Role Of Mediator Research Articles

Structural Modeling of Alexithymia Relationships and Bullying Rate of Students with Mediation of Their compatibility

Introduction: Bullying is a kind of low-level violence that has recently attracted the attention of researchers and psychologists in the field. The purpose of this study was to investigate the modeling of structural relationships between Alexithymia and bullying with the role of mediator of students' adaptationin students.M ethods: Correlational research based on structural equation modeling technique, in particular regression equations (combining path analysis and factor analysis Second level). The statistical population consisted of all female students of the Humanities Department of Payame Noor University of Sari in the academic year of 2018-19. In this research, 401 students were selected as a sample by multistage cluster random sampling. Data gathering tools were Patchin and Hendowjah's Bullying Questionnaire (2011), Emergency Neural Network (1994), Baker and Siriac compatibility (1984). Resulth: The findings showed that the research model was confirmed and in general, 36 percent of students' bullying could be explained by student Alexithymia and student adaptation. Also, Alexithymia and student adaptation variables have a direct direct effect on students 'bullying. Emotional neural pathology has an indirect effect on students' bullying, with regard to student interpersonal mediation. Conclusion: The results of this study emphasized the importance of Alexithymia with regard to the quality of student compatibility., which can provide practical implications for reducing the level of bullying to counselors and psychologists, and considering the findings of the study can be used to reduce the incidence rate. Bullying among students has led to increased levels of academic compatibility as well as identification and correction of students' Alexithymia.

Hospitalization Experience of Muslim Migrants in Hospitals in Southern Spain-Communication, Relationship with Nurses and Culture. A Focused Ethnography.

The coast of southern Spain is one of the main entry points for Africans who want to reach Europe; in this area, there is an important immigrant community of African origin, mostly Muslims. The objective of this study is to describe and understand the hospitalization experience of Muslim migrants in public hospitals in southern Spain, especially their relationship with the nurses who care for them. Data were collected from May 2016 to June 2017. This study followed the principles associated with focused ethnography. During data collection, open interviews with 37 Muslim patients were conducted. Three themes emerged from the inductive data analysis: lack of communication with nurses, discriminatory experiences at the hospital and their experience of Islam in the hospital. We conclude that caring for Muslim patients requires specific training not only for nurses but also for other health professionals; existing communication problems must be addressed by establishing the role of the intercultural mediator as an idiomatic and cultural bridge between patients and nurses. In addition, hiring health professionals with migrant backgrounds would help convert hospitals into spaces for intercultural coexistence.

Exploring market overreaction, investors’ sentiments and investment decisions in an emerging stock market

The representative heuristic and overconfidence are cognitive biases that influence the decisions of the investors in the stock market. Overconfident investors tend to rely on representative heuristic for decision making under uncertainty. Investors overestimate their knowledge and think that past performance is the best indicator to measure the future performance of a company. Investors who are overconfident and use representative heuristics overreact to any new information that arrives in the market, and it affects their decisions. To measure the presence of overconfidence and representative heuristic in decisions making of investors trading at Pakistan Stock Exchange (PSX), we have used primary as well as stock market secondary data. Primary data was collected from 446 retail investors, and secondary data was collected from 301 companies listed in 35 sectors of PSX. We have found a significant effect of overconfidence and representative heuristic on the decision making of investors and the trade volume of the stock market. This paper adds to the literature of behavioral finance concerning the role of overconfidence as a mediator between representative heuristic and investment decisions. The evidence documented in this paper is first known to measure the role of mediator between representative heuristic and investment decisions.

