Root Resorption Of Permanent Teeth Research Articles

Root resorptions induced by genetic disorders: A systematic review.

Root resorption in permanent teeth is a common pathological process that often follows dental trauma or orthodontic treatment. More rarely, root resorption is a feature of genetic disorders and can help with diagnosis. Thus, the present review aims to determine which genetic disorders could induce pathological root resorptions and thus which mutated genes could be associated with them. We conducted a systematic review following the PRISMA guidelines. Articles describing root resorptions in patients with genetic disorders were included from PubMed, Embase, Web of Science, and Google Scholar. We synthesized the genetic disorder, the type, severity, and extent of the resorptions, as well as the other systemic and oral symptoms and histological features. The synthetic analysis included 25 studies among 937 identified records. We analyzed 21 case reports, three case series, and one cohort study. Overall, we highlighted 14 different pathologies with described root resorptions. Depending on the pathology, the sites of resorption, their extent, and their severity showed differences. With 14 genetic pathologies suspected to induce root resorptions, our findings are significant and enrich a previous classification. Among them, three metabolic disorders, three calcium-phosphorus metabolism disorders, and osteolysis disorders were identified.

Root Resorption in the Permanent Teeth. A Review

The loss of dental hard tissue as a result of odontoclastic activity is known as root resorption. It is unwanted and pathological in permanent teeth. Root resorption may happen within the root canal called internal root resorption or on the outer surface of the root called external root resorption. Regardless of where it occurs, root resorption is irreparable, can cause pain for the patient, necessitates treatment, and in some circumstances, resulting in the early loss of the affected tooth. It might be challenging to precisely diagnose and treat root resorption. There is limited information within literatures on root resorption therefore this review aims to understand the radiological and clinical characteristics of root resorption with evaluation of their effect in accurate diagnosis and management of root resorption in permanent teeth.

Pathogenesis of non-infection related inflammatory root resorption in permanent teeth: A narrative review.

The mechanism of action of root resorption in a permanent tooth can be classified as infection-related (e.g., microbial infection) or non-infection-related (e.g., sterile damage). Infection induced root resorption occurs due to bacterial invasion. Non-infection-related root resorption stimulates the immune system through a different mechanism. The aim of this narrative review is to describe the pathophysiologic process of non-infection-related inflammatory processes involved in root resorption of permanent teeth. A literature search on root resorption was conducted using Scopus (PubMed and Medline) and Google Scholar databases to highlight the pathophysiology of bone and root resorption in non-infection-related situations. The search included key words covering the relevant category. It included in vitro and in vivo studies, systematic reviews, case series, reviews, and textbooks in English. Conference proceedings, lectures and letters to the editor were excluded. Three types of root resorption are related to the non-infection mechanism of action, which includes surface resorption due to either trauma or excessive orthodontic forces, external replacement resorption and external cervical resorption. The triggers are usually damage associated molecular patterns and hypoxia conditions. During this phase macrophages and clastic cells act to eliminate the damaged tissue and bone, eventually enabling root resorption and bone repair as part of wound healing. The resorption of the root occurs during the inflammatory phase of wound healing. In this phase, damaged tissues are recognized by macrophages and neutrophiles that secrete interlaukines such as TNF-α, IL-1, IL-6, IL-8. Together with the hypoxia condition that accelarates the secretion of growth factors, the repair of the damaged perioduntiom, including damaged bone, is initiated. If the precementum and cementoblast are injured, root resorption can occur. Wound healing exhibits different patterns of action that involves immune stimulation in a bio-physiological activity, that occurs in the proper sequence, with overlapping phases. Two pathologic conditions, DAMPs and hypoxia, can activate the immune cells including clastic cells, eliminating damaged tissue and bone. Under certain conditions, root resorption occurs as a side effect.

Lateral Incisor Root Resorption: A Consequence of Ectopic Maxillary Canine Teeth

Root resorption of permanent teeth is a recognized complication of ectopic maxillary permanent canines. This type of resorption is sometimes missed and can be diagnosed at the late presentation stage. Treatment of external resorption is complex and can require extraction of the affected tooth. This review provides an insight into the current evidence and guidance related to the interceptive treatment of displaced permanent maxillary canines to minimize the risk of resorption of adjacent teeth. Supported by two clinical cases, it looks into treatment options and long-term management of lateral incisors with external root resorption of varying severities. CPD/Clinical Relevance: Primary care practitioners are best placed to recognize displaced maxillary permanent canines in a timely manner, and so, root resorption of adjacent teeth may be prevented.

