Role Of Socioeconomic Position Research Articles

Comparing the Health Status of Immigrant and New Zealand-Born Older Adults in Aotearoa New Zealand: The Role of Socioeconomic Position.

The study investigated the health status of older migrants relative to their New Zealand-born peers. We adopted a holistic view of health (physical, mental, and social) and a structural approach to health disparities based on migrant status and socioeconomic position. Using case-control matching based on age, gender, and education, the health status of 357 older migrants and 357 New Zealand-born older adults was compared. Older migrants reported significantly poorer social health. Health inequities were patterned by socioeconomic status. Working class older migrants had significantly poorer physical, mental, and social health than their New Zealand-born peers. Inequities in social wellbeing persisted even at the upper end of the social gradient. Migrant background is an important social determinant of health in older age. The reduced social wellbeing of economically advantaged migrants highlights vulnerabilities regardless of socioeconomic position and the need for targeted social policies.

The Role of Socioeconomic Position in the Association Between Mental Disorders and Mortality

Studies are lacking summarizing how the association between mental disorders and mortality varies by socioeconomic position (SEP), particularly considering different aspects of SEP, specific types of mental disorders, and causes of death. To investigate the role of SEP in the association between mental disorders and mortality and the association between SEP and mortality among people with mental disorders. MEDLINE, Embase, PsycINFO, and Web of Science were searched from January 1, 1980, through April 3, 2023, and a snowball search of reference and citation lists was conducted. Inclusion criteria were observational studies estimating the associations between different types of mental disorders and mortality, stratified by SEP and between SEP and mortality in people with mental disorders. Pairs of reviewers independently extracted data using a predefined data extraction form and assessed the risk of bias using the adapted Newcastle-Ottawa scale. Graphical analyses of the dose-response associations and random-effects meta-analyses were performed. Heterogeneity was explored through meta-regressions and sensitivity analyses. All-cause and cause-specific mortality. Of 28 274 articles screened, 71 including more than 4 million people with mental disorders met the inclusion criteria (most of which were conducted in high-income countries). The relative associations between mental disorders and mortality were similar across SEP levels. Among people with mental disorders, belonging to the highest rather than the lowest SEP group was associated with lower all-cause mortality (pooled relative risk [RR], 0.79; 95% CI, 0.73-0.86) and mortality from natural causes (RR, 0.73; 95% CI, 0.62-0.85) and higher mortality from external causes (RR, 1.18; 95% CI, 0.99-1.41). Heterogeneity was high (I2 = 83% to 99%). Results from subgroup, sensitivity, and meta-regression analyses were consistent with those from the main analyses. Evidence on absolute scales, specific diagnoses, and specific causes of death was scarce. This study did not find a sufficient body of evidence that SEP moderated the relative association between mental disorders and mortality, but the underlying mortality rates may differ by SEP group, despite having scarcely been reported. This information gap, together with our findings related to SEP and a possible differential risk between natural and external causes of death in individuals with specific types of mental disorders, warrants further research.

Perceptions of a caring school climate and mental well-being: a one-way street? Results from a random intercept cross-lagged panel model

We investigated the between- and within-person longitudinal relationship between perceptions of a caring school climate and mental well-being, and the role of socioeconomic position (SEP) for these constructs among high school students in Norway (N = 1508; 60.7% girls). Using a random intercept cross-lagged panel model, we found positive concurrent associations between perceptions of a caring school climate and mental well-being at both between and within levels, and positive cross-lagged effects at the within-person level from mental well-being to later perceptions of a caring school climate across all time points. SEP was positively associated with mental well-being at time one, and at all time points with perceptions of a caring school climate. The findings suggest that mental well-being is a significant contributor to how Norwegian adolescents subsequently perceive their school context, and underscore the importance of school staff being particularly attentive toward students who struggle with mental health, as well as those with lower SEP.

