Objectives: This study is a research carried out to confirm the influences of the stress, self-esteem, and verbal anger behavior as the factors to impact on depression of Korean university students. Methods/Statistical Analysis: In order to get data, a survey was conducted to 180 college students in a city. Scales of Beck’s depression, Rosenberg's self-esteem, perceived stress, and Chambers’ verbal anger behaviors were used. In order to verify the correlations among variables were tested utilizing Pearson's correlation coefficients, and multiple linear regression analyses were performed using the SPSS/PASW 22.0 program. Findings: Findings from the analyses are as follows; (1) Depression had a very strong positive correlation with stress (r=.881, p .050). (2)The high impact variable affecting the depression was stress (β=0.589), with the R squared of the model being 69.5 (F=102.505, p<.001).Depression among university students had a very strong positive correlation with stress. And self-esteem was identified as having the most negative impact on depression. Improvements/Applications: These findings will give useful information for constructing an intervening and preventative program focused on anger, stress, self-esteem and depression in the university students.