Profile of intrusive luxation and healing complications in deciduous and permanent teeth – a retrospective study

Objective: This retrospective study analyse the profile of intrusion in deciduous (DT) and permanent teeth (PT), the occurrence of healing complications (HC), type of treatments and predisposing factors.Methods: The records of patients attended from 2005 to 2011 were analysed. Records of patients who had one or more intruded DT or PT were included in the study. Data collected from dental records included age, gender, attendance (immediate/mediate), healing complications and type of treatment. A Chi-square test and Logistic regression (p ≤ .05) were performed to evaluate the associations between the type of teeth and presence of HC, as well as to explore the interactions between predisposing factors.Results: The intrusion prevalence was 9.98% in DT and 2.45% in PT. Partial intrusion (57.3%) with palatal direction of the crown (61.8%) was most prevalent in DT, while complete intrusion (56.7%) with buccal direction of the crown (58.1%) was predominant for PT. Mobility was the most common HC in DT compared to root resorption in PT. Minimally invasive treatments were the most common therapy for DT compared to invasive treatments for PT. PT demonstrated increased HC when compared to DT (p = .004). A logistic regression illustrated that the level of intrusion and crown direction during the trauma did not influence the occurrence of HC (p > .05).Conclusion: Intrusion’s profile in DT and PT are different. PT showed more HC than DT, however the level of intrusion and crown direction were not associated with the presence of HC.

Relationship between Initial Attendance after Dental Trauma and Development of External Inflammatory Root Resorption.

This clinical study aimed to evaluate the relationship of the delay between dental trauma and the initial attendance to the development of external inflammatory root resorption in permanent teeth affected by severe luxation. Sixty-seven patients, aged between 11 and 56 years, presenting 133 injured teeth with closed apex (56 extrusive luxation, 69 lateral luxation and 8 intrusive luxation) were followed up for a minimum of 24 months. The time elapsed between dental trauma and the initial attendance was recorded. The presence of necrotic pulp and external inflammatory resorption for each type of trauma was verified. Fisher's exact test was used to verify the influence of the initial attendance date at the Dental Trauma Center and the development of inflammatory resorption (p<0.05). The odds ratio was used to check the risk of developing external inflammatory resorption due to delay in seeking treatment. Pulp necrosis was observed in 105 teeth (78.9%) and external inflammatory resorption was detected in 17.8% cases of extrusive luxation (10 teeth), 15.9% of lateral luxation (11 teeth) and 25% of intrusive luxation (2 teeth). For lateral luxation, extended delay between the date of injury and initial attendance influenced the occurrence of external inflammatory resorption (p=0.0174). Patients who began treatment 45 days after the injury were 3.4 times more likely to develop external inflammatory resorption than patients who sought treatment after the trauma. Treatment late after the occurrence of dental trauma can impair the prognosis and result in the development of external inflammatory resorption in luxated teeth.

Anti-dentine Salivary SIgA in young adults with a history of dental trauma in deciduous teeth.

Anti-dentin autoantibodies are associated with inflammatory root resorption in permanent teeth and are modulated by dental trauma and orthodontic force. However, it is not known whether deciduous tooth trauma can stimulate the development of a humoral immune response against dentin. The aim of this study was to evaluate the levels of salivary SIgA reactivity against human dentin extract in young adults with a history of trauma in the primary dentition. A sample of 78 patients, aged 18 to 25, who had completed an early childhood (0 to 5 years old) caries prevention program years earlier at the Universidade Estadual de Londrina Pediatric Clinic, underwent radiographic examination and salivary sampling. Anti-dentin SIgA levels were analyzed by immunoenzymatic assay and Western blotting. Although dental trauma to deciduous teeth had occurred in 34 (43.6%) of the patients, no differences in SIgA levels were detected between individuals who had experienced trauma and those who had not (p > 0.05). Multivariate regression analysis showed no association between dental trauma and SIgA levels (p > 0.05). Patients with a history of deciduous trauma presented low levels of anti-dentin antibodies, associated with orthodontic root resorption (p < 0.05). Western blot analysis showed that salivary antibodies recognized a single band of approximately 45 kDa in dentin extract. We concluded that salivary SIgA recognizes a specific component of the dentin matrix and that anti-dentin antibodies were not triggered by trauma to primary teeth. However, trauma to deciduous teeth may down-modulate SIgA in response to orthodontic root response.