The Association Between Pediatric COVID-19 Vaccination and Socioeconomic Position: Nested Case-Control Study From the Pedianet Veneto Cohort

The success of pediatric COVID-19 vaccination strongly depends on parents' willingness to vaccinate their children. To date, the role of socioeconomic position (SEP) in pediatric COVID-19 vaccination has not been thoroughly examined. We evaluated the association between COVID-19 vaccination and SEP in a large pediatric cohort. A case-control study design nested into a pediatric cohort of children born between 2007 and 2017, living in the Veneto Region and followed up to at least January 1, 2022, was adopted. Data on children were collected from the Pedianet database and linked with the regional COVID-19 registry. Each child vaccinated with at least one dose of any COVID-19 vaccine between July 1, 2021, and March 31, 2022, was matched by sex, year of birth, and family pediatrician to up to 5 unvaccinated children. Unvaccinated children with a positive outcome on the swab test within 180 days before the index date were excluded from the analyses. Children were geo-referenced to determine their area deprivation index (ADI)-a social and material deprivation measure calculated at the census block level and consisting of 5 socioeconomic items. The index was then categorized in quintiles based on the regional ADI level. The association between ADI quintiles and vaccination status was measured using conditioned logistic regression models to estimate odds ratios and the corresponding 95% CIs. Quantile-g-computation regression models were applied to develop a weighted combination of the individual items to estimate how much each component influenced the likelihood of vaccination. All analyses were stratified by age at vaccination (5-11 and 12-14 years). The study population consisted of 6475 vaccinated children, who were matched with 32,124 unvaccinated children. Increasing area deprivation was associated with a lower probability of being vaccinated, with approximately a linear dose-response relationship. Children in the highest deprivation quintile were 36% less likely to receive a COVID-19 vaccine than those with the lowest area deprivation (95% CI 0.59-0.70). The results were similar in the 2 age groups, with a slightly stronger association in 5-11-year-old children. When assessing the effects of the weighted combination of the individual items, a quintile increase was associated with a 17% decrease in the probability of being vaccinated (95% CI 0.80-0.86). The conditions that influenced the probability of vaccination the most were living on rent, being unemployed, and being born in single-parent families. This study has shown a significant reduction in the likelihood of receiving a COVID-19 vaccine among children living in areas characterized by a lower SEP. Findings were robust among multiple analyses and definitions of the deprivation index. These findings suggest that SEP plays an important role in vaccination coverage, emphasizing the need to promote targeted public health efforts to ensure global vaccine equity.

Socioeconomic position over the life course and impaired lung function of older adults in Central and Eastern Europe: the HAPIEE study

BackgroundSocial differences in lung functioning have been reported, but the role of socioeconomic position (SEP) at different stages of life is less well understood, particularly in Central and Eastern Europe....

Barriers to healthcare seeking, beliefs about ovarian cancer and the role of socio-economic position. A cross-sectional multilevel study in Dubai, a multicultural society.

Background: Studies have shown that public awareness of ovarian cancer is weak, and women are often diagnosed at late stages when treatment is difficult. This study aimed to determine the barriers for seeking early medical care and level of knowledge and awareness among women regarding ovarian cancer.Design and methods: A structured questionnaire was designed and adapted from the validated cancer awareness measure.Results: The recognition level of ovarian cancer symptoms among women in this study varied from 12-51%, and the most alarming ones, back pain, eating difficulties, and persistent abdominal pain, were missed by most of the surveyed women. The most recognized ovarian cancer risk factors were never being pregnant, having a history of infertility, and going through menopause, while the least recognized was having personal or family history of breast cancer. Non-UAE nationals women with higher educational levels had better knowledge of ovarian cancer compared to their peers.Conclusions:A change or implementation model is highly recommended in order to improve women’s awareness of ovarian cancer symptoms. Strengthening education among women with regards to risk factors, early symptoms, and the need to seek early medical help should help to increase ovarian cancer awareness and reduce a delay in the diagnosis. Significance for public health In the absence of effective screening, "appropriate clinical suspicion" of the signs and symptoms of the ovarian cancer is currently the best strategy to detect the disease. To reduce the diagnostic interval, several countries have implemented referral guidelines and organizational changes. Most of these guidelines suggest that individuals presenting with symptoms indicative of cancer (alarm symptoms) should be urgently referred to specialized investigative trajectories. However, many studies worldwide have shown that public awareness levels of ovarian cancer are poor, therefore women are often diagnosed at late stages when treatment is difficult. Our findings demonstrate that the overall level of recognition of risk factors and symptoms of ovarian cancer among women in the UAE is indeed low and within a critical level. Thus, strengthening education among women with regards to risk factors, early symptoms, and the need to seek early medical will be helpful in increasing ovarian cancer awareness and reducing the delay in diagnosis.

