Complex Role Research Articles

Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus.

Aggressive behavior is instinctively driven behavior that helps animals to survive and reproduce and is closely related to multiple behavioral and physiological processes. The dorsal raphe nucleus (DRN) is an evolutionarily conserved midbrain structure that regulates aggressive behavior by integrating diverse brain inputs. The DRN consists predominantly of serotonergic (5-HT:5-hydroxytryptamine) neurons and decreased 5-HT activity was classically thought to increase aggression. However, recent studies challenge this 5-HT deficiency model, revealing a more complex role for the DRN 5-HT system in aggression. Furthermore, emerging evidence has shown that non-5-HT populations in the DRN and specific neural circuits contribute to the escalation of aggressive behavior. This review argues that the DRN serves as a multifaceted modulator of aggression, acting not only via 5-HT but also via other neurotransmitters and neural pathways, as well as different subsets of 5-HT neurons. In addition, we discuss the contribution of DRN neurons in the behavioral and physiological aspects implicated in aggressive behavior, such as arousal, reward, and impulsivity, to further our understanding of DRN-mediated aggression modulation.

Which intellectual activities are related to cognitive reserve? Introduction and testing a three-dimensional model.

A common belief among people and some researchers is that keeping yourself mentally active may decrease the risk of dementia. Over the past years, despite widespread efforts to identify proxies for protecting cognitive reserve against age-related changes, it is still not clear what type of intellectual activity would be beneficial for cognitive reserve. To fill this gap, we propose a three-dimensional model of intellectual activity. According to this conceptual model, intellectual activities could be distinguished based on their locations in a three-dimensions space, including; (1) Activation:activevs.passive, (2) Novelty:novelvs. familiar, and (3) Productivity:productivevs.receptive. We assumed that the activities that are categorized as more active, novel, and productive could be considered as a cognitive reserve proxy. To test this hypothesis, a sample of 237 participants older than 50 years (Mage = 58.76 ± 6.66; 63.7% women) was recruited to take part in the study. Episodic, semantic and working memory were assessed with computerized battery tests (Sepidar) and a self-report questionnaire was used to assess intellectual activities. Activities were categorized in terms of; (1) passive, familiar, and receptive activities (radio/watching TV), (2) active,familiar, and receptive activities (solving crosswords), (3) active,novel, and receptive activities (reading), and (4) active,novel, and productive activities (writing). The results indicated that writing moderates the effect of age on episodic and semantic memory. Reading only moderates the effect of age on semantic memory, and radio/watching TV and solving crosswords do not play a role in moderation analysis. Our finding suggests that intellectual activities have different moderating effects on the relationships between age and memory performance. Individuals with high levels of participation in novel and productive activities over the life course are less likely to clinically demonstrate cognitive impairments. Our results support the potential benefit of the three-dimensional model to provide a better insight into the complex role of intellectual activities in cognitive reserve, particularly for older adults. Further research is needed to evaluate the efficacy and the benefits of the model.

Revealing Pathway Complexity and Helical Inversion in Supramolecular Assemblies Through Solvent-Induced Radical Disparities.

New insights are raised to interpret pathway complexity in the supramolecular assembly of chiral triarylamine tris-amide (TATA) monomer. In cosolvent systems, the monomer undergoes entirely different assembly processes depending on the chemical feature of the two solvents. Specifically, 1,2-dichloroethane (DCE) and methylcyclohexane (MCH) cosolvent trigger the cooperative growth of monomers with M helical arrangement, and hierarchical thin nanobelts are further formed. But in DCE and hexane (HE) combination, a different pathway occurs where monomers go through isodesmic growth to generate twisted nanofibers with P helical arrangement. Moreover, the two distinct assemblies exhibit opposite excited-state chirality. The driving force for both assemblies is the formation of intermolecular hydrogen bonds between amide moieties. However, the mechanistic investigation indicates that radical and neutral triarylamine species go through distinct assembly phases by changing solvent structures. The neutralization of radicals in MCH plays a critical role in pathway complexity, which significantly impacts the overall supramolecular assembly process, giving rise to inversed supramolecular helicity and distinct morphologies. This differentiation in pathways affected by radicals provides a new approach to manipulate chiral supramolecular assembly process by facile solvent-solute interactions.

