Role In Motivational Processes Research Articles

The interoceptive sensibility in middle childhood: the Italian validation of the Self-Awareness Questionnaire

ABSTRACT Interoception refers to the processing of internal bodily states and plays a critical role in motivational processes and behaviours. Instruments for assessing its subjective components (i.e., interoceptive sensibility) during childhood are crucially needed. Thus, in this study, we adapted and evaluated the psychometric properties of the Self-Awareness Questionnaire (SAQ) in a sample of Italian children. The SAQ language was revised, and 239 children, ranging in age from 7 to 13 years, completed the adapted questionnaire (SAQ-C). A two-factor solution (visceral and somatosensorial domains) with 24 items showed the best fit of the data. The reliability was good. Convergent validity was fair, and the results indicated good discriminant validity. Moreover, correlational and regression analyses showed that interoceptive sensibility, particularly that associated with visceral sensations, increased with age. Current findings provide preliminary evidence that the SAQ-C may be a reliable and valid tool for assessing interoceptive sensibility in middle childhood.

The Unity of Opposites: The Flux Between Impulsiveness and Compulsiveness Mediated by the Endocannabinoid System

Background: Impulsiveness and compulsiveness, though traditionally assumed to represent the opposite poles of a spectrum, have increasingly been understood to have common, rather than disparate, features. Objective: We investigated the influence of the ECS on the intricate interplay between impulsiveness and compulsiveness. Method: We conducted a search in PubMed, PsyhInfo, and Scopus by using the keywords compulsiveness, Obsessive-Compulsive Disorder (OCD), impulsiveness, Impulse Control Disorders (ICDs), addiction, ECS, serotonin, and dopamine. Results: The ECS is famous for its role in motivational processes and reward signaling, contributing to the hedonic effect elicited by pleasurable activities. Impulsiveness involves an inability to delay pleasure; compulsiveness, in contrast, is associated with a postponement of present pleasure due to an increased sense of menace. Impulsiveness and compulsiveness work together to result in addiction. The manipulation of the ECS through pharmacological or genetic methods is effective on the manifestations of OCD, ICDs, and impulsiveness. The ECS is distributed throughout the basal ganglia, prefrontal cortex, amygdala, and hippocampus and interacts with serotonergic, dopaminergic, noradrenergic, GABAergic, and glutamatergic neural circuits which are all involved in impulsive and compulsive symptomatology. The ECS or cannabinoids exhibit divergent effects depending on environmental conditions, dose, and duration of exposure. The endocannabinoids are retrograde messengers inhibiting the presynaptic neurons (causing a braking effect) and released “on demand”, generating a fine-tuning adjustment of the neural activity. Conclusion: How impulsiveness and compulsiveness, two apparently opposite traits, interoperate might be accounted for by the specific functions of the ECS.

Crossing hands behind your back reduces recall of manual action sentences and alters brain dynamics

The embodied meaning approach posits that understanding action-related language recruits motor processes in the brain. However, the functional impact of these motor processes on cognition has been questioned. The present study aims to provide new electrophysiological (EEG) evidence concerning the role of motor processes in the comprehension and memory of action language. Participants read lists of sentences including manual-action or attentional verbs, while keeping their hands either in front of them or crossing them behind their back. Results showed that posture impacted selectively the processing of manual action sentence, and not of attentional sentences, in three different ways: 1) EEG fronto-central beta rhythms, a signature of motor processes, were desynchronized while reading action sentences in the hands-in-front posture compared to the hands-behind posture. The estimated source was the posterior cingulate cortex, involved in proprioceptive regulation. 2) Recall of nouns associated with manual sentences decreased when learning occurred in the hands-behind posture. 3) ERPs analysis revealed that the initial posture at learning modulates neural processes during subsequent recall of manual sentences in the left superior frontal gyrus, which is related to motor processes. These results provide decisive evidence for the functional involvement of embodied simulations in the encoding and retrieval of action-related language.

Location, location, location: the organization and roles of potassium channels in mammalian motoneurons.

