Role Of Zinc Supplementation Research Articles

The Role of Zinc Supplementation in Alleviating Inflammatory Biomarkers in Patients Undergoing Hemodialysis: A Randomized Placebo Controlled, Crossover Trial

Background: Chronic kidney disease (CKD), which progresses to end-stage renal disease (ESRD) and requires maintenance hemodialysis (MHD), is a global health issue. Inflammation in MHD patients is associated with increased mortality and cardiovascular events. Zinc, essential for immune function and possessing anti-inflammatory properties, is frequently deficient in these patients and could potentially help mitigate inflammation. Objectives: This study aims to assess the impact of zinc supplementation on inflammatory biomarkers, specifically (CRP) and the neutrophil-to-lymphocyte ratio (NLR), in MHD patients. Methods: In a double-blind, randomized controlled crossover trial conducted at Labafinejad Hospital, Tehran, MHD patients with zinc deficiency were initially allocated to either a zinc supplementation group or a placebo group. After 30 days, the groups were crossed over, with patients initially receiving zinc now receiving a placebo and vice versa. The primary outcome was changes in serum zinc levels, while secondary outcomes focused on CRP and NLR levels. Results: Significant changes in serum zinc levels were observed in both groups from baseline to Month 2 (drug-placebo group: Mean change -15.9±10.33 µg/dL, P < 0.05; placebo-drug group: Mean change -14.70 ± 12.58 µg/dL, P < 0.05). A significant initial reduction in CRP levels at Month 1 (P = 0.045) was not sustained at Month 2 (P = 0.812). No statistically significant changes in NLR were noted. Improvements in quality of life, including reductions in muscle pain and skin dryness, were significant in the drug-placebo group (P < 0.05). Conclusions: Zinc supplementation in MHD patients significantly improved serum zinc levels and initially reduced CRP levels, highlighting its potential role in managing inflammation. Although the impact on NLR was not significant, overall patient outcomes and quality of life showed promising improvements.

Role of zinc supplementation in the treatment of children with culture-proven febrile urinary tract infection

Objectives: To compare the efficacy of zinc plus antibiotics versus antibiotics alone in the treatment of culture-proven febrile urinary tract infection in children Patients and methods: This randomized control trial was conducted at FFH, Rawalpindi. Children with culture proven UTI requiring IV antibiotics were enrolled in the study (n=70) divided in two groups. Group A was given zinc in addition to the antibiotic while group B received antibiotic only. The results of two groups were then compared or the difference in the clinical response. Results: In our study total 70 patients were enrolled, 35 patients in each group. Mean age was 7.69±2.5 years in group A and 8.3±2.2 years in group B. There were 62.9% males group A and 60% in group B, females were 37.1% in group A and 40% in group B. Mean duration of illness was 6.9±2.4 days in group A and 8±4.1 days in group B. Efficacy was 82.9% in group A and 57.1% in group B, p-value 0.019. Conclusion: There was early clinical recovery and significant reduction in the time of hospital stay in patients given zinc along with the antibiotic treatment. Keywords: Zinc, urinary tract infection, febrile UTI

Can Oral Zinc Supplementation Reduce Relapses in Childhood Steroid-Sensitive Nephrotic Syndrome? A Systematic Review.

Frequent relapses and steroid dependence are common treatment challenges of steroid-sensitive nephrotic syndrome (SSNS) in children. Acute respiratory infection (ARI) is the most frequently reported trigger of relapse. Given the role of zinc supplementation in preventing ARI, some studies show that this targeted intervention may reduce relapses in childhood SSNS. This systematic review aimed to determine if oral zinc supplementation can significantly reduce relapses in this disease. We searched the PubMed and Google Scholar electronic databases for interventional and observational analytical studies without limiting their year or language of publication. We selected studies with primary data that met our inclusion criteria, screened their titles and abstracts, and removed duplicates. We used a preconceived structured form to extract data items from selected studies and conducted a quality assessment of randomized controlled trials (RCTs) and non-randomized studies with the Cochrane collaboration tool and the Newcastle Ottawa Scale, respectively. We qualitatively synthesized the extracted data to validate the review's objective. Eight full-text articles were selected, comprising four RCTs and four observational analytical studies. Two of the RCTs had a high risk of bias in three parameters of the Cochrane collaboration tool, while three non-randomized studies had low methodological quality. A total of 621 pediatric patients with SSNS were investigated in the eight studies: six participants dropped out in one study. Three RCTs indicate that zinc supplementation may lead to sustained remission or reduction in relapse rate. Similarly, three observational analytical studies suggest a significant relationship between reduced serum zinc levels and disease severity. Despite the association of zinc deficiency with increased morbidity in SSNS and the reduction of relapse rates with zinc supplementation, there is no robust evidence to recommend its use as a therapeutic adjunct. We recommend more adequately-powered RCTs to strengthen the current evidence.