Practicing acroyoga in the space of possibilities: Complexity profile as a heuristic device in sport and exercise research

ABSTRACT This article explores the application of complexity science in sports and exercise research, introducing Ashby’s law of requisite variety, Boisot’s and McKelvey’s law of requisite complexity, and Bar-Yam’s complexity profile. These frameworks emphasize the role of complexity in system functionality and shed light on the delicate balance between complexity and scale. Utilising acroyoga as a novel research context, an interpretivist study was conducted to delve into the activity’s complexity profile, revealing the intricate interplay between fostering creativity and maintaining essential regulations. Examining acroyoga practitioners’ and influencers’ perspectives through the complexity profile underscores the sport’s complexity over scale, offering diverse physical, cognitive, affective, and social benefits. However, the limited emphasis on scaling might confine acroyoga to the fringes, hindering widespread acceptance. This study demonstrates the complexity profile as a heuristic tool, challenging assumptions and encouraging innovative perspectives. Acroyoga serves as a compelling case study, highlighting the complexity-scale balance and paving the way for further exploration and sports-related policy formulation.

Removal of strontium by nanofiltration: Role of complexation and speciation of strontium with organic matter

Strontium (Sr) removal from water is required because excessive naturally occurring Sr exposure is hazardous to human health. Climate and seasonal changes cause water quality variations, in particular quality and quantity of organic matter (OM) and pH, and such variations affect Sr removal by nanofiltration (NF). The mechanisms for such variations are not clear and thus OM complexation and speciation require attention. Sr removal by NF was investigated with emphasis on the role of OM (type and concentration) and pH (2–12) on possible removal mechanisms, specifically size and/or charge exclusion as well as solute-solute interactions. The filtration results show that the addition of various OM (10 types) and an increase of OM concentration (2–100 mgC.L−1) increased Sr removal by 10-15%. The Sr-OM interaction was enhanced with increasing OM concentration, implying enhanced size exclusion via Sr-OM interaction as the main mechanism. Such interactions were quantified by asymmetric flow field-flow fractionation (FFFF) coupled with an inductively coupled plasma mass spectrometer (ICP-MS). Both extremely low and high pH increased Sr removal due to the enhanced charge exclusion and Sr-OM interactions. This work elucidated and verified the mechanism of OM and pH on Sr removal by NF membranes.

Habitat complexity influences neuron number in six species of Puerto Rican Anolis.

Elucidating the selective forces shaping the diversity of vertebrate brains continues to be a major area of inquiry, particularly as it relates to cognition. Historically brain evolution was interpreted through the lens of relative brain size; however, recent evidence has challenged this approach. Investigating neuroanatomy at a finer scale, such as neuron number, can provide new insights into the forces shaping brain evolution in the context of information processing capacity. Ecological factors, such as the complexity of a species' habitat, place demands on cognition that could shape neuroanatomy. In this study, we investigate the relationship between neuron number and habitat complexity in three brain regions across six closely related anole species from Puerto Rico. After controlling for brain mass, we found that the number of neurons increased with habitat complexity across species in the telencephalon and 'rest of the brain,' but not in the cerebellum. Our results demonstrate that habitat complexity has shaped neuroanatomy in the Puerto Rican anole radiation and provide further evidence of the role of habitat complexity in vertebrate brain evolution.

Rebels with Shackles: The Role and Representation of Claude Cahun in Surrealism Movement

The significant change of women role in surrealism movement has been noticed by many researchers. They argue that the female role is no longer considered as femme-enfant, muse or spouses and lovers (bodies of desires, and as irrational and inferior creatures), their roles have instead become multi-faceted. Claude Cahun displays the complex and multiple roles of a woman as a surreal artist. She has multiple identities (a transgender, hyper-femininity, an androgyne and a lesbian). Meanwhile, her role is not confined by gender contexts, but she goes further, and she realizes and challenges the shackles of the broader social contexts, like the oppression of minority groups, homophobia and political upheaval. By focusing on Cahun, this essay has analyzed three questions, including what restrictions these male counterparts placed on women in the surrealist group, how Cahun’s artwork rebels against the male-dominated surrealist movement, and how her work challenges broader social conventions on the role and representation of women. The essay thus contributes to understanding the significant value of the role and representation of women in surrealism. Meanwhile, they are of great significance in understanding the value and contribution of women to society, as the subjective and individual equal to men.

