Changing Role Research Articles

Functional and Compositional Changes in Sirex noctilio Gut Microbiome in Different Habitats: Unraveling the Complexity of Invasive Adaptation.

The mutualistic symbiosis relationship between the gut microbiome and their insect hosts has attracted much scientific attention. The native woodwasp, Sirex nitobei, and the invasive European woodwasp, Sirex noctilio, are two pests that infest pines in northeastern China. Following its encounter with the native species, however, there is a lack of research on whether the gut microbiome of S. noctilio changed, what causes contributed to these alterations, and whether these changes were more conducive to invasive colonization. We used high-throughput and metatranscriptomic sequencing to investigate S. noctilio larval gut and frass from four sites where only S. noctilio and both two Sirex species and investigated the effects of environmental factors, biological interactions, and ecological processes on S. noctilio gut microbial community assembly. Amplicon sequencing of two Sirex species revealed differential patterns of bacterial and fungal composition and functional prediction. S. noctilio larval gut bacterial and fungal diversity was essentially higher in coexistence sites than in separate existence sites, and most of the larval gut bacterial and fungal community functional predictions were significantly different as well. Moreover, temperature and precipitation positively correlate with most of the highly abundant bacterial and fungal genera. Source-tracking analysis showed that S. noctilio larvae at coexistence sites remain dependent on adult gut transmission (vertical transmission) or recruitment to frass (horizontal transmission). Meanwhile, stochastic processes of drift and dispersal limitation also have important impacts on the assembly of S. noctilio larval gut microbiome, especially at coexistence sites. In summary, our results reveal the potential role of changes in S. noctilio larval gut microbiome in the successful colonization and better adaptation of the environment.

Impact of metabolic unhealthiness and its changes on the risk of erosive esophagitis: a cohort study.

We aimed to compare the risk of erosive esophagitis (EE) among individuals with different phenotypes based on metabolic health status and obesity and investigate the role of changes in metabolic health in EE risk. A cohort of 258 892 asymptomatic adults without EE at baseline who underwent ollow-up esophagogastroduodenoscopy (EGD) were categorized into the following four groups according to metabolic health and obesity status: (i) metabolically healthy (MH) non-obese; (ii) metabolically unhealthy (MU) non-obese; (iii) MH obese; and (iv) MU obese. EE was defined as the presence of grade A or higher mucosal breaks on EGD. During a median follow-up of 4.5years, the incidence rates of EE were 0.6/103 person-years (PY), 1.7/103 PY, 1.7/103 PY, and 3.1/103 PY in the MH non-obese, MU non-obese, MH obese, and MU obese groups, respectively. The multivariable-adjusted hazard ratio (HR) (95% confidence intervals [CI]) for developing EE comparing the MH obese, MU non-obese, and MU obese groups with the MH non-obese group were 1.49 (1.29-1.71), 1.56 (1.25-1.94), and 2.18 (1.90-2.49), respectively. The multivariable-adjusted HR (95% CI) comparing the progression of MH to MU, regression of MU to MH, and persistent MU with the persistent MH group were 1.39 (1.10-1.76), 1.39 (1.09-1.77), and 1.86 (1.56-2.21), respectively. The increased risk of EE among the persistent MU group was consistently observed in individuals without obesity or abdominal obesity. Metabolic unhealthiness and obesity were independent risk factors for the development of EE, suggesting that maintaining both normal weight and metabolic health may help reduce the risk of EE.

Unraveling the role of vaporization momentum in self-jumping dynamics of freezing supercooled droplets at reduced pressures

Supercooling of water complicates phase change dynamics, the understanding of which remains limited yet vital to energy-related and aerospace processes. Here, we investigate the freezing and jumping dynamics of supercooled water droplets on superhydrophobic surfaces, induced by a remarkable vaporization momentum, in a low-pressure environment. The vaporization momentum arises from the vaporization at droplet’s free surface, progressed and intensified by recalescence, subsequently inducing droplet compression and finally self-jumping. By incorporating liquid-gas-solid phase changes involving vaporization, freezing recalescence, and liquid-solid interactions, we resolve the vaporization momentum and droplet dynamics, revealing a size-scaled jumping velocity and a nucleation-governed jumping direction. A droplet-size-defined regime map is established, distinguishing the vaporization-momentum-dominated self-jumping from evaporative drying and overpressure-initiated levitation, all induced by depressurization and vaporization. Our findings illuminate the role of supercooling and low-pressure mediated phase change in shaping fluid transport dynamics, with implications for passive anti-icing, advanced cooling, and climate physics.

