The aim of this study was to perform an integrative review on the layer thickness and microstructure of resin-matrix cements around custom-made or standard teeth root intracanal posts. An electronic search was conducted on the PubMed using a combination of the following scientific terms: intraradicular post, root intracanal post, resin cement, thickness, adaptation, endodontic post, layer thickness, fit, shape, and endodontic core. The literature selection criteria accepted articles published in the English language, up to May 2021, involving in vitro analyses, meta-analyses, randomized controlled trials, and prospective cohort studies. The search identified 154 studies, of which 24 were considered relevant to this study. The selectedstudies provided important data considering cement layer thickness, tooth preparation, endodontic post, and type of resin-matrix cement. The anatomical variability of root canal systems, such as the oval- orC-shaped, represents a challenge in dental restoration with tooth root intracanal posts. The fitting of intracanal posts to different rootregions is variable resulting in thick and irregular layers of resin-matrix cement. Defects like pores, micro-cracks, and micro-gaps were detected in the resin-matrix cement microstructure and represent spots of stress concentration and fracture. Custom-made tooth rootintracanal posts provide a proper fitting and decrease the layer thickness of resin-matrix cement. In fact, the layer thickness of resin-matrix cements depends on the fitting of endodontic posts to tooth root canals. An increase of resin cementthickness causes the appearance ofdefects like pores, micro-cracks, and micro-gaps that can induce stress concentration and fractures at interfaces. The fitting of the endodonticpost into the teeth root canal determine the layer thickness of the resin-matrix cement to establishan adequate retention.However, the increase in the thickness of the resin-matrix cement layer can lead to a high number of defects like pores or cracks and therefore decrease the strength of the interface.