Role Of Neurobiological Factors Research Articles

Medical anthropology and symbolic cure: from the placebo to cultures of meaningful healing

The perspectives of medical anthropology on symbolic cure are crucial for understanding placebo mechanisms on the medical agenda. However, while classic biomedical conceptions of the placebo discredited cultural factors as legitimate therapeutic tools, the anthropological critical approach confronted this perspective in the opposite way, rejecting the role of neurobiological factors, and using culture as a self-contained phenomenon. This manuscript is a review of the symbolic healing, stressing the importance of an integrated and interdisciplinary study of the placebo response, and the need to go beyond both biological and cultural reductionisms. Various perspectives from medical anthropology will be described, ranging from classical to multilevel perspectives that enable consideration of the placebo in its neurobiological, psychological and cultural dimensions.

Neurobiological Information and Consideration in Dutch Pre-trial Forensic Reports of Juvenile Criminal Offenders

The increasing scientific evidence about the role of neurobiological factors in criminal behavior may affect daily practice of forensic assessment of young criminal offenders. We therefore investigated whether Dutch forensic experts increasingly include neurobiological factors in their pre-trial forensic reports and how this information was used in forensic considerations and recommendations. We used a sample of 232 pre-trial forensic reports (2005–2015) of adolescent and young adult (12–25) offenders with information on acquired brain injury, neurological disorder and/or a genetic abnormality. Attention to these neurobiological factors in relation to forensic questions in our sample was low and did not increase over the years. In addition, even when forensic experts mentioned a relation between neurobiological information and the index offense, this information was often not considered in questions regarding future risk and risk management. Forensic experts should pay more attention to neurobiological risk factors in both their assessment and further considerations and recommendations.

Speech disorders in children: early diagnosis and treatment

The author considers causes, clinical variants and diagnostic principles of speech development in children. A role of neurobiological factors in the genesis of speech disorders and developmental dysphasia including early organic CNS lesions due to perinatal pathology and hereditary predisposition is described. Outcomes of dysphasia in children reached school-age are discussed. A screening method of the identification of speech delay in early childhood is presented. Early diagnosis and treatment of speech disorders in children are of great importance. Timely treatment with nootropics facilitates the correction of speech disorders.

ОТСТАВАНИЕ РАЗВИТИЯ РЕЧИ В ПРАКТИКЕ ПЕДИАТРА И ДЕТСКОГО НЕВРОЛОГА

The article describes the main clinical forms and causes of speech delay in children. It presents modern data on the role of neurobiological factors in the speech delay pathogenesis, including early organic damage to the central nervous system due to the pregnancy and childbirth pathology, as well as genetic mechanisms. For early and accurate diagnosis of speech disorders in children, you need to consider normal patterns of speech development. The article presents indicators of pre-speech and speech development in children and describes the screening method for determining the speech delay. The main areas of complex correction are speech therapy, psycho-pedagogical and psychotherapeutic assistance, as well as pharmaceutical treatment. The capabilities of drug therapy for dysphasia (alalia) are shown.

Capturing the essence of decision making should not be oversimplified

Bentley et al. propose a thought-provoking approach to the question of causal factors underlying human choice behavior. Their map model is interesting, but too simplified to capture the essence of decision making. They disregard, among other matters, qualitative differences between various subcategories of social influences, and the role of neurobiological factors engaged in interdependent individual and social decision-making processes.

EPA-1301 - Neurobiological factors in suicidal behavior in patients with depressive disorders

Introduction Suicide is a major cause of disability and mortality. Aims Examine the role of neurobiological factors of suicidal behavior, includingneyrotransmitternyh and neurohormonal systems, which include the metabolism ofbiogenic amines. Objectives 55patients aged 17 - 35 years of both sexes (58 men and 97 women) who havecommitted suicide Methods Clinicalexamination, biochemical and immunogenetical methods. Results Found thattheir violation and imbalance, namely increased concentrations of serotonin inthe blood (2,39 ± 0,24 mmol / l) reduction in plasma melatonin (0,71 ± 0,07 mmol / l) and decreasedexcretion rate adrenaline and noradrenaline at night (0,39 ± 0,06 and 1,21 ± 0,25 mmol / h) and daytime periods(1,66 ± 0,26and 4,56 ± 0,86 mmol/ h), creates neurohormonal background for the development of psychopathologicalconditions that lead to suicidal intentions and actions. Conclusions Patientswith specified neurobiological changes have been unable to get out of the longconflict through active variant of overcoming conflict and completed suicidalacts. According to the results of biomedical research, with to appropriatecorrection is differentiated use of natural biogenic stimulants herbalantidepressant that selectively affect the turnover of serotonin, melatonin, or drugs that stimulate the function of epiphysis.

Burnout

"Burnout syndrome" is now a common reason for medical excuses from work, and thus an important topic in health-related economics. Much research is still needed, however, to establish the scientific basis for this entity, the criteria by which it might be diagnosed and classified, and how it should be treated. A systematic review of this topic, previously published as an HTA report, is presented here together with a selective overview of pertinent literature. There currently exists neither an officially accepted definition nor a valid instrument for the differential diagnosis of burnout syndrome. Its manifestations are generally considered to lie along three dimensions: emotional exhaustion, depersonalization, and reduced performance ability and/or motivation. Most of the available studies on its epidemiology and differential diagnosis provide no more than a low level of evidence for their conclusions. There have been no controlled trials of treatments for burnout. High-quality controlled studies on burnout syndrome are lacking. A standardized and internationally accepted diagnostic instrument with a validated rating scale should be developed. There is also a need for epidemiological and health-economic studies on the prevalence, incidence, and cost of burnout. The etiology and pathogenesis of burnout should be studied with special regard to the possible role of neurobiological factors. Treatments for it should be studied systematically so that their effects can be judged at a high level of evidence. In view of the current lack of knowledge about what is called "burnout," the term should not be used as a medical diagnosis or as a basis for decisions regarding disability or other socioeconomic matters.

Functional neuroimaging in anorexia nervosa: A clinical approach

Aims To provide a review of the available literature about the functional neuroimaging of anorexia nervosa, and to summarize the possible role of neurobiological factors in its pathogenesis. Methods A systematic review of the literature was performed using PubMed and Medline electronic database (1950–September 2009). Eligible studies were restricted to those involving the main parameters of cerebral activity and functional neuroimaging techniques. Findings of the reviewed studies have been grouped on a diagnostic subtype basis, and their comparison has been interpreted in terms of concordance. Results We found a high level of concordance among available studies with regard to the presence of frontal, parietal and cingulate functional disturbances in both anorexia nervosa restricting and binge/purging subtypes. Concordance among studies conducted regardless of the anorexia nervosa subtypes suggests an alteration in temporal and parietal functions and striatal metabolism. Conclusions The most consistent alterations in anorexia nervosa cerebral activity seem to involve the dorsolateral prefrontal cortex, the inferior parietal lobule, the anterior cingulate cortex and the caudate nucleus. They may affect different neural systems such as the frontal visual system, the attention network, the arousal and emotional processing systems, the reward processing network, and the network for the body schema.