A Study on the Impact of Perceived Characteristics of Augmented Reality(AR) Services on User Satisfaction and Intention to Use

본 연구에서는 최근 광고와 마케팅에서 활용되어 주목받고 있는 증강현실(AR: Augmented Reality) 서비스에 대한 채택모델을 검증하였다. 특히, 증강현실 서비스를 사용하는 이용자들의 지각된 특성이 증강현실 서비스에 대한 전반적인 만족과 향후 지속적인 이용의도를 갖는지 그 영향 관계에 대하여 탐색하였다. 연구결과 증강현실 서비스에 대한 지각된 특성을 실재감, 멀미감, 유희성, 유용성으로 구분하고, 만족감이 이를 매개하여 이용의도에 영향을 미치는지 검증한 결과, 유희성과 유용성만이 만족감에 유의미한 영향을 미치며, 만족감을 매개로 이용의도에도 유의미한 영향을 미치는 것으로 나타났다. 특히, 증강현실 서비스에서 멀미감과 실재감 요인이 유희성과 유용성에 비해 증강현실 서비스 이용에 있어서 덜 중요한 것으로 증명되어 가상현실 서비스와 증강현실 서비스의 채택을 설명하는데 다른 관점이 필요한 것으로 분석되었다. 이에 증강현실 서비스 산업의 활성화를 위해서 증강현실 서비스의 지각된 특성요인들 중 이용자들의 이용의도를 결정하는 요인을 밝힘으로써 품질이 높은 증강현실 서비스 구현 및 제작에 중요한 시사점으로 활용되길 기대한다.This study verifies an adoption model for augmented reality (AR) services, which have been attracting great attention recently in advertising and marketing. In particular, this study examines the relationship between the perceived characteristics of AR and users’ overall satisfaction, and also their intention to use AR services in the future. In this study, the characteristics of AR services were composed of presence, motion sickness, playfulness, and usefulness, and it was verified that user satisfaction plays the role of mediator between the perceived characteristics of AR services and intention to use AR services. More specifically, it was also proven that playfulness and usefulness are key factors in the intention to use AR services, but motion sickness and presence are not. It is expected that different perspectives are needed to explain the difference between the adoptions of VR and AR services. The findings in this study have important implications for the implementation and production of high-quality AR services by revealing the factors that determine the perceived characteristics of AR services and the relationship with the intention to use AR services.

Участь Арабської Республіки Єгипет у протидії тероризму на Близькому Сході за президентства А. Ф. ас-Сісі

У статті здійснено спробу аналізу участі Єгипту в протидії тероризму на Близькому Сході, що визначено одним із пріоритетів зовнішньополітичної стратегії держави за президентства А. Ф. ас-Сісі. Виявлено, що зовнішня політика Єгипту детермінується проблемами внутрішньополітичного розвитку після подій «Арабської весни». У протидії тероризму у регіоні Єгипет долучається до міждержавного співробітництва, бере участь у спільних військових навчаннях, антитерористичних операціях. Зокрема, заручившись підтримкою впливових країн в регіоні (Арабські Емірати та Саудівська Аравія) намагається посилити свій авторитет на Близькому Сході.

Specific functions for Mediator complex subunits from different modules in the transcriptional response of Arabidopsis thaliana to abiotic stress

Adverse environmental conditions are detrimental to plant growth and development. Acclimation to abiotic stress conditions involves activation of signaling pathways which often results in changes in gene expression via networks of transcription factors (TFs). Mediator is a highly conserved co-regulator complex and an essential component of the transcriptional machinery in eukaryotes. Some Mediator subunits have been implicated in stress-responsive signaling pathways; however, much remains unknown regarding the role of plant Mediator in abiotic stress responses. Here, we use RNA-seq to analyze the transcriptional response of Arabidopsis thaliana to heat, cold and salt stress conditions. We identify a set of common abiotic stress regulons and describe the sequential and combinatorial nature of TFs involved in their transcriptional regulation. Furthermore, we identify stress-specific roles for the Mediator subunits MED9, MED16, MED18 and CDK8, and putative TFs connecting them to different stress signaling pathways. Our data also indicate different modes of action for subunits or modules of Mediator at the same gene loci, including a co-repressor function for MED16 prior to stress. These results illuminate a poorly understood but important player in the transcriptional response of plants to abiotic stress and identify target genes and mechanisms as a prelude to further biochemical characterization.