Carcass provisioning and intra-guild risk avoidance between two sympatric large carnivores

Apex carnivores that rely primarily on predation play a central but complex role within scavenging ecology by potentially suppressing intra-guild competitors, but also facilitating them by providing a reliable supply of carrion. We investigated the competitive relationship between sympatric wolves (Canis lupus) and wolverines (Gulo gulo) in Norway across three seasons. We deployed remote cameras at fresh wolf kills (n = 29) and built Bayesian generalized linear mixed models (GLMMs) to explore the use of fresh wolf-killed prey by sympatric wolves and wolverines. Our results showed that wolves facilitated wolverines by providing scavenging opportunities. Biomass available from wolf kills was influenced by seasonal wolf prey preference and group size. Wolverines visited 100% of wolf kills in fall and winter, whereas only 18% in summer. We found that in winter, wolverines visited wolf kills 3.6 and 6.7 times more often than single wolves and wolf groups revisited their kills, and spent 10 and 25 times as much time at carcasses compared to single wolves and groups of wolves. Thus, wolverines played an important role in the depletion of wolf-killed prey, with potential effects on the scavenging behavior of other guild members. Understanding how globally threatened top predators may function as key species in scavenging processes is important to conservation as this may have community-wide cascading effects and support important ecosystem functions and services.Significance statementLarge carnivores serve a central role within scavenging ecology through the suppression and facilitation of intraguild competitors. The wolf, as an apex obligate predator, can provide a reliable supply of carrion, that can serve as an important resource to facultative scavengers. However, while facultative behavior helps to mitigate the effects of limited prey for scavengers, it can also increase exposure to competition and intraguild predation. Across three seasons, we explored the use of fresh wolf-killed prey by sympatric wolves and wolverines. Our findings reveal that wolves facilitate wolverines by providing scavenging opportunities, where biomass available from kills is influenced by wolves’ prey preference and group size. Wolverines, like wolves, utilized kills heavily during winter, when increased access to food is important to wolverine reproductive rates. Wolverines exhibited caching behavior, possibly reducing exposure to interspecific competition, while serving an important role in the depletion of carrion biomass.

The Impact of Auditor Competence and Auditor Experience on Audit Judgement, Mediated by Task Complexity, within Public Accounting Firms in the City of Medan

Purpose: This research aims to investigate the intricate interplay between Auditor Competence and Auditor Experience, emphasizing their significant impact on Audit Judgment. The study also introduces Task Complexity as an intermediary variable, mediating the association between these competencies and judgment outcomes. Theoretical Framework: The research is grounded in a theoretical framework that highlights the relationships among Auditor Competence, Auditor Experience, Task Complexity, and Audit Judgment. This framework provides a conceptual basis for understanding how these variables interact and contribute to the overall audit process. Methods: Employing an associative methodological approach, the study utilizes primary data obtained through meticulously designed questionnaires. The participants consist of 173 auditors actively working in Public Accounting Firms (KAP) located in the urban expanse of Medan City. The sampling technique employed is saturated sampling to ensure a comprehensive representation of the population. Analytical pursuits involve a sequential tripartite process, including outer model analysis, inner model analysis, and hypothesis testing. Findings: The empirical analysis reveals several key insights. Firstly, Auditor Competence significantly influences Audit Judgment outcomes. Secondly, Auditor Competence has a substantive impact on Task Complexity. Thirdly, Auditor Experience significantly resonates with the tenets of Audit Judgment. Fourthly, Auditor Experience demonstrates meaningful correlations with Task Complexity. However, the relationship between Task Complexity and Audit Judgment is not statistically significant. Additionally, the intermediary effect of Task Complexity on the relationship between Auditor Competence and Audit Judgment lacks statistical substantiation. Lastly, the mediating role of Task Complexity in the association between Auditor Experience and Audit Judgment lacks empirical significance. Practical Implications: The study's findings hold practical implications for auditing practices. Firms can enhance Audit Judgment by focusing on improving Auditor Competence and strategically leveraging Auditor Experience. Understanding the nuanced relationship between these factors and Task Complexity can inform training programs and professional development initiatives within the auditing profession. Originality/Value: This research contributes to the field by offering nuanced insights into the relationships between Auditor Competence, Auditor Experience, Task Complexity, and Audit Judgment. The empirical findings provide a unique perspective, revealing both significant and non-significant associations, thereby contributing to a more comprehensive understanding of the factors influencing audit quality. This study's originality lies in its meticulous methodology and its potential to inform practical strategies for optimizing audit processes.