Associations between Parental Educational Attainment, Children's 24-h Behaviors and Children's Hyperactivity Behavior in the COVID-19 Pandemic.

Parental Educational Attainment and children's 24-h behaviors significantly influenced children's hyperactivity symptoms. This study aimed to examine the mediating role of children's 24-h behavior changes due to the COVID-19 pandemic between Parental Educational Attainment and children's hyperactivity index. It also aimed to investigate the associations between Children's Physical Activity, digital media use, sleep, and hyperactivity index between two clusters of Parental Educational Attainments. The goal was to provide targeted behavioral optimization recommendations for caregivers to reduce the risk of children's hyperactivity. The study was a collaborative extension of the International iPreschooler Surveillance Study Among Asians and otheRs project and the Chinese Children and Adolescent Sports Health Promotion Action Project. The Parent-Surveillance of Digital Media in Childhood Questionnaire® and the Abbreviated Rating Scales from the Conners Parent Symptom Questionnaire were used to measure Parental Educational Attainment, children's behavior changes during the COVID-19 pandemic, and hyperactivity indexes. A total of 11,190 parents of 6-to-12-year-old children completed the online surveys in mainland China. A structural equation model was established by using Smart-PLS, and the linear regression model, and isotemporal substitution models were established by using a Compositional Data Analysis package with R program to achieve the research objectives. Changes in children's 24-h behaviors due to the COVID-19 pandemic had a significant mediation effect on the negative associations between Parental Educational Attainment and children's hyperactivity index (β = 0.018, T = 4.521, p < 0.001) with a total effect (β = -0.046, T = 4.521, p < 0.001) and a direct effect (β = -0.064, T = 6.330, p < 0.001). Children's Digital Media use was significantly and negatively associated with hyperactivity index among all children. Reallocated time from digital media use to both sleep and physical activity decreased the hyperactivity index, and vice-versa. For parents without tertiary education (R2 = 0.09, p < 0.001), sleep was significantly and negatively associated with the hyperactivity index (βilr-CSL = -0.06, p < 0.001); for parents with tertiary education (R2 = 0.07, p < 0.001), physical activity was significantly and negatively associated with the hyperactivity index (βilr-CPA = -0.05, p < 0.001), and sleep was significantly and positively associated with the hyperactivity index (βilr-CSL = 0.03, p < 0.001). A significant increase in the hyperactivity index was detected when physical activity time was reallocated to sleep, with a significant decrease in the opposite direction. Parental Educational Attainment and children's 24-h behaviors directly influenced children's hyperactivity index. However, a purposeful and targeted optimization of children's 24-h behaviors-namely, physical activity, digital media use, and sleep-could assist parents with different educational attainments to reduce their children's hyperactivity index and mitigate the risk of hyperactivity.

Forever Conquered: The Changing Role of Vikings in Modern and Contemporary Anglo-American Culture

Ever since their disruption and subsequent invasion of the British Isles in the early Middle Ages, the Scandinavian raiders known as 'Vikings' have had a significant presence in English culture and its self-perceived past. Anglo-American popular culture has become the primary home of the subject in the centuries since, with the Vikings appearing as everything from lecherous, bloodthirsty pirates to proud Christian heroes in the media of the English West. A timeline of this evolution can be drawn between Victorian era England and modern-day America, with works such as Walter Scott's The Pirate, Richard Fleischer's formative The Vikings, John McTiernan's turn-of-the-century The 13th Warrior, and DreamWorks Animation's highly successful How to Train Your Dragon&amp;nbsp;presenting compelling examples of the conceptual transformation that the Viking image has undergone. The popularity of Vikings in media and the form in which they have been used also reflects the way that literary and visual symbols have contributed to the spread and impact of major sociocultural and political movements throughout this period. As a result, the study of the Vikings' presence in Victorian and post-Victorian popular media is also the study of the Vikings' importance in the Anglo-American zeitgeist, enabling us to see the degree to which differing national climates have both shaped and platformed the Viking image across the last two hundred years.

Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis, and cell differentiation.

T lymphocytes from visceral and subcutaneous white adipose tissues (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused on this subject. Claudin-1 (CLDN1) is a protein involved canonically in tight junctions and tissue paracellular permeability. We evaluated T-lymphocyte gene expression in vWAT and sWAT and in the whole adipose depots in human samples. A Clariom D-based transcriptomic analysis was performed on T lymphocytes magnetically separated from vWAT and sWAT from patients with obesity (Cohort 1; N = 11). Expression of candidate genes resulting from that analysis was determined in whole WAT from individuals with and without obesity (Cohort 2; patients with obesity: N = 13; patients without obesity: N = 14). We observed transcriptional differences between T lymphocytes from sWAT compared with vWAT. Specifically, CLDN1 expression was found to be dramatically induced in vWAT T cells relative to those isolated from sWAT in patients with obesity. CLDN1 was also induced in obesity in vWAT and its expression correlates with genes involved in inflammation, fibrosis, and adipogenesis. These results suggest that CLDN1 is a novel marker induced in obesity and differentially expressed in T lymphocytes infiltrated in human vWAT as compared with sWAT. This protein may have a crucial role in the crosstalk between T lymphocytes and other adipose tissue cells and may contribute to inflammation, fibrosis, and alter homeostasis and promote metabolic disease in obesity.

Multiscale Study on the Intramolecular C-S Bond Formation Catalyzed by P450 Monooxygenase CxnD Involved in the Biosynthesis of Chuangxinmycin: The Critical Roles of Noncrystal Water Molecule and Conformational Change.

Cytochrome P450 monooxygenase CxnD catalyzes intramolecular C-S bond formation in the biosynthesis of chuangxinmycin, which is representative of the synthesis of sulfur-containing natural heterocyclic compounds. The intramolecular cyclization usually requires the activation of two reaction sites and a large conformational change; thus, illuminating its detailed reaction mechanism remains challengeable. Here, the reaction pathway of CxnD-catalyzed C-S bond formation was clarified by a series of calculations, including Gaussian accelerated molecular dynamics simulations and quantum mechanical-molecular mechanical calculations. Our results revealed that the C-S formation follows a diradical coupling mechanism. CxnD first employs Cpd I to abstract the hydrogen atom from the imino group of the indole ring, and then, the resulted Cpd II further extracts another hydrogen atom from the thiol group of the side chain to afford a diradical intermediate, in which a noncrystal water molecule entering into the active site after the formation of Cpd I was proved to play an indispensable role. Moreover, the diradical intermediate cannot directly perform the coupling reaction. It should first undergo a series of conformational changes leading to the proximity of two reaction sites. It is the flexibility of the active site of the enzyme and the side chain of the substrate that makes the diradical coupling to be successful.

Revisiting phase change: Ontogenetic and physiological ageing in vegetative propagation

For centuries, stem cuttings harvested from sexually mature trees have been recognized to be more difficult to root than those from juvenile shoots. This has been poorly understood and attributed to a combination of ontogenetic and physiological ageing. The recent suggestion that micro-RNA may play a key role in phase change has stimulated a re-examination of some old data that identified pre-severance light x nutrient interactions affecting the rooting ability of stem cuttings. This was linked to vigorous growth and active photosynthesis without constraint from accumulated starch. Support for the prime importance of physiological factors was also obtained when seeking to induce physiological youth in the crowns of ontogenetically mature trees by the induction of roots within the tree crown. Meanwhile, at the other end of the phase change spectrum, floral initiation occurred when the opposite set of environmental conditions prevailed so that growth was stunted, and carbohydrates accumulated in leaves and stems. A re-examination of this literature suggests that rooting ability is driven at the level of an individual leaf and internode emerging from the terminal bud affecting both morphological and physiological activity. In contrast, flowering occurs when internode elongation and assimilate mobilization were hindered. It is therefore suggested that the concepts of juvenility and ageing are not relevant to vegetative propagation and should instead be replaced by physiological and morphological ‘fitness’ to root.