The spatial and temporal balance of spinal α-motoneuron (αMN) intrinsic membrane conductances underlies the neural output of the final common pathway for motor commands. Although the complete set and precise localization of αMN K+ channels and their respective outward conductances remain unsettled, important K+ channel subtypes have now been documented, including Kv1, Kv2, Kv7, TASK, HCN and SK isoforms. Unique kinetics and gating parameters allow these channels to differentially shape and/or modify αMN firing properties, and recent immunohistochemical localization of K+ -channel complexes reveals a framework in which their spatial distribution and/or focal clustering within different surface membrane compartments is highly tuned to their physiological function. Moreover, highly evolved regulatory mechanisms enable specific channels to operate over variable levels of αMN activity and contribute to either state-dependent enhancement or diminution of firing. While recent data suggest an additional, non-conducting role for clustered Kv2.1 channels in the formation of endoplasmic reticulum-plasma membrane junctions postsynaptic to C-bouton synapses, electrophysiological evidence demonstrates that conducting Kv2.1 channels effectively regulate αMN firing, especially during periods of high activity in which the cholinergic C-boutons are engaged. Intense αMN activity or cell injury rapidly disrupts the clustered organization of Kv2.1 channels in αMNs and further impacts their physiological role. Thus, αMN K+ channels play a critical regulatory role in motor processing and are potential therapeutic targets for diseases affecting αMN excitability and motor output, including amyotrophic lateral sclerosis.

Neural Selectivity for Visual Motion in Macaque Area V3A.

The processing of visual motion is conducted by dedicated pathways in the primate brain. These pathways originate with populations of direction-selective neurons in the primary visual cortex, which projects to dorsal structures like the middle temporal (MT) and medial superior temporal (MST) areas. Anatomical and imaging studies have suggested that area V3A might also be specialized for motion processing, but there have been very few studies of single-neuron direction selectivity in this area. We have therefore performed electrophysiological recordings from V3A neurons in two macaque monkeys (one male and one female) and measured responses to a large battery of motion stimuli that includes translation motion, as well as more complex optic flow patterns. For comparison, we simultaneously recorded the responses of MT neurons to the same stimuli. Surprisingly, we find that overall levels of direction selectivity are similar in V3A and MT and moreover that the population of V3A neurons exhibits somewhat greater selectivity for optic flow patterns. These results suggest that V3A should be considered as part of the motion processing machinery of the visual cortex, in both human and non-human primates.

The insula, a grey matter of tastes: a volumetric MRI study in dementia with Lewy bodies

BackgroundDespite the growing number of discoveries during the past decades about its functions, the insula remains a mysterious ‘island’. In addition to its involvement in basic functions such as gustation and interoception, the insular cortex is now considered a key region for integrated functions such as emotion/motivation processing, decision-making and self-consciousness. We hypothesized that this structure, standing at the crossroads of such functions, could ground personal tastes in general, beyond food preferences and aesthetic judgements. Given that dementia with Lewy bodies is characterized by a focal atrophy within the insular cortex from the early stages, this condition provides an opportunity to test such a hypothesis.MethodsWe developed a questionnaire to assess potential changes in personal tastes, submitted it to a cohort of 23 patients with early-stage dementia with Lewy bodies and compared their questionnaire results to those of 20 age-matched healthy controls. Furthermore, we performed a global and regional neuroimaging study to test for a potential correlation between the patients’ scores for changes in personal tastes and their insular cortex volumes.ResultsOur results indicate that the patients presented significant changes in personal tastes compared to the controls, in both food and non-food domains. Moreover, imaging analyses confirmed the involvement of the insular cortex atrophy in the changes in personal tastes using global analysis, and in both food and non-food domains using regional analysis.ConclusionsThese results bring new insights into the role of the insula as a ‘grey matter of tastes’, this structure supporting personal preferences in general, beyond the food domain. The insular cortex could be involved through its role in motivational processes by the representation of subjective awareness of bodily states during the phenomenological experience of stimulus appraisal. However, we also argue that it could support the abstract representations of personal tastes as self-concepts, acutely exemplifying embodied cognition. Finally, the questionnaire on changes in tastes could constitute an interesting tool to help early diagnosis of dementia with Lewy bodies and to assess insular dysfunction more generally.