Reversible Hydrosulfide (HS-) Binding Using Exclusively C-H Hydrogen-Bonding Interactions in Imidazolium Hosts.

H2S is a physiologically important signaling molecule with complex roles in biology and exists primarily as HS- at physiological pH. Despite this anionic character, few investigations have focused on the molecular recognition and reversible binding of this important biological anion. Using a series of imidazole and imidazolium host molecules, we investigate the role of preorganization and charge on HS- binding. Using a macrocyclic bis-imidazolium receptor, we demonstrate the unexpected 2:1 host-guest binding of HS-, which was characterized both in solution and by X-ray crystallography. To the best of our knowledge, this is the first example of this binding stoichiometry for HS- binding. Moreover, the short C-H···S distances of 2.53, 2.54, 2.76, and 2.79 Å are well within the sum of the van der Waals radii of the interacting atoms, which is consistent with strong C-H···S interactions.

Fatal attractions that trigger inflammation and drive atherosclerotic disease.

Atherosclerosis is the salient, underlying cause of cardiovascular diseases, such as arrhythmia, coronary artery disease, cardiomyopathy, pulmonary embolism and myocardial infarction. In recent years, atherosclerosis pathophysiology has evolved from a lipid-based to an inflammation-centric ideology. This narrative review is comprised of review and original articles that were found through the PubMed search engine. The following search terms or amalgamation of terms were used: "cardiovascular disease," "atherosclerosis," "inflammation," "GRP78," "Hsp60," "oxidative low-density lipoproteins," "aldehyde dehydrogenase," "β2-glycoprotein," "lipoprotein lipase A," "human cytomegalovirus." "SARS-CoV-2," "chlamydia pneumonia," "autophagy," "thrombosis" and "therapeutics." Emerging evidence supports the concept that atherosclerosis is associated with the interaction between cell surface expression of stress response chaperones, including GRP78 and Hsp60, and their respective autoantibodies. Moreover, various other autoantigens and their autoantibodies have displayed a compelling connection with the development of atherosclerosis, including oxidative low-density lipoproteins, aldehyde dehydrogenase, β2-glycoprotein and lipoprotein lipase A. Atherosclerosis progression is also concurrent with viral and bacterial activators of various diseases. This narrative review will focus on the contributions of human cytomegalovirus as well as SARS-CoV-2 and chlamydia pneumonia in atherosclerosis development. Notably, the interaction of an autoantigen with their respective autoantibodies or the presence of a foreign antigen can enhance inflammation development, which leads to atherosclerotic lesion progression. We will highlight and discuss the complex role of the interaction between autoantigens and autoantibodies, and the presence of foreign antigens in the development of atherosclerotic lesions in relationship to pro-inflammatory responses.

China and Türkiye’s Strategic Cooperation in the 21st Century: A ‘Complex Role’ Prism

ABSTRACT China and Türkiye, the two pivotal states with global political, economic, and cultural influence, are located at the two ends of East Asia and West Asia, respectively. They are both rising, non-western, and authoritarian powers. Thus, they should have built a strategic partnership. However, unlike China’s comprehensive strategic partnerships with Algeria, Egypt, Saudi Arabia, Iran, and the UAE, the relations between China and Türkiye have been at a low level of strategic cooperation since 2010. To de-mystify the puzzle, this paper integrates agent, relations, and structure, puts forward a ‘complex role’ hypothesis, and argues that China and Türkiye have three layers of bilateral, regional, and global roles, and their role conceptions, expectations, and performances have divergent trajectories. The compatible, competitive, and conflicting roles between Beijing and Ankara constitute both dynamics and restraints of their partnership. The two sides perceive each other as a mix of economic partners, political competitors and security rivals. To foster bilateral relations in the new era, the two Republics should manage their role competition and conflict, and enhance role compatibility in bilateral ties and multi-lateral arenas through inter-institutional convergence and role adaptation.

Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors.

