Imaging of the salivary glands is a diagnostic challenge because of the variety of disease processes that may show similar imaging findings. This article provides an overview of anatomy, epidemiology, clinical presentation, and imaging features of salivary gland tumors as well as inflammatory and systemic processes involving these glands. The imaging features with differential diagnoses are discussed with emphasis on computed tomography (CT) and magnetic resonance imaging (MRI). A variety of disease processes, including inflammatory, infectious, obstructive, systemic, and neoplastic processes can inflict the salivary glands. The diversity of benign and malignant salivary neoplasms is probably greater than that of any other organ system.1 Salivary tumors gland comprise 3% of all head and neck tumors and cause 0.1% of all cancer deaths. 2 As part of understanding the role of imaging in diagnosis of salivary gland disorders, normal anatomy of the glands is describedfirst in this review followed by discussion of individual disease entities.