Association between race/color and incidence of hypertension in the ELSA-Brasil population: investigating the mediation of racial discrimination and socioeconomic position

ABSTRACT Objective To investigate the mediation effect of socioeconomic position and racial discrimination in the association between race/color and incidence of hypertension in 4-years follow up. Methods We included 8,370 participants of the Longitudinal Study of Adult Health (ELSA-Brasil). A latent variable was constructed to represent socioeconomic position (SEP). The perception of discrimination was measured through an adaptation of the Lifetime Major Events Scale; and hypertension was defined using standard criteria. We investigated Body Mass Index (BMI) due to its role in proximal risk for hypertension. To investigate the mediating role of SEP and racial discrimination, we used structural equation modeling. Results SEP had a direct and negative effect on HT incidence (HT incidence increased in worse SEP categories), while the effect of BMI on HT was direct and positive. We did not find significant direct effects of race/color and racial discrimination on HT. As for indirect effects, we observed associations between race/color and HT only through SEP mediation. Conclusion According to our results, race/color is indirectly related to HT incidence, mediated by SEP. Racial discrimination was not a mediator in the relationship between race/color and HT in the follow-up period.

The importance of socioeconomic position in smoking, cessation and environmental tobacco smoke exposure during pregnancy

Tobacco is still a leading cause of premature death and morbidity. Particular attention has been given to pregnant women due to the scientific evidence on the importance of early life exposures for disease onset later in life. The purpose of this study was to assess smoking prevalence, smoking cessation rate and environmental tobacco smoke (ETS) exposure, and the role of socioeconomic position (SEP) on these behaviors among pregnant women. Cross-sectional data of 619 pregnant women, aged between 18 and 46 years, from Porto Metropolitan Area, Portugal, on current smoking, ETS exposure and SEP indicators was collected, face-to-face, using a questionnaire filled in during a personal interview at the postpartum hospital stay. The smoking prevalence, and ETS exposure among non-smokers before pregnancy was 27.6% and 57.4%, respectively. 4.1% of the participants reported to have stopped smoking before pregnancy, whereas about 41% quitted along pregnancy, resulting in a smoking prevalence at birth of 14.6%. Exposure to ETS also decreased throughout pregnancy to 49.8% at birth. Lower educational level was significantly associated with both higher smoking prevalence and exposure to ETS and lower smoking cessation. This study demonstrates that smoking and ETS exposure during pregnancy remains high, and that there are still significant socioeconomic inequalities in smoking; thus tobacco-focused preventive interventions need to be reinforced.

Socio-economic disparities and returning to work following an injury

BackgroundTraumatic injury is one of the main reasons for temporary and permanent occupational disability.The objective of this study was to define the role of socio-economic position on post-injury occupational absenteeism.MethodsThis was a nationwide retrospective cohort study, based on linking The Israeli National Trauma Registry (INTR) and the National Insurance Institute (NII) databases.The study population included 44,740 injured workers (residents of Israel, aged 21–67, hospitalized between 2008 and 2013 and employed prior to injury as salaried workers). Logistic-regression models tested the probability of not returning to work (RTW).ResultsThe majority of the study population (61%) RTW within 1 month following the injury event. Income prior to injury was significantly associated with longer out of work stay, explaining 9% variance. A significant interaction (p value < 0.0001) was found between age and income on out of work stay more than 1 month, 1 year and 2 years. Logistic regression models of out of work stay were conducted separately for all age groups. Lower income was associated with greater chance for out of work stay for more than 1 month; and the gap between the lowest and highest income quartiles was greater among older workers (age 55+), where there was an elevenfold increase in probability of not RTW among casualties from the lowest vs. highest income quartile. In comparison to other population groups, Arabs were at greater odds of longer out of work stay following an injury. Among injured persons recognized by the NII as having occupational injuries, the odds for not RTW within a month, a year and 2 years were respectively 3.9, 2.5 and 2.2 times significantly greater in comparison to employees injured outside the workplace.ConclusionsThis study identified population groups with a high probability of not RTW following an injury requiring hospitalization. Intervention programs for injured employees should promote early rehabilitation and aim to shorten out of work stay. These programs should be ethnically adapted and focus on underprivileged and disadvantaged populations.

