Early drought is a great threat limiting wheat production in semi-arid region resulted in poor emergence and weak seedlings. This research experiment attempts to evaluate the drought-tolerance potential of four local Triticum durum L. genotypes at germination stage. Hawler-1, Akassad, Semito and Barcelona subjected to drought stress of about 25 % of the soil water holding capacity (SWHC) and compared to their control 100 % SWHC in a factorial experiment designed in a complete randomization. Under stressed condition Semito genotype showed the significantly highest final germination percentage 54.66 %. Lowest MGT was 12 recorded by Semito and Aksaad. The heaviest roots, shoot dry weight and root: shoot ratio were observed in Akassad; 4.09 and 3.95 g and 1.28 respectively. The longest shoot averaged over all treatments was observed in Semito (23.05 cm). The highest leaves relative water content (LRWC) and membrane stability index (MSI) were 56.39 and 62.05 recorded by Semito. Akassad had the highest content of chlorophyll a, b and total; 2.40, 1.51 and 3.91 mg/ g fresh weight. Highest significant proline content was 0.548 mg/ g fresh and sugar content was 2.94 mg g dry weight accumulated in Semito leaves. Genotypes with a fast germination, more vigorous root system and highest root: shoot ratio are very desirable for the rapid establishment of seedlings and could have best physiological response as well as accumulate more osmoticum in their cytosol. Thus, Akassd and Semito had best potential adaptability to drought stress at early growth stage.