Role of zinc supplementation in school aged children suffering from common cold

Role of zinc supplementation in school aged children suffering from common cold

Role of Zinc Supplementation in Reducing Relapses in Steroid Sensitive Nephrotic Syndrome

Objective: To evaluate and compare the effectiveness of zinc and B-Complex supplementation to prevent the recurrence of nephrotic syndrome in the cases priory responsive to corticosteroid therapy. Methodology It is a randomized controlled trial conducted at OPD Pediatric medicine, Shaheed Zulfiqar Ali Bhutto University, PIMS Children Hospital Islamabad from October 3, 2016 to April 2, 2017. 192 patients (96 in each group) were included in the study after obtaining informed consent from parents or guardians taken before determining the population. Patients were randomly assigned to two groups (Group 1: Zinc and Group 2: B-Complex) to receive oral zinc sulphate (10 mg / day) or B-Complex using a random number table. The patients were followed up after 4 months. All data were collected by the researchers themselves in a structured form. Results: The age of 192 participants of the trial averaged 6.38±3.42 years of age ranging from 1-12 years. There were 88 (45.8%) men and 104 (54.2%) women cases. In group 1, there were 22 (22.9%) and in group 2, there were 47 (49%) cases that had been pardoned. The recurrence of nephrotic syndrome was significantly higher in group 1 than group 2 (p = <0.001). Conclusion: The findings of this study suggest that Zinc supplementation is more preferrable to B-Complex supplementation as the rate of continuous remission was higher in the zinc group, so in the future may be added to the treatment regimen to treat steroid-sensitive nephrotic syndrome.

Zinc deficiency and its association with treatment-related toxicity in children with cancer.

Nutritional deficiencies in children with cancer at time of diagnosis and during treatment may negatively affect disease outcome and increase treatment-related toxicity. Yet zinc, an essential nutrient important for supporting immune function and known for reducing diarrheal episodes, is rarely assessed in these children. Fifty children (1month to 18years) with recently diagnosed cancer were enrolled in this study. An age and gender matched control group (n=50) was also recruited. Plasma and urinary zinc, plasma copper, and C-reactive protein (CRP) levels were measured at baseline, 3, and 6months following diagnosis. A retrospective review of the toxicity profile was performed in the cohort of children with cancer for the first 4years after initial diagnosis. CRP and plasma copper (both acute-phase reactants) were elevated in patients with cancer compared to controls at baseline, both p<.03. Plasma zinc levels were not significantly different from controls at baseline, but decreased by 11% in the cancer group over 6months of treatment, 83.2±15.6 to 74.3±14.8μg/dl, p=.01. Plasma zinc dropped to deficient levels in 35% of cases over the initial 6months. Zinc deficiency at 6months was related to an increased incidence of severe diarrhea during 4years of follow-up, p<.001. Zinc deficiency is an underrecognized problem among patients undergoing treatment for cancer and is associated with severe diarrhea. Further studies are needed to evaluate causes for zinc deficiency, related effects, and a possible role for zinc supplementation.

The Role of Zinc Supplementation in The Lung Tissue Damage of Tuberculosis Rats

Infection by Mycobacterium tuberculosis (Mtb) is a chronic contagious disease with a high mortality rate in various parts of the world, especially in developing countries with high poverty rates. The objective of the present study was to examine the effects of zinc supplementation on the lung tissue damage of the male tuberculosis rats. This study was conducted based on true experimental design, using a post-test control group design. Peribronchiolitis was found to have a higher rank in (K0, K1, K2) groups compared to the Mtb group treated with the addition of Zinc supplements (P1, P2, P3). Zinc supplementation in this study shows that there is a reduction in lung organ damage and having a positive impact on increasing the perivasculitis and granuloma. Zinc supplementation by its optimal dose of 50 mg/kg.bb/day given as additional nutrition in Mtb rats.