Electrochemically Generated KO2 as a Phase-Transfer Mediator for Na–O2 Batteries

Superoxide-based Na–O2 batteries have attracted much attention as promising alternatives to peroxide-based Li–O2 batteries because of their small polarization for oxygen evolution reactions. However, the limited solubility of their discharge product, NaO2, leads to the surface-confined mechanism at high current densities, resulting in the poor energy density of Na–O2 batteries. In this connection, a few protic phase-transfer catalysts, such as water and benzoic acid, have been examined to improve reversible capacity because they promote the solution-mediated mechanism. Herein, KO2, which is electrochemically generated from potassium trifluoromethanesulfonate dissolved in electrolytes during discharge, is introduced as a phase-transfer mediator for Na–O2 batteries. The reaction mechanism of Na–O2 batteries containing a KO2 mediator is clarified through ex situ XRD, cross-sectional SEM, and ICP analyses. KO2 plays the role of a phase-transfer mediator because the desolvation rate of KO2 is slower than that of NaO2. As a result, Na–O2 batteries with KO2 show the solution-mediated mechanism rather than the surface-confined mechanism, thus delivering a high reversible capacity of approximately 6 mAh cm–2. In addition, since KO2 is chemically and electrochemically more stable than previous protic phase-transfer mediators, Na–O2 cells with KO2 show stable cycle performance, such as negligible capacity fading over 25 cycles.

Хронічне запалення, асоційоване з ожирінням, цукровим діабетом 2-го типу та кардіоваскулярним ризиком, як мішень для терапевтичних втручань. Частина 2

Огляд літератури присвячено актуальній дослідницькій проблемі – хронічному запаленню, асоційованому з ожирінням, цукровим діабетом 2-го типу та кардіоваскулярним ризиком. Оскільки запалення виступає в ролі патологічного медіатору за цих коморбідних станів, робляться спроби вплинути на хронічний запальний процес за допомогою лікарських засобів для зниження ризику виникнення серцево-судинних захворювань атеросклеротичного генезу. Це пов’язано з патогенетичними сигнальними механізмами, що ініціюють і підтримують запалення, а також залучають його в розвиток інсулінорезистентності й атерогенез. Розглянуто способи фармакологічного втручання з безпосереднім впливом на запалення (саліцилати, низькодозове застосування метотрексату, біологічні препарати з протизапальною дією) та інші лікувальні заходи з протизапальним ефектом (антилейкотрієнова терапія) у контексті їхнього впливу на кардіометаболічний ризик.

The role of Mediator and Little Elongation Complex in transcription termination

Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to regulate the expression of certain genes. MED26 plays a role in recruiting SEC to protein-coding genes including c-myc and LEC to small nuclear RNA (snRNA) genes. However, how MED26 engages SEC or LEC to regulate distinct genes is unclear. Here, we provide evidence that MED26 recruits LEC to modulate transcription termination of non-polyadenylated transcripts including snRNAs and mRNAs encoding replication-dependent histone (RDH) at Cajal bodies. Our findings indicate that LEC recruited by MED26 promotes efficient transcription termination by Pol II through interaction with CBC-ARS2 and NELF/DSIF, and promotes 3′ end processing by enhancing recruitment of Integrator or Heat Labile Factor to snRNA or RDH genes, respectively.

Roles of Transparency and Trust in the Relationship between Privatization and Customers’ Satisfaction in Ethiopia: Results of Structural Equation Modelling

As a part of public sector reform, privatization has been actively experienced since three decades across the globe. This study examines the relationship between privatization of public organizations and customers’ satisfaction in Ethiopia with the mediating role of transparency and trust. The structural equation modelling was applied to 315 samples taken from privatized services and manufacturing sectors. The results established that transparency alone fails to be a mediator, but trust plays the role of a partial mediator into the relationship between privatization and customers satisfaction. Combined together, the model results into a partial mediation of both transparency and trust.

Exploring Nurses' Involvement in Artificial Nutrition and Hydration at the End of Life: A Scoping Review.