Comparing Intersubject Correlation (ISC) Between Autism Spectrum Disorder and Typically Developed Groups to Better Understand Biological Motion Processing

In this study, we addressed significant neurological differences between autistic and typically developed individuals, specifically when processing biological motion, using Intersubject correlation (ISC) analysis methods. ISC is a tool used to analyze functional magnetic resonance imaging (fMRI) data acquired under naturalistic stimuli. Using ISC, it is possible to pinpoint common brain responses within a group of individuals as they react to a specific stimulus. ISC is also used to highlight the different brain responses two different groups might have while experiencing the same stimulus. In this experiment, we used two subject groups, one group of autism spectrum disorder (ASD) individuals and one typically developed (TD) group of individuals. The participants in each group watched a ninety second clip of romantic ballet. A short clip of ballet dance was chosen as the stimulus because it had been used in past studies to specify brain responses associated with biological motion processing. Using a standard subject-wise permutation statistical test in the ISC Toolbox for analysis, we computed ISC difference maps between the ASD and TD groups. The findings suggested that during biological motion processing, lateralization of brain responses between the two groups differed; TD individuals had greater ISC in the right hemisphere while ASD individuals had greater ISC in the left hemisphere. Greater ISC in typically developed individuals was concentrated in the culmen of the cerebellum which is responsible for kinesthesia and coordination of movement and is also a component of the mirror neuron network that allows individuals to anticipate movement. These results were consistent with data from prior research that found that TD groups share more synchronized brain responses in the cerebellum, which characterizes higher prediction and anticipation of biological movement in TD groups than ASD groups. ISC within the autistic group was found in the temporal gyrus, which plays a neurological role in motion processing and has been seen to be activated in past comparative studies.

Artifacts and affordances

What are the affordances of artifacts? One view is that the affordances of artifacts, just as the affordances of natural objects, pertain to possible ways in which they can be manipulated (e.g., a computer keyboard affords grasping). Another view maintains that, given that artifacts are sociocultural objects, their affordances pertain primarily to their culturally-derived function (e.g., a computer keyboard affords typing). Whereas some have tried to provide a unifying notion of affordance to capture both aspects, here I argue that they should be kept separate. In this paper, I introduce a distinction between standard affordances, which concern the function of artifacts, and ad-hoc affordances, which refer to how artifacts are manipulated. I then argue for the neuropsychological plausibility of such a distinction, linking it to the dissociation between function knowledge and manipulation knowledge. Finally, I defend the equal status of these forms of knowledge and, hence, of standard and ad-hoc affordances, and I show that this has some implications for the debate on the role of motor processes in the conceptual knowledge of artifacts.

On Neuropsychiatric Manifestations of Basal Ganglia Injury: A Report of Three Cases and Literature Review

The basal ganglia have been considered to primarily play a role in motor processing. A growing body of theoretical and clinical evidence shows that in addition to the motor functions the basal ganglia play a key role in perceptual and visual disturbances. This role may be evident in patients with basal ganglia pathology and subsequent manifestation of symptoms that include cognitive, perceptual, and affective disturbances. We present three cases with basal ganglia pathology that demonstrate affective and psychotic symptoms. Two of the cases presented with late onset psychotic disturbances suggesting likely neurological etiologies. The third case presented with treatment refractory psychosis and symptoms that are rare for a diagnosis of schizophrenia. The role of incidental bilateral basal ganglia calcifications in all the cases is discussed. A review of current literature highlighting various neuropsychiatric manifestations of basal ganglia pathologies in various patients with psychiatric symptoms is presented.

The role of motor processes in mental rotation: selective shaping of cognitive processing via specific sensorimotor experience

ABSTRACTThe involvement of motor processes in mental rotation is experience-dependent: different levels of expertise in sensorimotor interactions lead to different strategies in mental rotation. In the present study, wrestlers, gymnasts, and nonathletes physically rotated objects that were either light (wooden) or heavy (lead) but otherwise having the same sizes and shapes. They then performed a mental rotation task using photographs of these objects in which the material and therefore the weight was visible. I hypothesized that wrestlers would rely more heavily on experience-based sensorimotor strategies in performing mental rotation because during their athletic practice they not only manipulate external “objects” (i.e., their opponent) but also have to plan future actions taking into account past experience of these “objects” (for example their weight). All participants reported that lead objects were harder to physically rotate than wooden ones. However, only wrestlers mentally rotated lead objects more slowly than wooden ones—as they would if they were physically rotating them—suggesting the involvement of motor processes. These findings show that the involvement of motor processes in mental rotation depends on specific rather than mere sensorimotor experience.