Socioeconomic and migration status as predictors of emergency caesarean section: a birth cohort study

BackgroundWomen with a migration background are reportedly at a higher risk of emergency caesarean section. There is evidence that this is due in part to suboptimal antenatal care use and quality of care. Despite the fact that migrant women and descendants of migrants are often at risk of socioeconomic disadvantage, there is, in comparison, scarce and incomplete evidence on the role of socioeconomic position as an independent risk factor for emergency caesarean delivery. We therefore investigate whether and how migration background and two markers of socioeconomic position affect the risk of an emergency caesarean section and whether they interact with each other.MethodsIn 2013–2016, we recruited women during the perinatal period in Bielefeld, Germany, collecting data on health and socioeconomic and migration background, as well as routine perinatal data. We studied associations between migration background (1st generation migrant, 2nd/3rd generation woman, no migration background), socioeconomic status (educational attainment and net monthly household income), and the outcome emergency caesarean section.ResultsOf the 881 participants, 21% (n = 185) had an emergency caesarean section. Analyses showed no association between having an emergency caesarean section and migration status or education. Women in the lowest (< 800€/month) and second lowest (between 800 and 1750€/month) income categories were more likely (aOR: 1.96, CI: 1.01–3.81; and aOR: 2.36, CI: 1.27–4.40, respectively) to undergo an emergency caesarean section than women in the higher income groups.ConclusionsMigration status and education did not explain heterogeneity in mode of birth. Having a low household income, however, increased the chances of emergency caesarean section and thereby contributed towards producing health disadvantages. Awareness of these findings and measures to correct these inequalities could help to improve the quality of obstetric care.

Migrant mortality differences in the 2000s in Belgium: interaction with gender and the role of socioeconomic position

BackgroundBelgium has a long history of migration. As the migrant population is ageing, it is crucial thoroughly to document their health. Many studies that have assessed this, observed a migrant mortality advantage. This study will extend the knowledge by probing into the interaction between migrant mortality and gender, and to assess the role of socioeconomic position indicators in this paradox.MethodsIndividually linked data of the 2001 Belgian Census, the National Register and death certificates for 2001–2011 were used. Migrant origin was based on both own and parents’ origin roots. We included native Belgians and migrants from the largest migrant groups aged 25 to 65 years. Absolute and relative mortality differences by migrant origin were calculated for the most common causes of death. Moreover, the Poisson models were adjusted for educational attainment, home ownership and employment status.ResultsWe observed a migrant mortality advantage for most causes of death and migrant groups, which was strongest among men. Adjusting for socioeconomic position generally increased the migrant mortality advantage, however with large differences by gender, migrant origin, socioeconomic position indicator and causes of death.ConclusionsAdjusting for socioeconomic position even accentuated the migrant mortality advantage although the impact varied by causes of death, migrant origin and gender. This highlights the importance of including multiple socioeconomic position indicators when studying mortality inequalities. Future studies should unravel morbidity patterns too since lower mortality not necessarily implies better health. The observed migrant mortality advantage suggests there is room for improvement. However, it is essential to organize preventative and curative healthcare that is equally accessible across social and cultural strata.

Socioeconomic inequalities in adult oral health across different ethnic groups in England

BackgroundEthnic inequalities in oral health among British adults remain largely unexplored. This study explored the role of socioeconomic position (SEP) in explaining ethnic inequalities in oral health; and the consistency of socioeconomic inequalities in oral health across ethnic groups.MethodsData from 45,599 adults, aged 16 years and over, who participated in the Health Survey for England were pooled across 5 years. The seven ethnic groups included were White British, Irish, Black Caribbean, Indian, Pakistani, Bangladeshi and Chinese. Edentulousness and toothache were the outcome measures. A composite measure of SEP was developed based on education, social class, income and economic activity using confirmatory factor analysis. Ethnic inequalities in oral health were assessed in logistic regression adjusting for sex, age, survey year and SEP.ResultsIndian (OR: 0.55, 95%CI: 0.40–0.76), Pakistani (0.56, 0.38–0.83), Bangladeshi (0.35, 0.23–0.52) and Chinese (0.41, 0.25–0.66) were less likely to be edentulous than White British after controlling for SEP. Irish (1.22, 1.06–1.39) and Caribbean (1.37, 1.19–1.58) were more likely and Bangladeshi (0.83, 0.69–0.99) were less likely to have toothache than White British after controlling for SEP. Socioeconomic inequalities in edentulousness were consistently found across almost all ethnic groups while socioeconomic inequalities in toothache were found among White British and Irish only.ConclusionThis study shows that the role of SEP in explaining ethnic inequalities in oral health depended on the outcome being investigated. Socioeconomic inequalities in oral health among minority ethnic groups did not consistently reflect the patterns found in White British.