Calcific Metamorphosis with Pathological Root Resorption in Permanent Teeth: Morphohistometric Evaluation of Two Cases

La Metamorfosis Calcificante (MC) es una respuesta pulpar a traumatismos dentales, caracterizada por un deposito de tejido duro dentro del canal pulpar. Un diente con MC usualmente presenta un cambio en el color y una obliteracion parcial o total del espacio del canal pulpar, y sus respuestas a las pruebas de vitalidad y los mismos sintomas suelen ser de dificil diagnostico. Dado que la necrosis pulpar no puede ser supuesta aun con respuestas negativas, el estado periradicular es el unico criterio diagnostico confiable. Dos dientes permanentes de dos pacientes masculinos (de 22 y 53 anos) diagnosticados con MC asociada a reabsorcion patologica de la raiz, extraidos por movilidad severa fueron preparados y seccionados para evaluacion histologica e histometrica. Las imagenes fueron capturadas, procesadas y medidas en un mapeo total para cada especimen utilizando software Pinnacle Studio 9.4® (Pinnacle Systems Inc.), Adobe® Photoshop® (CS 8.0.1, Adobe Systems Inc.) e Image J® (National Institute of Health, Bethesda, MD, USA). Las imagenes demostraron la concurrencia de MC y reabsorcion radicular. Las medias de las mediciones totales expusieron que la superficie de afeccion radicular (R) fue mayor que la de afeccion coronaria (C), tanto en cantidad (R: 13,75 mm2 -28,75%-/C: 4,7 mm2 -5,47%-) como en calidad and (R: ausencia de MC / C: presencia de MC). La MC mostro patrones de fibrosis, de tejido similar a un hueso cortical y a un hueso esponjoso, representando una forma de reaccion reparativa iniciada probablemente en el proceso de reabsorcion. La concurrencia entre MC y reabsorcion patologica radicular es rara en el mismo diente, y la posibilidad de obtener especimenes de dientes permanentes para evaluarlos histologica e histometricamente es aun menos frecuente. Esta evaluacion histometrica permitiria expandir el espectro de variables utiles para la toma de decisiones clinicas y terapeuticas odontologicas.

Esthetic management of multiple missing anterior teeth – A Case report

The aim of this case report was to present management of a case of multiple apical root resorptions due to orthodontic treatment in a 27-year-old adult female using implant supported crowns. External root resorption of the permanent teeth is a multi-factorial process. Well recognized causes of apical root resorption in permanent teeth include orthodontic therapy, trauma, periapical or periodontal inflammation, tumors, cysts, occlusal stress, impacted teeth, systemic conditions, endocrine imbalances and dietary habits. This case report presents esthetic management of missing central incisors using gingival porcelain for esthetics without using any augmentation procedure.

Using MTA in the treatment of internal and external root resorption of permanent teeth – report on own observation

Using MTA in the treatment of internal and external root resorption of permanent teeth – report on own observation

Extensive Idiopathic External Apical Root Resorption on a 13 Year Old Child

External root resorption in permanent teeth can occur as a result of a multitude of local and systemic factors. Root resorption that is idiopathic or occurring without any identifiable underlying cause is an unusual phenomenon, especially in children. This article describes a rare case of extensive external apical root resorption affecting multiple teeth and occurring concomitantly with localized periodontitis in a 13 year-old child. No significant systemic, local or familial findings could be identified as a plausible cause for the root resorption.

Bovine dentine organic matrix down-regulates osteoclast activity

Physiological root resorption is a phenomenon that normally takes place in deciduous teeth; root resorption of permanent teeth occurs only under pathological conditions. The molecular mechanisms underlying these processes are still unclear. Our previous study showed that osteoclasts cultured on deciduous dentine exhibited a higher degree of resorption and higher levels of cathepsin K and MMP-9 mRNA than osteoclasts cultured on permanent dentine. These results could be because of different susceptibilities to acid and the different organic matrices between deciduous and permanent dentine. Thus, the purpose of this study was to investigate the effect of dentine extracts from bovine deciduous and permanent dentine on osteoclast activity. Osteoclasts, obtained from mouse bone marrow cells co-cultured with an osteoblast-rich fraction in the presence of 1,25-(OH)(2)-vitamin D3 and PGE2, were incubated with or without 0.6 M HCl extracts from bovine deciduous or permanent dentine for 48 h. TRAP positive cell number, TRAP activity, the areas of resorption pits, and mRNA levels of TRAP, v-ATPase, calcitonin receptor, cathepsin K, and MMP-9 were examined. The results illustrated that TRAP activity, the resorbed area, and the mRNA levels of osteoclast marker genes seemed to be suppressed by both deciduous and permanent dentine extracts. These findings indicate that some factors that suppress osteoclast activity are contained in both deciduous and permanent dentine extracts. Although there was no significant difference in osteoclast activity between deciduous and permanent dentine extracts, osteoclasts incubated with permanent dentine extracts tend to exhibit less resorption activity than those incubated with deciduous dentine extracts. However, we could not clearly explain the causes of this.