Exploring the Responses of Teak and Eucalyptus to Elevated Carbon Dioxide in a Changing Atmosphere

Global warming plays a major role in climate change that is mainly caused by the increase of atmospheric carbon dioxide (CO2) and other greenhouse gases (GHGs) such as Methane (CH4), Nitrous oxide(N2O) and Chloro Fluoro Carbons (CFC) level in the last two decades. These greenhouse gases partially absorb long wave radiation remitted by the earth’s warm surface and re-emit the same resulting in warming up in the atmosphere. Climate change can be identified by changes in mean and variability of its properties. Climate changes are operated by the increase of (Green House gases) of them Carbon dioxide (CO2) is one of the most important greenhouse gases because of which influence the growth and morphology of industrially important tree species in tropics. Teak and Eucalyptus are the economically important tree species grown throughout the world in current study found that morphological, physiological and biochemical changes under elevated CO2 conditions. Forests, comprising diverse ecosystems and housing a plethora of plant species, play a critical role in mitigating climate change by acting as carbon sinks. Among the key contributors to this dynamic, Teak and Eucalyptus, as prominent tropical tree species, have been identified for their potential to sequester carbon dioxide (CO2) and influence ecosystem dynamics. Understanding how these trees respond to elevated CO2 levels is imperative for predicting the resilience and adaptability of forest ecosystems in the face of ongoing climate change. As we navigate a changing climate, unraveling the intricacies of how these vital tree species interact with elevated CO2 provides crucial insights for informed forest management and conservation practices.

What is the role of activism in air pollution politics? Understanding policy change in Poland

There has been growing awareness across the world of the negative health effects of air pollution. Poland is the European country that is worst affected by this problem, and the Polish government has in recent years adopted a number of measures designed to reduce coal use. This paper explores the role of civil society activism in this shift, investigating the extent to which local activists played a catalytic role in shaping popular awareness of air pollution and accounting for policy developments in this area. We draw on individual-level data from two Eurobarometer surveys together with qualitative data from a series of original elite interviews and the analysis of related policy documents, and we find little evidence that activism was a driver of variations in local popular awareness of air pollution, but support for the supposition that activism played a major role in shaping policy change at local level.

Photochromic Perovskite Nanocrystals for Ultraviolet Dosimetry.

Excessive ultraviolet (UV) radiation has serious damage to human's health, therefore the development of visible, portable, and wearable sensor for monitoring UV radiation, especially the cumulative UV dosage, is highly desired but full of challenges. Herein, a wearable and flexible UV dosimeter based on photochromic perovskite nanocrystals (PNCs) is designed. The obtained CsPbCl3 PNCs dispersed in dibromomethane (PNCs-DBM) undergo continuous, vivid, and multiple (from very weak purple to blue, cyan, and finally strong green) color change in response to UV radiation. It is demonstrated that the UV-induced degradation of DBM and subsequent anion-exchange reaction between CsPbCl3 and Br-, play a crucial role in the color change of PNCs-DBM. The properties of continuous fluorescence color change and enhanced fluorescence intensity enable the construction of sensitive and visible UV dosimeter. Furthermore, by integrated photochromic PNCs with flexible bracelet or PDMS substrate, a wearable UV sensor or a multi-indicator array for the detection of solar UV dosage is developed. This work may advance the fundamental understanding about photochromic perovskite, and show promising application of perovskite nanomaterials in easily fabricated, low-cost, visualized, and wearable solar UV dosimeter.

The biocultural heritage and changing role of indigenous yams in the Republic of Guinea, West Africa

Societal impact statementGlobal yam production is centred on West Africa, but there are significant knowledge gaps about farm‐level diversity across much of the region, and especially in Guinea. Although yam production is increasing in Guinea, in the longer term, varietal diversity and the sustainability of agri‐systems are at risk. Documentation of local crop diversity is essential as a baseline to understand trajectories of past and future varietal loss. This study utilises interdisciplinary approaches, which are needed to help understand the ways historic crop diversity is created and maintained within indigenous agricultural and food heritage systems, as well as the reasons for its loss over time.Summary Yams are important staple foods in many tropical and sub‐Saharan countries. The ‘yam belt’ extends from Guinea to western central Africa. However, yam cultivation is comparatively little researched or documented in Guinea, and the country is commonly not included within descriptions of key yam growing areas in Africa. Our study utilises ethnobotanic methods and plant specimen collections to fill these gaps in West African yam research. Interviews with over 70 farmers from six villages across the Kankan region of Guinea provide information on yam cultivation and diversity, and changes in living memory over the past 40 years. We present the analyses of ethnobotanical data from Haute‐Guinée on yam cuisine, and commercialisation, and on changes to the range of varieties grown over time. The annual cycle of indigenous yam agri‐systems remains a key part of rural life, food systems and economy. However, interviews revealed dramatic temporal changes over the last 40 years. Although yam production has increased, a narrow range of commercial cultivars is currently displacing the historically‐rooted local diversity. The expansion of yam cultivation is regarded locally as having relied on a shift to more unsustainable and extensive land use, and with herbicides and chemical fertilisers replacing intensive organic soil management. This has implications for research and development in sub‐Saharan agriculture for yams and other important native West African crops in the future.