This review aimed to summarize existing nursing literature to provide an overview of the extent, range, and nature of nurses' involvement in artificial nutrition and hydration (ANH) at the end of life and to map the key concepts underpinning nurses' involvement in ANH. A scoping review was designed following the methodological framework guidelines of Arksey and O'Malley and the recommendations for advancing the methodology by Levac etal. An inductive qualitative content analysis was conducted according to the guidelines by Elo and Kyngäs. Thirty-nine articles were identified. Content analysis revealed 1 main category: "nurses' role in the decision-making process," with the 2 subcategories of "mediator" and "activator." The category and subcategories are influenced by the following generic categories: "being," "feeling," and "knowing," each of them constituted by 2 subcategories in their turn. Nurses perform the roles of activator and mediator. Their ability to establish good relationships and their attitudes enable the creation of teamwork and closeness to patients and family: relationships and attitudes are the subcategories of the "being" category. The category "feeling" represents the ways nurses experience the decision-making process, which can raise ethical and moral dilemmas and cause emotional responses. For these reasons, nurses have to create the right balance between personal-self and professional-self. The category "knowing" includes nurses' clinical and ethical knowledge about ANH. It emerges that deep clinical and ethical knowledge of ANH is necessary to provide consistent, adequate care at end of life.

Invasion of Herpes Simplex Virus 1 into Murine Dermis: Role of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors during Aging.

Skin is a major target tissue of herpes simplex virus 1 (HSV-1), and we are only beginning to understand how individual receptors contribute to the initiation of infection in tissue. We recently demonstrated the impact of the receptors nectin-1 and herpesvirus entry mediator (HVEM) for entry of HSV-1 into murine epidermis. Here, we focus on viral invasion into the dermis, a further critical target tissue in vivo In principle, murine dermal fibroblasts are highly susceptible to HSV-1, and we previously showed that nectin-1 and HVEM can act as alternative receptors. To characterize their contribution as receptors in dermal tissue, we established an ex vivo infection assay of murine dermis. Only after separation of the epidermis from the dermis, we observed single infected cells in the upper dermis from juvenile mice at 5 h postinfection with increasing numbers of infected cells at later times. While nectin-1-expressing cells were less frequently detected, we found HVEM expressed on most cells of juvenile dermis. The comparison of infection efficiency during aging revealed a strong delay in the onset of infection in the dermis from aged mice. This observation correlated with a decrease in nectin-1-expressing fibroblasts during aging while the number of HVEM-expressing cells remained stable. Accordingly, aged nectin-1-deficient dermis was less susceptible to HSV-1 than the dermis from control mice. Thus, we conclude that the reduced availability of nectin-1 in aged dermis is a key contributor to a decrease in infection efficiency during aging.IMPORTANCE HSV-1 is a prevalent human pathogen which invades skin and mucocutaneous linings. So far, the underlying mechanisms of how the virus invades tissue, reaches its receptors, and initiates infection are still unresolved. To unravel the mechanical prerequisites that limit or favor viral invasion into tissue, we need to understand the contribution of the receptors that are involved in viral internalization. Here, we investigated the invasion process into murine dermis with the focus on receptor availability and found that infection efficiency decreases in aging mice. Based on studies of the expression of the receptors nectin-1 and HVEM, we suggest that the decreasing number of nectin-1-expressing fibroblasts leads to a delayed onset of infection in the dermis from aged compared to juvenile mice. Our results imply that the level of infection efficiency in murine dermis is closely linked to the availability of the receptor nectin-1 and can change during aging.

Z-Scheme Photocatalytic Systems for Solar Water Splitting.