Single Neuron Firing Rate Statistics in Motor Cortex During Execution and Observation of Movement.

Mirror neurons, which fire during both the execution and observation of movement, are believed to play an important role in motor processing and learning. However, much work still remains to understand the similarities and differences in how these neurons compute in the motor cortex during movement execution and observation. Here, we performed experiments where a monkey both executes and observes a center-out-and-back task within the same experimental session. By recording from putatively the same neural population, we were able to analyze and compare single neuron statistics between movement execution and observation. We found that a majority of neurons in the primary motor cortex (M1) and dorsal premotor cortex (PMd) have statistically different firing rate statistics between movement execution and observation. As a result of this difference, we then wondered if neurons during movement observation exhibited a similar characteristic to those during movement execution: changing of preferred directions as a function of movement speed. Interestingly, we found that while observed movement speed is encoded in the neural population, it only alters a small proportion of the neuron's firing rate statistics. These results suggest that neural populations in Ml and PMd process information related to movement differently between execution and observation.

Sensorimotor training alters action understanding

The discovery of ‘mirror’ neurons stimulated intense interest in the role of motor processes in social interaction. A popular assumption is that observation-related motor activation, exemplified by mirror neurons’ matching properties, evolved to subserve the ‘understanding’ of others’ actions. Alternatively, such motor activation may result from sensorimotor learning. Sensorimotor training alters observation-related motor activation, but studies demonstrating training-dependent changes in motor activation have not addressed the functional role of such activation. We therefore tested whether sensorimotor learning alters action understanding. Participants completed an action understanding task, judging the weight of boxes lifted by another person, before and after ‘counter-mirror’ sensorimotor training. During this training they lifted heavy boxes while observing light boxes being lifted, and vice-versa. Compared to a control group, this training significantly reduced participants’ action understanding ability. Performance on a duration judgement task was unaffected by training. These data suggest the ability to understand others’ actions results from sensorimotor learning.

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation

Obesity is primarily due to food intake in excess of the body’s energetic requirements, intake that is not only associated with hunger but also the incentive value of food. The 5-hydroxytryptamine 2C receptor (5-HT2CR) is a target for the treatment of human obesity. Mechanistically, 5-HT2CRs are positioned to influence both homeostatic feeding circuits within the hypothalamus and reward circuits within the ventral tegmental area (VTA). Here we investigated the role of 5-HT2CRs in incentive motivation using a mathematical model of progressive ratio (PR) responding in mice. We found that the 5-HT2CR agonist lorcaserin significantly reduced both ad libitum chow intake and PR responding for chocolate pellets and increased c-fos expression in VTA 5-HT2CR expressing γ-aminobutyric acid (GABA) neurons, but not 5-HT2CR expressing dopamine (DA) neurons. We next adopted a chemogenetic approach using a 5-HT2CRCRE line to clarify the function of subset of 5-HT2C receptor expressing VTA neurons in the modulation of appetite and food-motivated behavior. Activation of VTA 5-HT2C receptor expressing neurons significantly reduced ad libitum chow intake, operant responding for chocolate pellets, and the incentive value of food. In contrast, chemogenetic inhibition of VTA 5-HT2C receptor expressing neurons had no effect on the feeding behavior. These results indicate that activation of the subpopulation of 5-HT2CR neurons within the VTA is sufficient to significantly reduce homeostatic feeding and effort-based intake of palatable food, and that this subset has an inhibitory role in motivational processes. These findings are relevant to the treatment of obesity.