A case of multiple idiopathic external root resorption: A 6-year follow-up study

Multiple idiopathic external root resorption of permanent teeth is a very infrequent phenomenon. This paper describes a case of multiple idiopathic external root resorption at cement-enamel junction in 21 of 25 teeth followed up for 6 years. In addition to clinical features and radiographs, we present results of histological and bacteriological examinations.

Does the canine dental follicle cause resorption of permanent incisor roots? A computed tomographic study of erupting maxillary canines.

We performed computed tomography (CT) on 107 children and adolescents aged 9-15 years with 176 unerupted maxillary canines (152 erupting ectopically and 24 erupting normally) to determine whether there is an association between widened dental follicles of the maxillary canines and resorption of the adjacent incisors during eruption. Contiguous axial (transverse) CT scans were obtained through the maxilla in the region of the canines. The width and shape of the dental follicles were recorded, as were any contacts between the follicles and the crowns of the maxillary canines and neighboring incisors. Fifty-eight lateral incisors (38%) and 14 central incisors (9%) had some type of root resorption. The position of the maxillary canine in relation to the root of the lateral incisor varied greatly, as did the width and shape of the canine dental follicle. Follicle width ranged from 0.5 mm to 7.0 mm. The mean +/- SD width of dental follicles was, on average, larger for the ectopically positioned canines (2.9 +/- 0.8 mm) than for the normally erupting canines (2.5 +/- 0.8 mm) (P < or = .01). We found that during eruption, the follicle of the erupting maxillary canine frequently resorbed the periodontal contours of adjacent permanent teeth but not the hard tissues of the roots. We concluded that the dental follicle did not cause root resorption of permanent teeth. Resorption of neighboring permanent teeth during maxillary canine eruption was most probably an effect of the physical contacts between the erupting canine and the adjacent tooth, active pressure during eruption, and cellular activities in the tissues at the contact points, all of which are part of the eruptive mechanism. The findings also confirm an association between root resorption of deciduous canines and the dental follicles of erupting permanent canines.

Root resorption after orthodontic treatment: Part 2. Literature review

All permanent teeth may show microscopic amounts of root resorption that are clinically insignificant and radiographically undetected. Root resorption of permanent teeth is a probable consequence of orthodontic treatment and active tooth movement. The incidence of reported root resorption during orthodontic treatment varies widely among investigators. Usually, extensive resorption does not affect the functional capacity or the effective life of the tooth. Most studies agree that the root resorption process ceases once the active treatment is terminated. Root resorption of the deciduous dentition is a normal, essential, and physiologic process. Permanent teeth have the potential to clinically undergo significant external root resorption when affected by several stimuli. This resorptive potential varies in persons and between different teeth in the same person. This throws doubt on the role of systemic factors as a primary cause of root resorption during orthodontic treatment. Tooth structure, alveolar bone structure at various locations, and types of movement may explain these variations. The extent of treatment duration and mechanical factors definitely influence root resorption. In most root resorption studies, it is not possible to compare the results and conclusions because of their different methods. Further research in this field is necessary to advance the service of the specialty. The question of whether there is an optimal force to move teeth without resorption or whether root resorption may be predictable remain unanswered. This review indicates the unpredictability and widespread incidence of the root resorption phenomenon.(ABSTRACT TRUNCATED AT 250 WORDS)

Idiopathic root resorption: Report of a case

A ccording to Shafer, Hine, and Levy,l root resorption of permanent teeth can be attributed to a wide variety of causes, such as periapical inflammation, reimplantation of teeth, tumors and cysts, excessive mechanical or occlusal stresses, impaction of teeth, and idiopathic resorption. Stafne and Slocumb2 have presented data indicating that the maxillary and mandibular central incisors are most frequently involved by idiopathic root resorption. According to the data of Massler and Perreault,3 the teeth most commonly involved by root resorption were the maxillary premolars, whereas the mandibular incisors and molars exhibited the least resorption. Of the 179 cases reported by Stafne and Slocumb,* only nineteen showed the involvement of more than one tooth by idio’pathic root resorption. In seventeen cases two teeth were involved, and in two cases three teeth were involved ; furthermore, the maxillary molars were not found to be affected by idiopathic root resorption. Sachs4 has reported a case in which a right maxillary molar and bilateral mandibular molars were involved. Because cases of idiopathic root resorption have rarely been reported, it is the purpose of this article to add au additional case to the literature.

A Comparative Study in Root Resorption in Permanent Teeth

A Comparative Study in Root Resorption in Permanent Teeth

A preliminary report of an investigation of apical root resorption of permanent teeth

A preliminary report of an investigation of apical root resorption of permanent teeth

矯正科永久齒ノ根尖端竝吸収ニ對スル研究ノ豫備的報告

矯正科永久齒ノ根尖端竝吸収ニ對スル研究ノ豫備的報告