The Role of Socioeconomic Position in Determining Tooth Loss in Elderly Costa Rican: Findings from the CRELES Cohort

Objective: Differences in health status between socioeconomic groups continue to challenge epidemiological research. To evaluate health inequalities in tooth loss, using indicators of socioeconomic position (education level, occupation and subjective economic situation), in a large representative sample of elderly Costa Ricans, can contribute to conceive better adapted public health interventions. Methods: Data are from the Costa Rican Longevity and Healthy Aging Study (CRELES Pre-1945), a longitudinal study of a nationally representative sample of elders. 2827 participants were included in the study using data from the first wave conducted in 2005, and analyzed cross-sectionally. The sample was imputed for missing data using a multiple imputation model. Tooth loss was self-reported and informed about the quantity of missing teeth. Information on participant’s socioeconomic factors was collected via a questionnaire, including three measures approaching socioeconomic position: education level, occupation and subjective economic situation. Additional variables were included in the multivariate analyses as potential confounders. Results: Tooth loss was found to be strongly socially patterned, using variables characterizing socioeconomic position, mainly education level, occupational status and subjective economic situation. Conclusions: To highlight how socioeconomic position relates to tooth loss, can allow a better understanding of the origins of the social gradient in oral health, to tackle the most common chronic diseases across the world.

Absolute rather than relative income is a better socioeconomic predictor of chronic obstructive pulmonary disease in Swedish adults

BackgroundWhile psychosocial theory claims that socioeconomic status (SES), acting through social comparisons, has an important influence on susceptibility to disease, materialistic theory says that socioeconomic position (SEP) and related access to material resources matter more. However, the relative role of SEP versus SES in chronic obstructive pulmonary disease (COPD) risk has still not been examined.MethodWe investigated the association between SES/SEP and COPD risk among 667 094 older adults, aged 55 to 60, residing in Sweden between 2006 and 2011. Absolute income in five groups by population quintiles depicted SEP and relative income expressed as quintile groups within each absolute income group represented SES. We performed sex-stratified logistic regression models to estimate odds ratios and the area under the receiver operator curve (AUC) to compare the discriminatory accuracy of SES and SEP in relation to COPD.ResultsEven though both absolute (SEP) and relative income (SES) were associated with COPD risk, only absolute income (SEP) presented a clear gradient, so the poorest had a three-fold higher COPD risk than the richest individuals. While the AUC for a model including only age was 0.54 and 0.55 when including relative income (SES), it increased to 0.65 when accounting for absolute income (SEP). SEP rather than SES demonstrated a consistent association with COPD.ConclusionsOur study supports the materialistic theory. Access to material resources seems more relevant to COPD risk than the consequences of low relative income.

How does the social "get under the gums"? The role of socio-economic position in the oral-systemic health link.

To evaluate the extent of association between systemic inflammation and periodontal disease in American adults, and to assess whether socio-economic position mediated this relationship. We used data from the National Health and Nutrition Examination Survey (NHANES IV) (2001-2010). Systemic inflammation was defined by individual and aggregate (cumulative inflammatory load) biomarkers (C-reactive protein, white blood cell counts, neutrophil counts, and neutrophil:lymphocyte ratio). Loss of attachment and bleeding on probing were used to define periodontal disease. Poverty:income ratio and education were indicators of socio-economic position. Covariates included age, sex, ethnicity, smoking, alcohol, and attendance for dental treatment. Univariate and multivariable logistic regressions were constructed to assess the relationships of interest. In a total of 2296 respondents, biomarkers of systemic inflammation and cumulative inflammatory load were significantly associated with periodontal disease after adjusting for age, sex, and behavioural factors. Socio-economic position attenuated the association between markers of systemic inflammation and periodontal disease in the fully adjusted model. Socio-economic position partly explains how systemic inflammation and periodontal disease are coupled, and may thus have a significant role in the mechanisms linking oral and non-oral health conditions. It is of critical importance that the social and living conditions are taken into account when considering prevention and treatment strategies for inflammatory diseases, given what appears to be their impactful effect on disease processes.