Zinc supplementation combined with antidepressant drugs for treatment of patients with depression: a systematic review and meta-analysis.

Zinc is an essential trace mineral required for the function of brain and neural structures. The role of zinc supplementation in the prevention and treatment of depression has been suggested in clinical studies that reported a reduction in depressive symptoms. The aim of this review was to determine whether zinc supplementation vs placebo can prevent or improve depressive symptoms in children, adolescents, or adults. Five electronic databases were searched, and studies published until September 2019 were included without language restriction. Randomized, controlled, crossover trials that evaluated the effect of zinc supplementation vs a comparator for prevention or improvement of depressive symptoms in children, adolescents, or adults were eligible for inclusion. Two authors independently performed data extraction and risk-of-bias assessment. The initial search identified 12 322 studies, 5 of which were eligible for meta-analysis. The standardized mean difference (SMD) showed an average reduction of 0.36 point (95%CI, -0.67 to -0.04) in the intervention group compared with the placebo group. Forstudies in which the mean age of participants was ≥ 40years, the SMD was reduced by 0.61 point (95%CI, -1.12 to -0.09) in the intervention group vs the placebo group. The meta-analysis by sample size (< 60 individuals and ≥ 60 individuals) did not show an effect of zinc supplementation in reducing depressive symptoms (SMD -0.28; 95%CI, -0.67 to -0.10; and SMD -0.52; 95%CI, -1.10 to 0.06). Zinc supplementation may reduce depressive symptoms in individuals treated with antidepressant drugs for clinical depression. PROSPERO registration number CRD42018081691.

Zinc and Autophagy in Age-Related Macular Degeneration.

Zinc supplementation is reported to slow down the progression of age-related macular degeneration (AMD), but there is no general consensus on the beneficiary effect on zinc in AMD. As zinc can stimulate autophagy that is declined in AMD, it is rational to assume that it can slow down its progression. As melanosomes are the main reservoir of zinc in the retina, zinc may decrease the number of lipofuscin granules that are substrates for autophagy. The triad zinc–autophagy–AMD could explain some controversies associated with population studies on zinc supplementation in AMD as the effect of zinc on AMD may be modulated by genetic background. This aspect was not determined in many studies regarding zinc in AMD. Zinc deficiency induces several events associated with AMD pathogenesis, including increased oxidative stress, lipid peroxidation and the resulting lipofuscinogenesis. The latter requires autophagy, which is impaired. This is a vicious cycle-like reaction that may contribute to AMD progression. Promising results with zinc deficiency and supplementation in AMD patients and animal models, as well as emerging evidence of the importance of autophagy in AMD, are the rationale for future research on the role of autophagy in the role of zinc supplementation in AMD.

Role of zinc supplementation in school aged children suffering from common cold: A clinical trial

Role of zinc supplementation in school aged children suffering from common cold: A clinical trial

Role of Zinc Supplementation on Ischemia/Reperfusion Injury in Various Organs.

Ischemia-reperfusion (I/R) injury is a serious condition which is associated with myocardial infarction, stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease, and sleep apnea and can lead to high morbidity and mortality. Salts of zinc (Zn) are commonly used by humans and have protective effects against gastric, renal, hepatic, muscle, myocardial, or neuronal ischemic injury. The present review evaluates molecular mechanisms underlying the protective effects of Zn supplement against I/R injury. Data of this review have been collected from the scientific articles published in databases such as Science Direct, Scopus, PubMed, and Scientific Information Database from 1991 to 2019. Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes. Zn also increases phosphatidylinositol 3-kinase (PI3K)/Akt and glycogen synthase kinase-3β (GSK-3β) phosphorylation and preserves protein kinase C isoforms. It is suggested that Zn can be administered before elective surgeries for prevention of side effects of I/R injury.

The role of zinc supplementation on the metallothionein system in children with autism spectrum disorder.

