fingertip.4,5 Therefore the two methods provide different MC counts. Part of this discrepancy can be attributed to the possibility that RCM misses some corpuscles. Authors observed zero, one, and occasionally two corpuscles …