Integral Role Research Articles

Beyond Postmodern Irony: Empathetic Storytelling in Hilary Mantel’s Beyond Black

The contemporary age, which has impacted the world and its inhabitants with a sense of anxiety and uncertainty, stemming from economic, political, global, and environmental events, has woven its effects into diverse scopes of life. In the late 20th century, the challenges facing the modern world intensified and peaked in the subsequent century due to events such as the 9/11 attacks, the 2008 global financial crisis, conflicts leading to refugee crises in regions like the Middle East, and environmental disasters like Chernobyl (1986) and Fukushima Daiichi (2011). Additionally, incidents such as the Exxon Valdez oil spill (1989), the Deepwater Horizon oil spill (2010), and the issue of global warming have further contributed to this heightened sense of risk and uncertainty, impacting both nations and individuals alike. Beside these various scopes of life, literature has also been impacted by the transformation of the world. The impact on literature has been particularly pronounced with embracing a sincere one on behalf of the author by abandoning the excessive irony and carefree attitude of postmodernism, signalling a transformation beyond the conventional realms of postmodernism. As Nicholas Stavris states in Supplanting the Postmodern (2015), “faced with a contemporary culture of anxiety, artists attempt to overcome the uncertainties of the human condition in the twenty-first century by reaching out for a renewed period of sincerity. Authenticity is the new focus for the present day artist” (p. 407). Similarly, in The Post-war Novel and the Death of the Author (2020) Arya Aryan remarks this positive change in literature by noting that a “new concept of authorship emerges in this more globalised and fragile new risk therapy culture for it produces pressures on novelists not only to embrace the New Sincerity but to return to the old eighteenth-century ideals of the novelist as a purveyor of moral sentiment within the new version of liberal economics” (p. 179). Hence, the change in the attitude of authors has led to the emergence of many new theories, which critique the excessive irony, detachment, and scepticism that characterize postmodern culture. Contemporary literature advocates for a return to sincerity, authenticity, and earnestness in literature by prioritising genuine emotion, connection and empathy. By examining the implications of this shift, this article explores Hilary Mantel’s Beyond Black (2005) within the context of metamodernism, aiming to reveal the discernible shift away from the detached irony of postmodernism towards a literary landscape that values sincerity and empathy. Through a detailed exploration of Mantel’s narrative choices, this analysis aims to uncover how the author places empathy at the forefront of storytelling. This article contends that Mantel’s work exemplifies a crucial transition in contemporary literature, highlighting the integral role of empathy in weaving one's life into the narrative fabric to overcome the challenges of the contemporary age, thereby portraying contemporary authors as more responsible and engaged in shaping the literary experience, bridging the gap between sincerity and irony.

Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila.

Liquid-liquid phase separation (LLPS) plays an integral role in various biological processes in eukaryotic organisms. Although several studies have highlighted its crucial role in modulating immune responses in mammals, its function in immune responses in Drosophila melanogaster remains poorly understood. Our study investigated the role of Cactin in LLPS and its implications for immune response modulation. We identified that phosphoglycerate kinase (PGK), an essential enzyme in the glycolytic pathway, phosphorylates Cactin, facilitating its transition from a relatively stable aggregated state to a more dynamic liquid droplet phase during the phase separation process. This transformation allows Cactin to rapidly interact with other cellular components, enhancing its antiviral properties and ultimately inhibiting virus replication. These findings expand our understanding of the role of LLPS in the antiviral defense mechanism, shedding light on the intricate mechanisms underlying immune responses in D. melanogaster.

Understanding Leadership for Learning of School Leaders in Disadvantaged Areas in the Context of Education Reform in Vietnam

ABSTRACT This study aims to explore the interrelationships between leaders’ personal traits, leadership behaviors, and leadership competencies for learning. This quantitative study utilizes structural equation modeling to analyze survey data collected from 563 school leaders across primary, secondary, and postsecondary schools situated in disadvantaged regions of Vietnam. Study participants from disadvantaged areas in Vietnam completed 20-item questionnaires, providing their perspectives on leader traits, leadership behaviors, and competencies related to leadership for learning. The findings revealed a positive correlation between leaders’ personal traits, leadership behaviors, and leadership competencies regarding learning. The research model successfully explained 54.70% of the variance in leadership competencies for learning. The results indicate instructional leadership behaviors have the most significant influence on competencies of leadership for learning, followed by shared leadership behaviors and transformational leadership behaviors. This highlights the integral role of school leaders in effectively implementing new curricula in Vietnam and advancing positive change, especially in disadvantaged schools. These insights hold practical implications for developing impactful leadership strategies in educational institutions to benefit students and shape a brighter future for Vietnam’s educational landscape.