The role of implicit theories of intelligence and ability in predicting achievement for Indigenous (Aboriginal) Australian students

Although researchers have shown that Indigenous (Aboriginal) Australian students perform significantly lower in academic achievement than non-Indigenous students, investigations into the role of motivational processes have been limited. In the current study, we focus on implicit theories of intelligence and ability (or, “implicit beliefs”), which refer to students' beliefs about the malleability (i.e., incremental beliefs) or static nature (i.e., entity beliefs) of intelligence and ability. More precisely, we examine whether students' Indigenous status predicts implicit beliefs and whether both predict academic achievement. In particular, we seek to determine the extent to which implicit beliefs play a mediating role between Indigenous status and academic achievement. We examine implicit beliefs of intelligence and implicit beliefs of mathematics ability. Our sample of 174 high school students comprised n = 87 Indigenous Australian students from 20 schools in grades 7–9 (63% male) and n = 87 randomly drawn non-Indigenous students from the same schools. Path analysis demonstrated that Indigenous status negatively predicted incremental beliefs of intelligence and ability, and that incremental beliefs positively predicted academic achievement. Of note, there was no direct association between Indigenous status and academic achievement; instead the relationship between Indigenous status and achievement operated via implicit beliefs. Combined, the results extend research surrounding Indigenous students' achievement and suggest one possible avenue for intervention.

Other-self confusions in action memory: The role of motor processes

People can come to falsely remember performing actions that they have not actually performed. Common accounts of such false action memories have invoked source confusion from the overlap of sensory features but largely ignored the role of motor processes. We addressed this lacuna with a paradigm in which participants first perform (vs. do not perform) actions and then observe another person performing some of the non-performed actions. In this paradigm, observation of videos showing another’s actions can later induce false self-attributions of these actions, the observation-inflation effect. Contrary to a sensory-feature account but consistent with a motor-simulation account, we found the effect even with perceptually impoverished action videos in which the majority of sensory features is absent, but motion cues are preserved (Experiment 1). We then created conditions during action observation that should (vs. should not) impede motor simulation. As predicted we found that the effect of observation was reduced when participants executed movements that were incongruent (vs. congruent) with the observed actions (Experiment 2). We discuss the processes that can produce associations of self with observed others’ actions and later affect observers’ action memory.

Fifteen-month-old infants use velocity information to predict others’ action targets

In a world full of objects, predicting which object a person is going to grasp is not easy for an onlooker. Among other cues, the characteristics of a reaching movement might be informative for predicting its target, as approach movements are slower when more accuracy is required. The current study examined whether observers can predict the target of an action based on the movement velocity while the action is still unfolding, and if so, whether these predictions are likely the result of motor simulation. We investigated the role of motor processes for velocity-based predictions by studying participants who based on their age differed in motor experience with the task at hand, namely reaching. To that end, 9-, 12-, and 15-month-old infants and a group of adults participated in an eye-tracking experiment which assessed action prediction accuracy. Participants observed a hand repeatedly moving toward and pressing a button on a panel, one of which was small, the other one large. The velocity of the reaching hand was the central cue for predicting which button would be the target of the observed action as the velocity was lower when reaching for the small compared to the large button. Adults and 15-month-old infants made more frequent visual anticipations to the close button when it was the target than when it was not and were thus able to use the information in the speed of the approach movement for the prediction of the action target. The 9- and 12-month-olds, however, did not display this difference. After the eye-tracking experiment, infants’ ability to aim for and press buttons of different sizes was evaluated. Results showed that the 15-month-olds were more proficient than the 9- and 12-month-olds in performing the reaching actions. The developmental time line of velocity-based action predictions thus corresponds to the development of performing that motor act yourself. Taken together, these data suggest that motor simulation may underlie velocity-based predictions.

Visuotactile motion congruence enhances gamma-band activity in visual and somatosensory cortices

When touching and viewing a moving surface our visual and somatosensory systems receive congruent spatiotemporal input. Behavioral studies have shown that motion congruence facilitates interplay between visual and tactile stimuli, but the neural mechanisms underlying this interplay are not well understood. Neural oscillations play a role in motion processing and multisensory integration. They may also be crucial for visuotactile motion processing. In this electroencephalography study, we applied linear beamforming to examine the impact of visuotactile motion congruence on beta and gamma band activity (GBA) in visual and somatosensory cortices. Visual and tactile inputs comprised of gratings that moved either in the same or different directions. Participants performed a target detection task that was unrelated to motion congruence. While there were no effects in the beta band (13–21Hz), the power of GBA (50–80Hz) in visual and somatosensory cortices was larger for congruent compared with incongruent motion stimuli. This suggests enhanced bottom-up multisensory processing when visual and tactile gratings moved in the same direction. Supporting its behavioral relevance, GBA was correlated with shorter reaction times in the target detection task. We conclude that motion congruence plays an important role for the integrative processing of visuotactile stimuli in sensory cortices, as reflected by oscillatory responses in the gamma band.