As the world decides on the next giant step for the renewable energy revolution, scientists have begun to reinforce their headlong dives into the exploitation of solar energy. Hitherto, numerous attempts are made to imitate the natural photosynthesis of plants by converting solar energy into chemical fuels which resembles the “Z‐scheme” process. A recreation of this system is witnessed in artificial Z‐scheme photocatalytic water splitting to generate hydrogen (H2). This work outlines the recent significant implication of the Z‐scheme system in photocatalytic water splitting, particularly in the role of electron mediator and the key factors that improve the photocatalytic performance. The Review begins with the fundamental rationales in Z‐scheme water splitting, followed by a survey on the development roadmap of three different generations of Z‐scheme system: 1) PS‐A/D‐PS (first generation), 2) PS‐C‐PS (second generation), and 3) PS‐PS (third generation). Focus is also placed on the scaling up of the “leaf‐to‐tree” challenge of Z‐scheme water splitting system, which is also known as Z‐scheme photocatalyst sheet. A detailed investigation of the Z‐scheme system for achieving H2 evolution from past to present accompanied with in‐depth discussion on the key challenges in the area of Z‐scheme photocatalytic water splitting are provided.

Victim no more: a temporal-causal analysis of how a mediator can help out a bullying victim

ABSTRACTBullying is an intentional abusive behaviour, caused by a power imbalance, which can leave long-lasting effects over the mental and physical health of a victim. In order to combat such situations, victims need someone that can help them, a mediator who is able to reduce the oppression. This paper presents temporal-causal network models related to victimization and its support, based upon social and cognitive literature. The aim of the study is to explore responses of a victim after being bullied and how a mediator can support a victim. Here, a ‘fight or fly strategy’ is presented along with the role of mediator in order to support a victim. Subsequently, the model is tuned and analysed with respect to derived empirical data. Lastly, simulation experiments are compared with a publically available dataset, to verify the behaviour of the model.

Effects of statherin on the biological properties of titanium metals subjected to different surface modification

The failure of dental implants is usually caused by bacteria infection, poor bioactivity and biocompatibility. It is a common phenomenon clinically. Statherin, a salivary protein, plays a crucial role of mediator between materials and cells/bacteria. However, the conformation of statherin might be changed by the implants in vivo. In this study, we investigated the effects of statherin on the bioactivities, antibacterial abilities and biocompatibilities of the titanium metals and the reaction mechanism. We found that the conformation of statherin was mainly influenced by surface composition, surface structure, surface roughness, surface hydrophilia and Ti−OH groups of materials. Statherin could decrease the cell biocompatibility of the titanium metals including pure titanium (PT), anodic oxidation (AO), sandblasting and etching (SLA) and plasma spraying hydroxyapatite (HA) coating in HGF cell experiments, regulate the bio-mineralization ability of HA coating in SBF, and enhance the antibacterial properties of PT and HA coating. This study revealed that surface properties of materials could change the conformation of statherin, which influenced the bioactivities, antibacterial properties and biocompatibilities of the materials in return.

Relationship Between Psychosocial Factors and Glucose Control in Adults With Type 2 Diabetes

ObjectivesDespite significant advances in medical therapy and unrestricted access to health care, >50% patients with type 2 diabetes (T2D) cannot maintain their blood glucose target levels. This cross-sectional study investigated the association between psychosocial behaviour and diabetes management in Newfoundland and Labrador, where the prevalence of T2D is the highest in Canada. MethodsData were collected from 165 adult T2D patients. Four sets of self-administered standardized questionnaires, a study-specific data form and electronic health records were utilized to obtain psychosocial information, patient characteristics and glycated hemoglobin (A1C) levels. ResultsThe group of participants with emotional burnout due to diabetes-related stress showed poor glycemic control (89.4%) compared to the group with low stress (55.6%). The group with higher stress appraised T2D negatively (correlation coefficient r=0.719, and p<0.01), and had a tendency to use emotion-oriented coping (r=0.542, p<0.01) and had a poor perception of autonomous supportiveness (r=−0.300, p<0.01). A path model showed that stress, appraisal and coping explained 7.4% of the variance in A1C. Appraisal plays the role of mediator and explained 5.8% of the variance in A1C. ConclusionsA high prevalence of poor glycemic control was found in participants with a body mass index of ≥35. Participants with higher stress had a negative appraisal of T2D. The highly stressed group tended to use emotion-oriented coping and have a poor perception of autonomous supportiveness.