Silence Speaks Volume in Samuel Beckett's Waiting for Godot and Krapp's Last Tape

Silence Speaks Volume in Samuel Beckett's Waiting for Godot and Krapp's Last Tape

Myeloid-Derived Suppressor Cells: Therapeutic Target for Gastrointestinal Cancers.

Gastrointestinal cancers represent one of the more challenging cancers to treat. Current strategies to cure and control gastrointestinal (GI) cancers like surgery, radiation, chemotherapy, and immunotherapy have met with limited success, and research has turned towards further characterizing the tumor microenvironment to develop novel therapeutics. Myeloid-derived suppressor cells (MDSCs) have emerged as crucial drivers of pathogenesis and progression within the tumor microenvironment in GI malignancies. Many MDSCs clinical targets have been defined in preclinical models, that potentially play an integral role in blocking recruitment and expansion, promoting MDSC differentiation into mature myeloid cells, depleting existing MDSCs, altering MDSC metabolic pathways, and directly inhibiting MDSC function. This review article analyzes the role of MDSCs in GI cancers as viable therapeutic targets for gastrointestinal malignancies and reviews the existing clinical trial landscape of recently completed and ongoing clinical studies testing novel therapeutics in GI cancers.

The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder–Fine-Grained Meta-Analyses

Background. While the brain correlates of major depressive disorder (MDD) have been extensively studied, there is no consensus conclusion so far. Various meta-analyses tried to determine the most consistent findings, but the results are often discordant for grey matter volume (GMV) atrophy and hypertrophy. Applying rigorous and stringent inclusion criteria and controlling for confounding factors, such as the presence of anxiety comorbidity, we carried out two novel meta-analyses on the existing literature to unveil MDD signatures. Methods. A systematic literature search was performed up to January 2023. Seventy-three studies on MDD patients reporting GMV abnormalities were included in the first meta-analysis, for a total of 6167 patients and 6237 healthy controls (HC). To test the effects of anxiety comorbidity, we conducted a second meta-analysis, by adding to the original pure MDD sample a new cohort of MDD patients with comorbid anxiety disorders (308 patients and 342 HC). An activation likelihood estimation (ALE) analysis and a coordinate-based mapping approach separate for atrophy and hypertrophy were used to identify common brain structural alterations among patients. Results. The pure MDD sample exhibited atrophy in the left insula, as well as hypertrophy in the bilateral amygdala and parahippocampal gyri. When we added patients with comorbid anxiety to the original sample, bilateral insula atrophy emerged, whereas the hypertrophy results were not replicated. Conclusions. Our findings revealed important structural alterations in pure MDD patients, particularly in the insula and amygdala, which play key roles in sensory input integration and in emotional processing, respectively. Additionally, the amygdala and parahippocampal gyrus hypertrophy may be related to MDD functional overactivation to emotional stimuli, rumination, and overactive self-referential thinking. Conversely, the presence of anxiety comorbidity revealed separate effects which were not seen in the pure MDD sample, underscoring the importance of strict inclusion criteria for investigations of disorder-specific effects.

Unlocking the Potential of AI/ML in DevSecOps: Effective Strategies and Optimal Practices

In the dynamic realm of technology, the fusion of Artificial Intelligence (AI) and Machine Learning (ML) with DevSecOps practices stands out as a pivotal catalyst for bolstering security, efficiency, and innovation in software development and deployment processes. This document explores effective strategies and optimal practices for maximizing the capabilities of AI/ML within the DevSecOps framework. Commencing with an overview of DevSecOps principles and the integral role of AI/ML, the document delves into specific tactics such as automated threat detection, predictive analytics for vulnerability management, and intelligent automation for continuous integration and deployment. Additionally, it addresses prominent challenges and considerations associated with the integration of AI/ML in DevSecOps, including data privacy, algorithm transparency, and ethical implications. Through illuminating case studies and real-world illustrations, the document showcases how organizations can leverage AI/ML technologies to streamline their DevSecOps pipelines, mitigate security risks, and cultivate a culture of ongoing enhancement. By embracing these strategies and adhering to best practices, organizations can harness the full potential of AI/ML to propel innovation, fortify resilience, and enhance agility in their DevSecOps endeavors.