Coping with marsh floods and fires: Resilience at the pile‐dwelling site of Dispilio, Northwestern Greece

AbstractLacustrine environments are considered favorable locations for Neolithic settlements, constituting a reliable year‐round water resource, which contributes to fertile arable land, rich biodiversity, and natural protection. Living by the wetlands, however, is characterized by intensive ecological vulnerabilities, that is, floods and fire events. These recurrent episodes are difficult to trace in the occupation layers since natural processes combined with human activities can form variable mixed microenvironments. Consequently, the direct impact of these events on the biography of the settlement and the decision‐making of its inhabitants is understudied. This paper presents a high‐resolution, microstratigraphic analysis at the Neolithic pile‐dwelling settlement of Dispilio (Kastoria, northern Greece) to trace past ecological threats and unravel the resilience strategies of the lake‐dwellers against the continuously altered microenvironments. By correlating the results with regional environmental and cultural events, this paper questions the role of environmental changes as triggers for cultural modifications and considers a wide range of strategies for coping with wetland hazards.

Local Communities Implications’ in Managing Woody Species and Carbon Accumulation in Sahelian parts of Maradi Region, Niger Republic

In Sahel, climate change will intensify especially in West Africa in the future and seasons are observed to have a decrease in rainfall projected. This situation will affect future woody vegetation cover because Sahelian zone was characterized by significant vegetation response to rainfall. Notwithstanding climate change impacts on woody vegetation cover, some human practices can play positive role in Sahelian vegetation change. This study aimed to analyze local community implications’ in managing woody species and carbon accumulation in Sahelian parts of Maradi Region, Niger Republic. Both quantitative and qualitative data were used in this study. Results showed that ecosystem services (provisioning, regulating and supporting) provided by woody trees species in the study area represent the main reasons for maintenance and protection of trees in farmlands. This clearly highlighted the roles of local communities in maintenance and protection of woody trees and consequently carbon accumulation by these woody species. This can allow farmers to be eligible to receive payments for the ‘’Carbon’’ that those practices contribute to sequester under a ‘’Carbon’’ trading arrangement in the Clean Development Mechanism (CDM) of the Kyoto Protocol of United Nations Framework Convention on Climate Change.

Research output and economic growth in technological laggard contexts: a longitudinal analysis (1980–2019) by type of research

The literature on the impact of research output (RO) on economic growth (EG) has been rapidly expanding. However, the single growth processes of technological laggard countries and the mediating roles of human capital (HC) and structural change have been overlooked. Based on cointegration analyses and Granger causality tests over 40 years (1980–2019) for Portugal, five results are worth highlighting: (1) in the short run, RO is critical to promote EG; (2) the long run relation between RO and EG is more complex, being positive and significant in the case of global and research fields that resemble capital goods (Life, Physical, Engineering & Technology, and Social Sciences), and negative in the case of research fields that resemble final goods (Clinical & Pre-Clinical Health, and Arts & Humanities); (3) existence of important short run mismatches between HC and scientific production, with the former mitigating the positive impact of the latter on EG; (4) in the long run, such mismatches are only apparent for ‘general’ HC (years of schooling of the population 25 + years), with the positive association between RO and EG being enhanced by increases in ‘specialized’ HC (number of R&D researchers); (5) structural change processes favouring industry amplify the positive (long-run) association and (short-run) impact of RO on EG. Such results robustly suggest that even in technologically laggard contexts, scientific production is critical for economic growth, especially when aligned with changes in sectoral composition that favour industry.