Investigating the effects of customer-based brand equity on turnover intentions with mediating effect of customer citizenship behavior

This study addresses the issue of rising turnover intention in Pakistan’s aviation industry and provides a theoretical foundation for lowering the turnover intention with the help of consumer citizenship behavior (CCB) and consumer-based brand equity by using the S-O-R theory. The data is collected with the help of structured personally administered questions following the intercept approach. Three most frequently used international airports which are located at Lahore, Karachi and Peshawar are targeted for data collection and total of 388 Pakistani flyers who traveled to international destinations participate in the survey. In addition, this study uses SmartPLS 3.2.7 for data analysis with the help of a two-stage approach. The results state that CBBE had a significant effect on CCB and CCB had a significant impact on turnover intentions. Furthermore, CCB plays the role of an important mediator for the effect of customer based brand equity (CBBE) on turnover intention. These results enhance existing literature about lowering the turnover intention with the help of CCB and CBBE in aviation industry of Pakistan. The study also highlights that managers and practitioners should improve customer engagement for exhibiting CCB to reduce customer turnover intentions in the aviation industry.

ФРГ и кризис в Сирии: активный посредник или пассивный наблюдатель?

During the Cold War, the involvement of the Federal Republic of Germany into the settlement of regional conflicts was insignificant. The situation started to change after German reunification which lead to the increase in Germany’s role in the international arena. Political, diplomatic and economic instruments started to belong to the main features of German foreign policy in the region and created a positive image among the Arab countries. Today, at first sight, the Middle East does not belong to the top priorities of German foreign policy. However, in the foreign policy hierar¬chy, the region is among the top three after Europe and the United States, ahead of Asia, Africa and Latin America. Berlin’s increased focus on the Middle East is determined by a number of factors. Among them are German historical responsibility towards Jewish people and obligation to ensure Israel’s right to existence and security; dependence of the German economy on energy resources from the Arab countries; region’s proximity to Europe, and such arising threats as terrorism, illegal migration and regional conflicts. In its turn, regional conflicts are a unique opportunity for the Federal Republic of Germany to declare itself as an international mediator and to participate in peace processes on an equal footing with such world powers as the United States of America, Russian Federation or the People’s Republic of China. Maneuvering between the Arab countries and Israel, the United States and the European partners as well as explosive situation in the region lead to decreased efficiency of German policy towards the Arab countries. In such circumstances, is Berlin ready to assume the role of international mediator in this constantly sensitive region, or would it prefer to remain a passive observer? The analysis of Germany’s policy in the region in the context of the Syrian crisis will help to answer the above stated question.

The production of rice straw-derived biochar and its application for enhanced decolorization of azo dye as the role of redox mediator

The production of rice straw-derived biochar and its application for enhanced decolorization of azo dye as the role of redox mediator

Mildly regulated intrinsic faradaic layer at the oxide/water interface for improved photoelectrochemical performance.

Metal oxides are widely used in different fields, including photoelectrocatalysis, photocatalysis, dye-sensitized solar cells, photoinduced superhydrophilicity and so on. It is well-known that there are intrinsic hydrated layers on the surfaces of metal oxides in ambient air or the electrolyte. Generally, interface layers between metal oxides and solutions have significant effects on the performances in these applications. However, the exact roles of the intrinsic hydrated layers are still unclear. In this study, taking TiO2 and Fe2O3 as model materials, we propose a mild heat treatment to increase the hydroxyl concentration in the hydrated surface layers of the oxides, which improves their photoelectrochemical performance remarkably. Moreover, we find that the heat-regulated hydrated layer plays the role of a hole transfer mediator between oxides and the electrolyte, which can accelerate both interface charge collection and oxygen evolution reaction kinetics in acidic solution. The new insights into the intrinsic hydrated interface layer on oxides can offer guidance not only in photoelectrocatalysis, but also in the other applications mentioned above.