Sounding Habitus: An Interdisciplinary Study on the Factors Influencing Musical Preferences

This paper employs Pierre Bourdieu’s concept of 'habitus' as a theoretical framework to scrutinize the multifaceted elements that influence musical preferences and inclinations in individuals. Drawing from an interdisciplinary approach, this study weaves historical accounts with empirical analyses conducted on scholarly articles primarily in sociology and educational studies. It seeks to explore how the constitutive factors of habitus, specifically education, Social Class Background, Cultural Background, and Ideology, affect one’s taste in music. The paper argues that these variables are not merely incidental but play an integral role in shaping a person’s musical predilections. Through a detailed examination of academic literature and historical contexts, the study further contends that understanding the complex web of these contributing factors can offer profound insights into not just musical tastes but also social hierarchies and cultural legitimacies. The findings aim to contribute to the existing discourse in both sociology of music and educational theory, offering a nuanced perspective on how identity is musically constructed and socially embedded.

Combining extracellular matrix proteome and phosphoproteome of chickpea and meta-analysis reveal novel proteoforms and evolutionary significance of clade-specific wall-associated events in plant.

Extracellular matrix (ECM) plays central roles in cell architecture, innate defense and cell wall integrity (CWI) signaling. During transition to multicellularity, modular domain structures of ECM proteins and proteoforms have evolved due to continuous adaptation across taxonomic clades under different ecological niche. Although this incredible diversity has to some extent been investigated at protein level, extracellular phosphorylation events and molecular evolution of ECM proteoform families remains unexplored. We developed matrisome proteoform atlas in a grain legume, chickpea and performed meta-analyses of 74 plant matrisomes. MS/MS analysis identified 1,424 proteins and 315 phosphoproteins involved in diverse functions. Cross-species ECM protein network identified proteoforms associated with CWI maintenance system. Phylogenetic characterization of eighteen matrix protein families highlighted the role of taxon-specific paralogs and orthologs. Novel information was acquired on gene expansion and loss, co-divergence, sub functionalization and neofunctionalization during evolution. Modular networks of matrix protein families and hub proteins showed higher diversity across taxonomic clades than among organs. Furthermore, protein families differ in nonsynonymous to synonymous substitution rates. Our study pointed towards the matrix proteoform functionality, sequence divergence variation, interactions between wall remodelers and molecular evolution using a phylogenetic framework. This is the first report on comprehensive matrisome proteoform network illustrating presence of CWI signaling proteins in land plants.

Implementing and testing a U-space system: lessons learnt

Within the framework of the European Union’s Horizon 2020 research and innovation program, one of the main goals of the Labyrinth project, which ended on May 2023, was to develop and test the Conflict Management services of a U-space-based Unmanned Traffic Management (UTM) system. The U-space ConOps provides a high-level description of the architecture, requirements and functionalities of these systems, but the implementer has a certain degree of freedom in aspects like the techniques used or some policies and procedures. The current document describes some of those implementation decisions. The prototype included, at least in a basic version, part of the services defined by the ConOps, namely e-identification, Tracking, Geo-awareness, Drone Aeronautical Information Management, Geo-fence Provision, Operation Plan Preparation/Optimization, Operation Plan Processing, Strategic and Tactical Conflict Resolution, Emergency Management, Monitoring, Traffic Information and Legal Recording. Besides, a web app interface was developed for the operator/pilot. The system was tested in simulations and real visual line of sight (VLOS) and beyond VLOS (BVLOS) flights, with both vertical take-off and landing (VTOL) and fixed-wing platforms, while assisting final users interested in incorporating drones to support their daily tasks. The three-year experience developing and testing the environment provided many lessons at different levels: functionalities, compatibility, procedures, information, usability, ground control station (GCS) integration and aircrew roles during the mission.