Increased Care Provision and Caregiver Wellbeing: Moderation by Changes in Social Network Care Provision.

Previous research links increased care provision to worse wellbeing among family and friend caregivers, both before and during the coronavirus disease 2019 (COVID-19) pandemic. We expand on this by incorporating data on caregivers' social networks and exploring the relationships between own and network changes in care during the pandemic and caregiver wellbeing. We use nationally representative data from 1,876 family and friend caregivers in the first wave of our Care Network Connections over Time study (fielded 12/17/2020-1/4/2021) who had provided care continuously since before the COVID-19 pandemic began. Caregivers were asked about the amount of care that they and each member of their social networks were providing at the time of the survey relative to before the pandemic. We use multivariate regression models to examine the associations between five caregiver wellbeing outcomes and changes in care, and explore the moderating role of networks' changes in care. Among caregivers who had provided care since prior to the pandemic, most increased (42.0%) or maintained the same (40.8%) care. Their networks also typically increased (33.4%) or maintained (46.5%) care. Increasing one's own care provision was associated with higher levels of anxiety, depression, loneliness, and emotional difficulty than maintaining stable care. Among those who increased care, these levels were highest when the network also increased or decreased care. Increased care provision was most strongly associated with poor caregiver wellbeing in contexts where caregivers' social networks also changed care provisions. Supports for caregivers undertaking additional care tasks should take into account caregivers' networks.

Retrieval of Surface Energy Fluxes Considering Vegetation Changes and Aerosol Effects

The exchange of moisture and energy between the land and the atmosphere plays a crucial role in terrestrial hydrological cycle and climate change. However, existing studies on the retrieval of surface water and heat flux tend to overlook the dynamic changes in surface vegetation and atmospheric aerosols, which directly affect surface energy and indirectly alter various meteorological factors, including cloud, precipitation, and temperature. In this study, we assess the machine-learning retrieval method for surface fluxes that takes into account vegetation changes and aerosol effects, using FLUXNET observations and remote sensing data to retrieve latent heat flux (LE) and sensible heat flux (H). We constructed four sets of deep neural network models: (a) The first set considers only meteorological factors, (b) the second set considers meteorological factors and aerosols, (c) the third set considers meteorological factors and vegetation changes, and (d) the fourth set comprehensively considers meteorological factors, aerosols, and vegetation changes. All model performances were evaluated using statistical indicators. ERA5 reanalysis and remote sensing data were used to drive the models and retrieve daily H and LE. The retrieved results were validated against ground observation sites that were not involved in model training or the FLUXCOM product. The results show that the model that considers meteorological factors, aerosols, and vegetation changes has the smallest errors and highest correlation for retrieving H and LE (RH = 0.85, RMSEH = 24.88; RLE = 0.88, RMSELE = 22.25). The ability of the four models varies under different vegetation types. In terms of seasons, the models that consider meteorological factors and vegetation changes, as well as those that comprehensively consider meteorological factors, aerosols, and vegetation changes, perform well in retrieving the surface fluxes. As for spatial distribution, when atmospheric aerosols are present in the region, the model that considers both meteorological factors and aerosols retrieves higher values of H compared to the model that considers only meteorological factors, while the LE values are relatively lower. The model that considers meteorological factors and vegetation changes, as well as the model that comprehensively considers meteorological factors, aerosols, and vegetation changes, retrieves lower values in most regions. Through the validation of independent observation sites and FLUXCOM products, we found that the model, considering meteorological factors, aerosols, and vegetation changes, was generally more accurate in the retrieval of surface fluxes. This study contributes to improving the retrieval and future prediction accuracy of surface fluxes in a changing environment.