Cancer mortality by migrant background in Belgium during the 2000s: Patterns and social determinants

AimTo map and compare site-specific cancer mortality for Belgians and five of the largest immigrant groups in Belgium, and to look into the role of socio-economic position (SEP) and urbanisation. MethodsWe use linked Belgian census and register data for the period 2001–2011. Mortality from common cancer sites is studied for Belgians and individuals with a migrant background from Italy, France, the Netherlands, Morocco and Turkey aged 40 to 69. We use indirect standardisation and Poisson regression modelling, taking into account the effect of age, urbanisation and SEP. First- (FG) and second-generation (SG) immigrants are included. ResultsThere is marked diversity in cancer mortality levels by migrant background, with oft-lower levels for FG Moroccan and Turkish immigrants, and levels usually closer to those of Belgians for European immigrants. Small increases are commonly observed by generation, although less clearly so for stomach and liver cancer. SEP plays an important role in the patterning of cancer mortality by migrant background. ConclusionMigrant background is associated with differences in site-specific cancer mortality levels in Belgium. The observed role of SEP warrants special attention to the most vulnerable socio-economic groups.

Ethnic inequalities in periodontal disease among British adults.

To explore ethnic inequalities in periodontal disease among British adults, and the role of socioeconomic position (SEP) in those inequalities. We analysed data on 1925 adults aged 16-65years, from the East London Oral Health Inequality (ELOHI) Study, which included a random sample of adults living in an ethnically diverse and socially deprived area. Participants completed a questionnaire and were clinically examined for the number of teeth with periodontal pocket depth (PPD)≥4mm and loss of attachment (LOA)≥4mm. Ethnic inequalities in periodontal measures were assessed in negative binomial regression models before and after adjustment for demographic (gender and age groups) and SEP indicators (education and socioeconomic classification). Compared to White British, Pakistani, Indian, Bangladeshi and Asian Others had more teeth with PPD≥4mm whereas White East European, Black African and Bangladeshi had more teeth with LOA≥4mm, after adjustments for demographic and SEP measures. The association of ethnicity with periodontal disease was moderated by education, but not by socioeconomic classification. Stratified analysis showed that ethnic disparities in the two periodontal measures were limited to more educated groups. This study showed considerable ethnic disparities in periodontal disease between and within the major ethnic categories.

The role of socioeconomic position as an effect-modifier of the association between outdoor air pollution and children's asthma exacerbations: an equity-focused systematic review.

The role of socioeconomic position (SEP) as an effect modifier of the association between asthma exacerbations and outdoor air pollution remains unclear. To identify and summarize the evidence regarding SEP as an effect modifier of the association between asthma exacerbations and outdoor air pollution in children. We conducted searches in five electronic databases from January 1950 to June 2015 with no language restriction. Observational studies involving children, measuring any non-biological outdoor air pollutant exposure, resulting in any asthma-related health service use, and reporting measures of effect by individual or aggregated SEP measures were included. Ten studies met the inclusion criteria. Five studies reported on hospitalizations, three on emergency department visits, one on ambulatory visits, and one on repeat hospital visits. Six studies identified differential effects of the effect of air pollution on asthma outcomes by SEP with stronger effects for children with a low SEP level; however, the analysis of interaction between air pollutants and SEP was significant in one study of asthma hospitalizations only. The differential effect was reported using individual and aggregated SEP measures. This review reveals that there is weak evidence of SEP as an effect-modifier of the association between air pollution and children's asthma exacerbations. While stronger negative effects on asthma-related hospitalizations occur for children living in a lower SEP, the sample size of some of the original studies limited the statistical assessment of the modification effect.

The moderating role of socioeconomic position in the intake of vegetables and soft drinks

The moderating role of socioeconomic position in the intake of vegetables and soft drinks

Role of socioeconomic position in multiple sclerosis etiology.

Multiple sclerosis (MS) is a debilitating autoimmune disease with a prominent inflammatory component. There have been strides identifying genetic and environmental MS risk factors, though much of the disease risk remains unknown. Recent large observational studies suggest adverse socioeconomic position increases the risk for MS, however the mediating biological processes are not understood. We hypothesize a prominent role for stress response, both the autonomic nervous system and the hypothalamic-pituitary-adrenal axis, which become maladaptive under frequent or chronic stimulation resulting in a proinflammatory phenotype. Thus, adverse SEP and chronic stress may predispose individuals for MS.