A CRITICAL REVIEW OF LABOUR COMMISSIONERS' DILEMMAS WHEN DEALING WITH WORKPLACE DISPUTES IN SOUTH AFRICA

Purpose: The overarching purpose of the study is to review the existing literature on the immense challenges faced by South African labour commissioners when dealing with labour disputes. Upholding decent work is indispensable to dispel injustice and poor working conditions at the workplace. Theoretical reference: It is one of the key sustainable development goals the United Nations sets in which South Africa is a member state. Labour commissioners of the Commission for Conciliation, Mediation and Arbitration in South Africa play an integral role in accomplishing decent work through adjudicating labour disputes between employees and employers. Method: The study adopted a systematic review method. The study extensively reviewed the available literature, which include published research articles, conference papers, reports and policy documents over the period 2012–2022 from Scopus, Web of Science, Google Scholar and ScienceDirect databases. Results and Conclusion: The study found unparalleled challenges, which include illiteracy and poor level of education among the complainants, mounting reported labour caseload, increase in labour matter reviews, re-filing of cases dealt with due to unimplemented awards, poor access to training of the commissioners, among others. Implications of research: The study provides critical policy implications to address labour commissioners' challenges in South Africa. The management must also ensure that the complainants have access to adequate technology whenever they contemplate conducting their dispute resolution process via digital platforms. Originality/value: However, despite labour commissioners facing challenges linked to their work, which compromise their ability to discharge their duties effectively, studies have yet to be conducted to specifically examine the challenges faced by labour commissioners in South Africa.

The local and systemic effects of immune function on fracture healing.

The immune system plays an integral role in the regulation of cellular processes responsible for fracture healing. Local and systemic influences on fracture healing correlate in many ways with fracture-related outcomes, including soft tissue healing quality and fracture union rates. Impaired soft tissue healing, restricted perfusion of a fracture site, and infection also in turn affect the immune response to fracture injury. Modern techniques used to investigate the relationship between immune system function and fracture healing include precision medicine, using vast quantities of data to interpret broad patterns of inflammatory response. Early data from the PRECISE trial have demonstrated distinct patterns of inflammatory response in polytrauma patients, which thereby directly and indirectly regulate the fracture healing response. The clearly demonstrated linkage between immune function and fracture healing suggests that modulation of immune function has significant potential as a therapeutic target that can be used to enhance fracture healing.

Fat digestion and absorption: Normal physiology and pathophysiology of malabsorption, including diagnostic testing.

Fat digestion and absorption play crucial roles in maintaining energy homeostasis and supporting essential physiological functions. The initial stage of fat digestion occurs in the stomach, where gastric lipase begins the hydrolysis of triglycerides. However, most fat digestion takes place in the small intestine via pancreatic enzymes and bile salts. Emulsification of fat by bile acids facilitates enzymatic action, breaking down triglycerides into free fatty acids and monoglycerides, which are then able to be absorbed by enterocytes. Fat malabsorption can result from various underlying conditions, such as exocrine pancreatic insufficiency, bile acid disorders, or intestinal diseases. The clinical manifestations of fat malabsorption include steatorrhea, malnutrition, and deficiencies of fat-soluble vitamins. Diagnostic approaches involve assessing fecal fat levels, imaging studies, and various functional tests to identify the specific etiology. This review article will describe the normal physiologic process of fat digestion and absorption and discuss various pathophysiology that can lead to fat malabsorption within the gastrointestinal tract as well as their respective diagnostic testing modalities. Effective digestion of fat is essential for overall health, because it allows for absorption of many essential nutrients, plays an integral role in cellular and structural function, and supplies energy to the body. When this is dysfunctional, disorders of malabsorption can occur. This article will give a brief overview of the physiologic process of fat digestion and absorption in healthy individuals as well as review important pathophysiology that can lead to fat malabsorption within the gastrointestinal tract and current diagnostic testing modalities.