Three-dimensional structure and transport flux of springtime smoke aerosols over the Indochina Peninsula

Springtime smoke aerosols attributable to biomass burning on the Indochina Peninsula (ICP) are a major source of absorbing aerosols globally, and play a nonnegligible perturbing role in climate change. Using smoke extinction profiles provided by the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) instrument, and aerosol and meteorological reanalyses for the period 2007–2021, this study investigated the three-dimensional structure and transport flux of springtime smoke aerosols over the ICP. Stratified analysis revealed that CALIOP-derived peaks of smoke aerosol optical depth (SAOD) and smoke mass flux (SMF) at altitudes of 0–2 km occur over the central ICP, which is the main source region. Driven by a southwesterly jet stream and updrafts, massive amounts of smoke aerosols are transported toward the northeast of the ICP, resulting in the largest stratified SAOD and SMF observed at altitudes of 2–4 km. Over the main smoke source regions, the estimated springtime SMF was approximately 0.4 Tg accumulated through a distance of 2° latitude at altitudes of 2–4 km. Meteorological analyses indicated a path for the transport of smoke aerosols to the mid-troposphere. Smoke aerosols in the source region are first lifted thermally to the 600-hPa level. Lifting then continues to the 500-hPa level via the combined effects of topography and frequent, deep, and dry convective updrafts over the mountainous areas of the northern ICP. The smoke aerosols are subsequently transported to South China and the western Pacific owing to strong westerly winds and weak vertical motion. Further analyses demonstrated that differences in meteorological conditions between daytime and nighttime have substantial impact on the vertical structure of smoke aerosols, particularly over the northeast of ICP. Compared to daytime, enhanced updrafts and moisture transport at night favor further lifting of smoke aerosols and greater extinction intensity owing to increased hygroscopic growth.

The Role of Immune Cells Driving Electropathology and Atrial Fibrillation.

Atrial fibrillation (AF) is the most common progressive cardiac arrhythmia worldwide and entails serious complications including stroke and heart failure. Despite decades of clinical research, the current treatment of AF is suboptimal. This is due to a lack of knowledge on the mechanistic root causes of AF. Prevailing theories indicate a key role for molecular and structural changes in driving electrical conduction abnormalities in the atria and as such triggering AF. Emerging evidence indicates the role of the altered atrial and systemic immune landscape in driving this so-called electropathology. Immune cells and immune markers play a central role in immune remodeling by exhibiting dual facets. While the activation and recruitment of immune cells contribute to maintaining atrial stability, the excessive activation and pronounced expression of immune markers can foster AF. This review delineates shifts in cardiac composition and the distribution of immune cells in the context of cardiac health and disease, especially AF. A comprehensive exploration of the functions of diverse immune cell types in AF and other cardiac diseases is essential to unravel the intricacies of immune remodeling. Usltimately, we delve into clinical evidence showcasing immune modifications in both the atrial and systemic domains among AF patients, aiming to elucidate immune markers for therapy and diagnostics.

Role of Industry 5.0 for driving sustainability in the manufacturing sector: an emerging research agenda

PurposeWith ever-increasing global concerns over environmental degradation and resource scarcity, the need for sustainable manufacturing (SM) practices has become paramount. Industry 5.0 (I5.0), the latest paradigm in the industrial revolution, emphasizes the integration of advanced technologies with human capabilities to achieve sustainable and socially responsible production systems. This paper aims to provide a comprehensive analysis of the role of I5.0 in enabling SM. Furthermore, the review discusses the integration of sustainable practices into the core of I5.0.Design/methodology/approachThe systematic literature review (SLR) method is adopted to: explore the understanding of I5.0 and SM; understand the role of I5.0 in addressing sustainability challenges, including resource optimization, waste reduction, energy efficiency and ethical considerations and propose a framework for effective implementation of the I5.0 concept in manufacturing enterprises.FindingsThe concept of I5.0 represents a progressive step forward from previous industrial revolutions, emphasizing the integration of advanced technologies with a focus on sustainability. I5.0 offers opportunities to optimize resource usage and minimize environmental impact. Through the integration of automation, artificial intelligence (AI) and big data analytics (BDA), manufacturers can enhance process efficiency, reduce waste and implement proactive sustainability measures. By embracing I5.0 and incorporating SM practices, industries can move towards a more resource-efficient, environmentally friendly and socially responsible manufacturing paradigm.Research limitations/implicationsThe findings presented in this article have several implications including the changing role of the workforce, skills requirements and the need for ethical considerations for SM, highlighting the need for interdisciplinary collaborations, policy support and stakeholder engagement to realize its full potential.Originality/valueThis article aims to stand on an unbiased assessment to ascertain the landscape occupied by the role of I5.0 in driving sustainability in the manufacturing sector. In addition, the proposed framework will serve as a basis for the effective implementation of I5.0 for SM.