The present research was carried out to elucidate the role of zinc (Zn) supplementation on the plasma concentration and gene expression, as well as the effects on cognitive-motor performance, in a cohort of children with autism spectrum disorder (ASD). The study was performed on a cohort of 30 pediatric subjects with ASD, encompassing an age range of 3-8years. The impact of Zn supplementation was investigated in 3months (or 12weeks) on the ASD children. Each daily dosage of Zn was calculated as being equal to the body weight in kg plus 15-20mg. The effect of Zn was also evaluated on the serum level of metallothionein 1 (MT-1A), and the severity of autism via scores on the Childhood Autism Rating Scale. The effect of Zn was investigated on the gene expression of MT1-A before and after Zn supplementation. The data of the present study showed an increase in cognitive-motor performance and an increased serum metallothionein concentration, as well as a significant lowering in the circulating serum levels of copper (Cu) following Zn supplementation. In the cohort of ASD patients, the genetic expression of MT-1 was higher after Zn therapy than before the treatment. In conclusion, Zn supplementation might be an important factor in the treatment of children with ASD.

The role of zinc supplementation for diarrhoea in children: a critical review

Background: Nearly 1.7 million children suffer from diarrhoea and around 760,000 die each year. The high prevalence of diarrhoea in the developing countries is closely related to lack of safe drinking water, inadequate sanitation and hygiene, and poor health and nutritional status. These environmental conditions facilitate the spread of infectious disease easily. The great morbidity and mortality of this preventable and treatable disease raise concern on how to save children from this fatal disease by improving management of diarrhoea. Several studies suggest that zinc deficiency contribute towards high morbidity and mortality in diarrhoea. Further, there is an area of uncertainty regarding how significant zinc supplementation will help to reduce the duration and severity of diarrhoea in children compared to the diarrhoea management without zinc?&#x0D; Objective: To critically analyse the current evidences of zinc supplementation in diarrhoea.&#x0D; Data Sources: Keywords searching through MEDLINE Ovid database and additional references from retrieved articles. Study Selection: Limited to randomized controlled trial(RCT) study design and systematic review studies which were conducted from 2006 to 2016. However, there is one prospective cohort study included as it is a follow-up of subjects who participated in the previous double-blind randomized placebo-controlled trial.&#x0D; Data Synthesis: This review involves a summary of 10 articles that have been appraised on their relevance in evaluating the role of zinc in reducing severity and duration of diarrhoea in children. Further, the literature found is synthesised through method used in the studies and the effectiveness of zinc therapy&#x0D; Conclusion: Zinc is relatively safe to be used and it can improve diarrhoea management especially in developing countries.&#x0D; Bangladesh Journal of Medical Science Vol.18(2) 2019 p.190-195

The Effects of Zinc Supplementation on Immune Response of Obese Children With Family History of Atopy

Introduction: Obesity is associated with low-grade chronic inflammation and disbalance between cytokine production of T helper1 and T helper2 cells. Zinc plays role in balancing immune response, has anti-oxidant and anti-inflammation activities; its deficiency also common in obesity. The role of zinc supplementation in children with obesity with risk of atopy needs to be elucidated.Materials and Method: We performed randomized controlled trial double-blind to investigate the effect of daily 15 mg zinc supplementation for 6 weeks in children aged 13 to 14 years old with obese who has family history of atopy. Subjects were divided into group of zinc supplementation and placebo, recruited from junior high schools from Semarang municipality, performed during periods from January to December 2013. Plasma zinc concentration, leptin, immunoglobulin-E (Ig-E), interferon-γ (IFN-γ), interleukin-4 (IL-4) were measured, also body weight, height and ISAAC questionnaire to recruit subjects with family history of atopy.Result: There were 36 subjects. The concentration of zinc serum, Ig-E, IFN-γ, and IL-4 of two groups before supplementation were not significantly different (p&gt;0.05). Zinc supplementation increase the mean level of zinc concentration on treatment group compare to placebo group (27.74+11.80 vs 3.47+2.55, p=0.000). The concentration of Ig-E, IFN-γ and IL-4 serum were decreased at treatment group (15.5+20.46 vs 20.02+38.02, p=0.613), (1.82+3.59 vs 0.911+3.51, p=0.174), and (4.76+6.49 vs 2.44+4.41, p=0.085) respectively. Conclusion: Zinc supplementation increased the level of zinc serum concentration of obese children and decreased the risk of atopy.

Taste disturbances - are there any effective treatments?