Copula‐based Bayesian reliability assessment for series systems

AbstractBayesian reliability assessment plays an integral role in determining the success of product development and deployment into the market, especially when limited information is available to estimate the reliability of products. Nevertheless, the Bayesian reliability approach has untapped research potential when it is used to evaluate systems consisting of dependent components, that is, a situation that reflects real‐world conditions. This study addresses the research gap by applying a copula to encode the dependency structure between the failure rates of the components, particularly for the simple series systems. Unfortunately, this study found that Bayesian aggregation error still occurs when information is used at different levels. By employing Monte Carlo simulation and classification tree learning, this study also investigates the key factors affecting such error over a wide range of possible scenarios and derives useful guidelines for reliability practitioners so that they can choose a more suitable analysis under certain circumstances.

The Impact of Organizational Learning on Organizational Resilience: The Mediating Role of Knowledge Integration

The Impact of Organizational Learning on Organizational Resilience: The Mediating Role of Knowledge Integration

The influence of leadership and financial performance on business sustainability in microfinance institutions

Microfinance institutions (MFIs) play a pivotal role in empowering marginalized communities by providing them with crucial financial services. The sustainability of these institutions is essential to ensure a sustained positive impact on the lives of the underserved. To explore the factors influencing MFI sustainability, this study conducts a systematic literature review of relevant articles published between 2015 and 2023, focusing on the roles of leadership and financial performance. The findings of the study reveal a compelling positive correlation between effective leadership and financial performance with MFI sustainability. A strong and visionary leadership within MFIs is found to foster a robust organizational culture, articulate a clear vision, motivate employees, and effectively manage risks. These leadership qualities, in turn, contribute significantly to improved financial outcomes for the institution. Conversely, the study highlights the integral role of strong financial performance in ensuring MFI sustainability. A well-performing financial structure not only instills trust among customers but also facilitates business growth and secures vital profits. These financial strengths are crucial pillars that fortify the overall sustainability of MFIs, enabling them to continue their mission of empowering marginalized communities. In conclusion, this study underscores the critical interplay between leadership and financial performance in driving MFI sustainability. The recommendations derived from the findings emphasize the importance of investing in leadership development within MFIs and implementing robust financial practices.

Linking sustainable leadership with sustainable project performance: mediating role of knowledge integration and moderating role of top management knowledge values

Purpose The purpose of this study is to investigate the relationship between sustainable leadership and sustainable project performance. Specifically, the study aims to examine the mediating role of knowledge integration, examining how knowledge integration within an organization influences project outcomes. In addition, the study seeks to explore the moderating role of top management knowledge values, examining how the values and beliefs of top management influence the relationship between sustainable leadership and project performance. Design/methodology/approach A three-wave survey of 392 employees working in construction sector projects in Pakistan used both hierarchical regression analysis and Hayes’ PROCESS macro method to evaluate the hypotheses. Findings The study results show that sustainable leadership positively relates to sustainable project performance and knowledge integration mediating this relationship. In addition, the top management knowledge value moderates the indirect effect of sustainable leadership on sustainable project performance via knowledge integration. Research limitations/implications Although the model was tested using three-wave data, it is important to note that the data were obtained from a single source. Therefore, it is possible that common method bias may have influenced the results, and this cannot be disregarded. Practical implications Organizations seek to prioritize sustainability and integrate sustainability considerations into their project management processes. Organizations can achieve improved sustainable project performance by investing in sustainable leadership development, fostering a culture of knowledge sharing and learning, prioritizing top management support for sustainable performance and integrating sustainable considerations into project management processes. Originality/value The study’s grounding on organizational learning theory adds an original and valuable perspective to the relationship between sustainable leadership and sustainable project performance. This investigation is original, as it combines sustainable leadership, knowledge integration and the moderating role of top management knowledge value to understand their impact on sustainable project performance. This unique approach contributes to the literature by providing new insights into these relationships and mechanisms in the construction industry.

The basic leucine zipper transcription factor MeaB is critical for biofilm formation, cell wall integrity, and virulence in Aspergillus fumigatus.