Students’ achievement goals, emotion perception ability and affect and performance in the classroom: a multilevel examination

Performance at school is affected not only by students’ achievement goals but also by emotional exchanges among classmates and their teacher. In this study, we investigated relationships between students’ achievement goals and emotion perception ability and class affect and performance. Participants were 949 Greek adolescent students in 49 classes and their Greek language and mathematics teachers. Results from multilevel analyses indicated that students’ mastery-approach and performance-approach goals were positively related to positive affect whereas performance-avoidance goals were negatively related to positive affect. At class-level, relationships between achievement goals and affect were moderated by students’ emotion perception ability. These findings highlight the importance of emotion abilities and their role in motivational processes for class-level outcomes.

A directional tuning map of Drosophila elementary motion detectors

The extraction of directional motion information from changing retinal images is one of the earliest and most important processing steps in any visual system. In the fly optic lobe, two parallel processing streams have been anatomically described, leading from two first-order interneurons, L1 and L2, via T4 and T5 cells onto large, wide-field motion-sensitive interneurons of the lobula plate. Therefore, T4 and T5 cells are thought to have a pivotal role in motion processing; however, owing to their small size, it is difficult to obtain electrical recordings of T4 and T5 cells, leaving their visual response properties largely unknown. We circumvent this problem by means of optical recording from these cells in Drosophila, using the genetically encoded calcium indicator GCaMP5 (ref. 2). Here we find that specific subpopulations of T4 and T5 cells are directionally tuned to one of the four cardinal directions; that is, front-to-back, back-to-front, upwards and downwards. Depending on their preferred direction, T4 and T5 cells terminate in specific sublayers of the lobula plate. T4 and T5 functionally segregate with respect to contrast polarity: whereas T4 cells selectively respond to moving brightness increments (ON edges), T5 cells only respond to moving brightness decrements (OFF edges). When the output from T4 or T5 cells is blocked, the responses of postsynaptic lobula plate neurons to moving ON (T4 block) or OFF edges (T5 block) are selectively compromised. The same effects are seen in turning responses of tethered walking flies. Thus, starting with L1 and L2, the visual input is split into separate ON and OFF pathways, and motion along all four cardinal directions is computed separately within each pathway. The output of these eight different motion detectors is then sorted such that ON (T4) and OFF (T5) motion detectors with the same directional tuning converge in the same layer of the lobula plate, jointly providing the input to downstream circuits and motion-driven behaviours.

Aging affects early stage direction selectivity of MT cells in rhesus monkeys

The middle temporal area (MT/V5) plays an important role in motion processing. Neurons in this area have a strongly selective response to the moving direction of objects and as such, the selectivity of MT neurons was proposed to be a neural mechanism for the perception of motion. Our previous studies have found degradation in direction selectivity of MT neurons in old monkeys, but this direction selectivity was calculated during the whole response time and the results were not able to uncover the mechanism of motion perception over a time course. Furthermore, experiments have found that direction selectivity was enhanced by attention at a later stage. Therefore, the response should be excluded in experiments with anesthesia. To further characterize the neural mechanism over a time course, we investigated the age-related changes of direction selectivity in the early stage by comparing the proportions of direction selective MT cells in old and young macaque monkeys using in vivo single-cell recording techniques. Our results show that the proportion of early-stage-direction-selective cells is lower in old monkeys than in young monkeys, and that the early stage direction bias (esDB) of old MT cells decreased relative to young MT cells. Furthermore, the proportion of MT cells having strong early stage direction selectivity in old monkeys was decreased. Accordingly, the functional degradation in the early stage of MT cells may mediate perceptual declines of old primates in visual motion tasks.