Data sourcesSeveral electronic databases were searched such as Cochrane Oral Health's Trials, Cochrane Library, Medline Ovid, CINAHL EBSCO and AMED Ovid and ongoing registered clinical trials in clinicaltrials.gov and in the World Health Organization International Clinical Trials Registry Platform. No restriction was placed on language and date of publication.Study selectionThe authors included randomised clinical trials (RCTs) and cross-over trials comparing any pharmacological intervention or any non-pharmacological agent with a control intervention.Data extraction and synthesisTwo pairs of review authors independently and in duplicate assessed the quality of trials and extracted data.ResultsThe review included ten trials (581 participants). Nine were included in the quantitative analysis. Three trials were assessed as having a low risk of bias, four at high risk of boas and three were assessed as unclear risk of bias. The studies included in the review were studies evaluating patients with taste disorders either idiopathic or resulting from zinc deficiency or chronic renal failure.Nine trials compared zinc supplements to placebo for patients with taste disorders. The participants in two trials were children and adolescents with respective mean ages of ten and 11.2 years and the other seven trials had adult participants. Out of these nine, two trials of very low quality assessed the patient-reported outcome for improvement in taste acuity using zinc supplements (risk ratio (RR) 1.40, 95% confidence interval (CI) 0.94 to 2.09.The meta-analyses of three trials classified as very low-quality evidence for taste acuity improvement in idiopathic and zinc-deficient taste disorder patients resulted in a standardised mean difference (SMD) = 0.44, (95% CI 0.23 to 0.65); 366 participants.One cross-over trial using the first half of the results for taste detection (mean difference (MD) 2.50, 95% CI 0.93 to 4.07; 14 participants, very low-quality evidence), and taste recognition (MD 3.00, 95% CI 0.66 to 5.34; 14 participants, very low-quality evidence). The authors performed a meta-analysis for taste acuity improvement using objective outcome (dichotomous data) in idiopathic and zinc-deficient taste disorder patients (RR 1.42, 95% CI 1.09 to 1.84; 292 participants, two trials, very low-quality evidence). Out of the nine trials using zinc supplementation, four reported adverse events like eczema, nausea, abdominal pain, diarrhoea, constipation, decrease in blood iron, increase in blood alkaline phosphatase and minor increase in blood triglycerides.One trial tested taste discrimination using acupuncture (MD 2.80, 95% CI -1.18 to 6.78; 37 participants, very low-quality evidence).No adverse events were reported in the acupuncture trial.ConclusionsThe authors found very low-quality evidence that was insufficient to conclude on the role of zinc supplements to improve taste acuity reported by patients and very low-quality evidence that zinc supplements improve taste acuity in patients with zinc deficiency/idiopathic taste disorders. They could not find any evidence to conclude the role of zinc supplements for improving taste discrimination, or any evidence addressing health-related quality of life due to taste disorders.Very low-quality evidence was found that is not sufficient to conclude on the role of acupuncture for improving taste discrimination in cases of idiopathic dysgeusia (distortion of taste) and hypogeusia (reduced ability to taste).The authors were unable to draw any conclusions regarding the superiority of zinc supplements or acupuncture as none of the trials compared these interventions.

KAP SURVEY ON USE OF ZINC SUPPLEMENTATION IN ACUTE PAEDIATRIC DIARRHEA AMONG YOUNG DOCTORS IN A TERTIARY CARE HOSPITAL

Background: Zinc given as a combination therapy to new formulation of ORS has become an efficient approach for the treatment of acute Paediatric diarrhoea. Objective of present study is to find the perception, use and awareness of zinc use in acute paediatric diarrhoea among young medical doctors.&#x0D; Subjects and Method: Present study is a descriptive prevalence study. Study population consisted of young doctors working in medical, Paediatric and surgery wards. Data was collected by administering a structured questionnaire to the study population. Questionnaire was constructed and was pre-tested by researchers.&#x0D; Results: Study population consisted of 158 young doctors working in a Tertiary Care Hospital. 78.5% of them were familiar with zinc supplementation. 60% of the study participants knew role of zinc in decreasing stool volume and 63.3% knew that it reduces the stool frequency. Around 50% were aware of the role that zinc played in intestinal water reabsorption, 47% of the doctors knew the role of zinc in re-epithelisation of the intestinal mucosa. 65.8% of the participants consented to WHO protocol of giving zinc in adjunct to ORS reduces hospital stay.&#x0D; Conclusion: Present study revealed that a large number of the doctors were familiar with role of zinc supplements in management of diarrhoea in young children.. But specified knowledge on role of zinc in controlling Paediatric diarrhoea was sub optimal.