Modern microscopy has revealed that core nuclear functions, including transcription, replication, and heterochromatin formation, occur in spatially restricted clusters. Previous work from our lab has shown that subnuclear high-concentration clusters of transcription factors may play a role in regulating RNA synthesis in the early Drosophila embryo. A nearly ubiquitous feature of eukaryotic transcription factors is that they contain intrinsically disordered regions (IDRs) that often arise from low complexity amino acid sequences within the protein. It has been proposed that IDRs within transcription factors drive co-localization of transcriptional machinery and target genes into high-concentration clusters within nuclei. Here, we test that hypothesis directly, by conducting a broad survey of the subnuclear localization of IDRs derived from transcription factors. Using a novel algorithm to identify IDRs in the Drosophila proteome, we generated a library of IDRs from transcription factors expressed in the early Drosophila embryo. We used this library to perform a high-throughput imaging screen in Drosophila Schneider-2 (S2) cells. We found that while subnuclear clustering does not occur when the majority of IDRs are expressed alone, it is frequently seen in full-length transcription factors. These results are consistent in live Drosophila embryos, suggesting that IDRs are insufficient to drive the subnuclear clustering behavior of transcription factors. Furthermore, the clustering of transcription factors in living embryos was unaffected by the deletion of IDR sequences. Our results demonstrate that IDRs are unlikely to be the primary molecular drivers of the clustering observed during transcription, suggesting a more complex and nuanced role for these disordered protein sequences.

Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors

Modern microscopy has revealed that core nuclear functions, including transcription, replication, and heterochromatin formation, occur in spatially restricted clusters. Previous work from our lab has shown that subnuclear high-concentration clusters of transcription factors may play a role in regulating RNA synthesis in the early Drosophila embryo. A nearly ubiquitous feature of eukaryotic transcription factors is that they contain intrinsically disordered regions (IDRs) that often arise from low complexity amino acid sequences within the protein. It has been proposed that IDRs within transcription factors drive co-localization of transcriptional machinery and target genes into high-concentration clusters within nuclei. Here, we test that hypothesis directly, by conducting a broad survey of the subnuclear localization of IDRs derived from transcription factors. Using a novel algorithm to identify IDRs in the Drosophila proteome, we generated a library of IDRs from transcription factors expressed in the early Drosophila embryo. We used this library to perform a high-throughput imaging screen in Drosophila Schneider-2 (S2) cells. We found that while subnuclear clustering does not occur when the majority of IDRs are expressed alone, it is frequently seen in full-length transcription factors. These results are consistent in live Drosophila embryos, suggesting that IDRs are insufficient to drive the subnuclear clustering behavior of transcription factors. Furthermore, the clustering of transcription factors in living embryos was unaffected by the deletion of IDR sequences. Our results demonstrate that IDRs are unlikely to be the primary molecular drivers of the clustering observed during transcription, suggesting a more complex and nuanced role for these disordered protein sequences.

Short-Term Evaluation of Woodland Strawberry in Response to Melatonin Treatment under Low Light Environment

The cultivation of strawberries in controlled environments presents challenges related to environmental stressors, especially insufficient light. Melatonin, as a widely investigated plant growth regulator, was considered as a potential candidate to mitigate damage, and enhance photosynthesis stability. However, whether melatonin can improve photosynthesis under light deficiency in woodland strawberry (Fragaria vesca) remains elusive. In this study, we evaluated gas exchange parameters, Chlorophyll fluorescence parameters, photochemical efficiency, and the related genes’ expression levels to decipher the multifaceted impact of melatonin on photosynthesis. We found concentration-dependent effects of melatonin on photosynthetic parameters, with potential benefits at lower concentration and inhibitory effects at higher concentration. Notably, melatonin increased non-photochemical quenching (NPQ), a mechanism for dissipating excess light energy, while leaving photochemical quenching (qP) relatively stable. Further analysis showed that melatonin up-regulated key xanthophyll cycle-related genes (DHAR, VDE, and PsbS), indicating its involvement in energy dissipation processes. In conclusion, our study uncovered the dual and complex role of melatonin in the short-term response of photosynthesis in woodland strawberries under low-light conditions.