The regulation of fungal cell wall biosynthesis is crucial for cell wall integrity maintenance and directly impacts fungal pathogen virulence. Although numerous genes are involved in fungal cell wall polysaccharide biosynthesis through multiple pathways, the underlying regulatory mechanism is still not fully understood. In this study, we identified and functionally characterized a direct downstream target of SomA, the basic-region leucine zipper transcription factor MeaB, playing a certain role in Aspergillus fumigatus cell wall integrity. Loss of meaB reduces hyphal growth, causes severe defects in galactosaminogalactan-mediated biofilm formation, and attenuates virulence in a Galleria mellonella infection model. Furthermore, the meaB null mutant strain exhibited hypersensitivity to cell wall-perturbing agents and significantly alters the cell wall structure. Transcriptional profile analysis revealed that MeaB positively regulates the expression of the galactosaminogalactan biosynthesis and β-1,3-glucanosyltransferase genes uge3, agd3, and sph3 and gel1, gel5, and gel7, respectively, as well as genes involved in amino sugar and nucleotide sugar metabolism. Further study demonstrated that MeaB could respond to cell wall stress and contribute to the proper expression of mitogen-activated protein kinase genes mpkA and mpkC in the presence of different concentrations of congo red. In conclusion, A. fumigatus MeaB plays a critical role in cell wall integrity by governing the expression of genes encoding cell wall-related proteins, thus impacting the virulence of this fungus.IMPORTANCEAspergillus fumigatus is a common opportunistic mold that causes life-threatening infections in immunosuppressed patients. The fungal cell wall is a complex and dynamic organelle essential for the development of pathogenic fungi. Genes involved in cell wall polysaccharide biosynthesis and remodeling are crucial for fungal pathogen virulence. However, the potential regulatory mechanism for cell wall integrity remains to be fully defined in A. fumigatus. In the present study, we identify basic-region leucine zipper transcription factor MeaB as an important regulator of cell wall galactosaminogalactan biosynthesis and β-1,3-glucan remodeling that consequently impacts stress response and virulence of fungal pathogens. Thus, we illuminate a mechanism of transcriptional control fungal cell wall polysaccharide biosynthesis and stress response. As these cell wall components are promising therapeutic targets for fungal infections, understanding the regulatory mechanism of such polysaccharides will provide new therapeutic opportunities.

The racial biopolitics of humanitarianism in Africa: examining European resilience-building in the Sahel and lake Chad Basin

The racial biopolitics of humanitarianism in Africa: examining European resilience-building in the Sahel and lake Chad Basin

Urban green infrastructure and its role in sustainable cities: A comprehensive review

Urban Green Infrastructure (UGI) plays a pivotal role in shaping sustainable cities by integrating natural elements into the urban landscape. This comprehensive review explores the multifaceted contributions of UGI towards enhancing environmental quality, social well-being, and economic resilience in urban settings. As cities continue to grapple with challenges such as climate change, air and water pollution, and the urban heat island effect, UGI emerges as a key solution for fostering urban sustainability. The review delves into the various components of UGI, encompassing green spaces, urban forests, green roofs, and permeable surfaces. It examines how these elements collectively contribute to mitigating environmental issues by absorbing carbon dioxide, reducing air pollutants, and attenuating the impacts of extreme weather events. Additionally, UGI serves as a biodiversity hotspot, supporting diverse flora and fauna within urban boundaries. Beyond its environmental benefits, UGI significantly influences social dynamics and well-being. The presence of green spaces fosters recreational opportunities, promotes mental health, and strengthens community cohesion. Accessible and well-designed green infrastructure contributes to equitable distribution of environmental benefits, addressing environmental justice concerns in urban areas. Economically, UGI proves to be an asset for cities by enhancing property values, reducing energy consumption through temperature regulation, and supporting local businesses. The review explores successful case studies of cities that have effectively implemented UGI to achieve sustainable urban development, drawing insights into best practices and potential challenges. This comprehensive review underscores the integral role of Urban Green Infrastructure in creating sustainable and resilient cities. By addressing environmental, social, and economic dimensions, UGI emerges as a holistic approach that aligns with the evolving needs of urban populations and the imperatives of a sustainable future. Understanding the intricacies of UGI implementation provides a foundation for policymakers, urban planners, and researchers to collaboratively work towards fostering greener, healthier, and more sustainable urban environments.