PROTOCOL: Efficacy and effectiveness of micronutrient supplementation and fortification interventions on the health and nutritional status of children under-five in low and middle-income countries: a systematic review.

PROTOCOL: Efficacy and effectiveness of micronutrient supplementation and fortification interventions on the health and nutritional status of children under-five in low and middle-income countries: a systematic review.

Role of zinc supplementation in acute respiratory tract infections in children aged 2 to 60 months

Background: Zinc has a major role in improving immune function and decreasing morbidity in various infectious diseases like acute respiratory tract infections, diarrhoeal diseases etc. The objective of the study was to study the effect of zinc supplementation on clinical manifestations, progress of illness and duration of acute respiratory infections.Methods: A randomized double blind controlled study was conducted in the Paediatric ward of a tertiary care hospital in New Delhi in 50 children aged 2 to 60 months. Children with previous episodes of wheezing, severe malnutrition, congenital heart diseases, pneumonia, history of taking multiple micronutrient formulations or zinc for any intercurrent illnesses like diarrhoea in the previous month prior to admission and history of any known immuno-deficiency disease or on any immunosuppressive medications(steroids) or anti malignancy treatment were excluded. Both placebo (syrup base) and zinc syrup (20 mg/5 mL elemental zinc as zinc sulfate) were given orally for a period of 14 days to the respective groups. Statistical analysis used: Statistical Package for the Social Sciences (IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp.). Chi-square test was done for qualitative variables and t-test was used for quantitative variables. P&lt;0.05 was considered as statistically significant.Results: The mean age of zinc group was 22.77 months (SD - 5.74) and that of placebo group was 22.86 months (SD - 5.88) with a p value of 0.98 which was not statistically significant. There were no significant differences in the clinical features in the two groups before starting therapy or after treatment at 24, 48 and 72 hours (P&gt;0.05).Conclusions: Zinc supplementation during episode of ARI did not show any substantial benefit in reducing duration or morbidity in children aged 2-60 months.

Glyphosate, Chronic Toxicity on Male Reproductive Indices and The Role of Zinc Supplementation in Wistar Rats

1. Abstract Sixty-four adult male Wistar rats were used. They were randomized into eight (8) groups viz: Group I administered distilled water (2 ml/kg), group II, administered zinc (50 mg/kg), group IIIadministeredglyphosate (14.4 mg/kg), group IV,administered glyphosate (375 mg/kg), group V administered glyphosate (750 mg/kg), group VIpretreated with zinc (50 mg/kg) for an hour then glyphosate administered (14.4 mg/kg), group VII, pretreated with zinc (50 mg/kg) for an hour then glyphosate administered(375 mg/kg) and group VIII, pretreated with zinc (100 mg/kg) for an hour then glyphosate administered(750 mg/kg). The experiment lasted for 36 weeks. At the end, blood samples from four rats in each group were collected after chloroform anesthesia and used for serum hormonal assays and samples of testes were taken for seminal and sialic acid analyses. Semen characteristics showed relative decreases in sperm concentration, live sperm concentration, sperm motility, progressive sperm motility and significant decrease in normal sperm morphology. Sperm tail abnormality, dead sperm and non-motile sperm motility relatively increased and significant increases were recorded in abnormal sperm morphology and non-progressive sperm motility and variable changes were obtained in mid-piece abnormality; decreased sialic acid concentration was recorded. Relative decrease in serum testosterone and marginal increases in serum luteinizing and follicle stimulating hormone were recorded. Fat vacuoles in the seminiferous tubules, degeneration of the spermatogenic cells, abnormal spermatids were recorded. It was concluded that the changes sequel to chronic glyphosate exposure in male Westar rats in this study were ameliorated with zinc. 2. Keywords: Chronic; Glyphosate; Reproductive Indices;Zinc

Glyphosate, Chronic Toxicity on Male Reproductive Indices and The Role of Zinc Supplementation in Wistar Rats

Glyphosate, Chronic Toxicity on Male Reproductive Indices and The Role of Zinc Supplementation in Wistar Rats