Silent Sites of Memory in Paule Marshall’s "The Chosen Place, The Timeless People"

As the title of the book suggests, The Chosen Place, The Timeless People (1969) is place-focused; it is indeed a narrative of place and its people. The main fictional setting is a fictive Caribbean island, which acts as an essential locale in the protagonists’ act of (re)memory and (com)memoration. An emotionally charged place, this apparently insignificant island acquires a majestic stature in the book; it is space and place, home and exile, paradise and purgatory, past and present, remembrance and forgetfulness. This paper focuses on specific sites which are emblematic of the island community, given the complex role they play in the restoration of memory and identity. Pierre Nora’s concept of lieux de mémoire will be used here with an understanding that, in a Caribbean setting, places record the monumentality of loss caused by colonialism and its aftermath. The cane field and Sugar’s bar are places where the past lives, bearing constant proof of terrifying colonial abuse. Other locales, however, mainly dwellings and gardens, will be identified and examined as a solution to the protagonists’ exile. The paper aims to demonstrate that all these locales are the essence of the island or, to paraphrase Derek Walcott, they are the genuine fresco, map-less, history-less yet quintessential for the ‘persistence of memory.’

Elucidating the roles of chemistry, compositional complexity, and short-range order in the dislocation energetics of body-centered-cubic concentrated solid solutions

Elucidating the roles of chemistry, compositional complexity, and short-range order in the dislocation energetics of body-centered-cubic concentrated solid solutions

What makes video‐based academic lectures difficult for language learners to comprehend? The role of multimodal complexity

AbstractBy taking a multidisciplinary, evidence‐based approach to modeling video difficulty, this study investigates the impact of multimodal complexity on language learners' self‐ratings of video difficulty, while simultaneously accounting for the effects of learner differences and video production styles. A set of 320 instructional videos from the corpus of second language video complexity were analyzed using sophisticated natural language processing and computer vision algorithms to extract and compute a wide range of multimodal complexity indices. The results of a linear mixed‐effects model demonstrated that pitch variation and academic spoken formulaic sequences helped to facilitate viewing comprehension, whereas infrequent words, image clutter, the number of visual objects, salient objects, visual texts, shots, and moving objects all impeded viewing comprehension. This study concludes by presenting a number of practical implications that can prove useful for English as a Foreign Language teachers and practitioners alongside a comprehensive agenda for future research in this area.

Multifunctional role of the diaphragm: biomechanical analysis and new perspectives

This study explores the complex role of the diaphragm, traditionally considered essential in respiratory physiology, expanding understanding of its multifunctionality. Beyond respiratory mechanics, the diaphragm contributes to postural stabilization, lumbar support, and regulation of intra-abdominal pressure (IAP). By analyzing the diaphragm's eccentric contraction, we introduce two innovative concepts: "Diaphragm Antagonist Muscles" (DAM) and "Centration". DAM represents an evolution of the abdominal belt concept, integrating the pelvic floor and lower posterior trunk muscles. This muscular synergy is vital for respiratory dynamics and functions such as posture and integrity of the musculoskeletal, pressure, and postural systems. Centration, proposed as a conscious modulation skill of IAP, activates a neurophysiological interaction between the diaphragm, lower posterior trunk muscles, and the pelvic floor, revealing new implications of the diaphragm in sports, health, and kinesiological contexts.

The role of lymphatic vessels in corneal fluid homeostasis and wound healing.

The cornea, essential for vision, is normally avascular, transparent, and immune-privileged. However, injuries or infections can break this privilege, allowing blood and lymphatic vessels to invade, potentially impairing vision and causing immune responses. This review explores the complex role of corneal lymphangiogenesis in health and diseases. Traditionally, the cornea was considered devoid of lymphatic vessels, a phenomenon known as "corneal (lymph)angiogenic privilege." Recent advances in molecular markers have enabled the discovery of lymphatic vessels in the cornea under certain conditions. Several molecules contribute to preserving both immune and lymphangiogenic privileges. Lymphangiogenesis, primarily driven by VEGF family members, can occur directly or indirectly through macrophage recruitment. Corneal injuries and diseases disrupt these privileges, reducing graft survival rates following transplantation. However, modulation of lymphangiogenesis offers potential interventions to promote graft survival and expedite corneal edema resolution.This review underscores the intricate interplay between lymphatic vessels, immune privilege, and corneal pathologies, highlighting innovative therapeutic possibilities. Future investigations should explore the modulation of lymphangiogenesis to enhance corneal health and transparency, as well as corneal graft survival, and this benefits patients with various corneal conditions.