Role Of Hematological Parameters Research Articles

Role of Hematological Parameters in the Early Diagnosis of Neonatal Sepsis.

The major cause of neonatal mortality and morbidity is bacterial sepsis. Blood culture is the most reliable method in neonatal sepsis. This study was conducted to study the usefulness of hematological parameters in the early diagnosis of neonatal sepsis and to assess the most sensitive and specific variables in diagnosing neonatal sepsis. This prospective study was conducted in a tertiary care hospital from January 2017 to January 2018. Peripheral blood smears were prepared from patients with clinical suspicion of sepsis or predisposing perinatal factors for sepsis and stained with Field's stain and examined. The hematological findings were analyzed according to the hematologic scoring system of Rodwell. It was found that immature PMN count, I: M ratio, and I: T ratio had the highest sensitivity (92.06%, 87.30%, and 74.60%, respectively) while I: M ratio, I: T ratio, and degenerative changes in PMN had the highest specificity (97.50%, 96.50%, and 94.0%, respectively) in the prediction of sepsis.

The Role of Hematological Parameters in Children with COVID-19, MIS-C, and Other Viral Infections

The Role of Hematological Parameters in Children with COVID-19, MIS-C, and Other Viral Infections

The Role of Hematological Parameters in the Diagnosis of Childhood Allergic Conjunctivitis

The Role of Hematological Parameters in the Diagnosis of Childhood Allergic Conjunctivitis

Role of Hematological Parameters in the Grading of COVID-19 and a Model to Predict the Outcome in Inpatients.

Introduction Human coronaviruses, identified in the 1960s, are known culprits of respiratory infections. Classified into alpha, beta, gamma, and delta subgroups, these viruses have the capacity to transition from animal reservoirs to causing severe respiratory ailments in humans. Notable outbreaks like the 2003 severe acute respiratory distress syndrome (SARS) epidemic and the ongoing coronavirus disease 2019 (COVID-19) pandemic underscore the recurring emergence of novel coronaviruses with severe human infection potential. COVID-19, driven by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a leading global cause of severe acute respiratory syndrome. Immune system disruptions and cytokine imbalances contribute to severe cases, necessitating early diagnosis and precise severity assessment. Methodology This retrospective cross-sectional study encompassed 211 COVID-19 patients admitted to AIIMS Patna from May to July 2020. Clinical and hematological parameters, including neutrophils, eosinophils, basophils, lymphocytes, monocytes, red and white blood cell counts, platelet count, C-reactive protein (CRP), serum ferritin, and d-dimer, were meticulously recorded. Patients were categorized into non-severe and severe groups using the National Early Warning Score (NEWS) 2. Results Our findings underscore the pivotal role of hematological markers in gauging COVID-19 severity. Notably, markers such as neutrophil-to-lymphocyte ratio (NLR), derived NLR, lymphocyte monocyte ratio, platelet lymphocyte ratio, d-dimer, CRP, and serum ferritin exhibited notable elevation in severe cases. Survival analysis further established the predictive potential of these markers in assessing disease progression and mortality risk. We advocate for the integration of these markers into existing severity assessment frameworks to foster objective clinical evaluations. Conclusion In conclusion, our study unravels the intricate connection between COVID-19 severity and hematological parameters. We emphasize the early warning capabilities of NLR, derived NLR, platelet lymphocyte ratio, and other markers in predicting disease progression. This research underscores the imperative need to incorporate hematological markers into the evaluation of COVID-19 severity, thereby providing invaluable insights for enhancing clinical practice and patient outcomes.

The Role of Hematological Parameters in Predicting the Death of Hospitalized Patients with COVID-19.

The role of the hematologic indicators in the identification of severe or critical patients requires further investigation. In this study, we focused on predicting Covid-19 patients at risk of progression using blood parameters. We performed a retrospective study including 444 patients with confirmed Covid-19. Hematological parameters were evaluated. The logistic regression analysis was performed with step-wise method with dependent variables such as intensive care units admission, partial pressure of oxygen saturation, and mortality. Also, independent variables such as hematological parameters, age and sex to assess variables that are likely to predict patients at risk of progression. Patients in intensive care units had significantly higher mean absolute neutrophil count than outpatients (P < 0.001). There was a statistically significant difference in the mean absolute lymphocyte count between dead and survived patients (P = 0.015). Multivariate analysis confirmed the positive association of the white blood cells (P < 0.001), absolute neutrophil count (P < 0.004), red cell distribution width (P < 0.001), and lactate dehydrogenase (P = 0.007) to be positively associated with the admission of Covid-19 patients in the intensive care units and the absolute monocyte count (P = 0.012, Odds ratios = 0.100, CI95% = 0.066-0.605) to be negatively associated with mortality. Based on the results of our study, it is recommended to use hematological data to make clinical decisions and evaluate the patient's prognosis.

Role of hematological parameters and biochemical markers as a predictor of severity of COVID-19 patients

Background: The etiological agent for pandemic COVID-19 is severe acute respiratory syndrome corona virus 2. Hematological and biochemical parameters are the indicators of inflammation and coagulopathy. Aims and Objectives: The present study aimed to determine how effectively the hematological parameters and biochemical markers can help predict the severity of critically ill COVID-19 patients. Materials and Methods: The current retrospective cohort study was conducted among 200 COVID-19 patients admitted in the Sanjay Gandhi Memorial Hospital, Rewa, Madhya Pradesh, India. In our lab’s computerized system, certain hematological and biochemical parameters of the patients were retrieved and recorded. Receiver operating characteristics (ROC) curve analysis was done to evaluate the diagnostic accuracy of hematological and biochemical parameters. Results: Total leukocyte count (TLC), absolute lymphocyte count (ALC), neutrophil to lymphocyte ratio (NLR), D-dimer, and serum ferritin had a significant relationship with severity among ICU patients (P&lt;0.05). ALC, D-dimer, and serum ferritin can be used to predict the severity of COVID patients with area under the ROC-AUC curve values of 0.717, 0.725, and 0.710, respectively. Platelet to lymphocyte ratio, lymphocyte to monocyte ratio, and C-reactive protein were not useful to predict the severity of COVID illness. Conclusion: Hb concentration, TLC, NLR, D-dimer, and serum ferritin were significantly raised in critically ill COVID patients. ROC curve analysis showed that ALC, serum ferritin, and D-dimer were able to predict the severity of COVID illness effectively. Conclusively, these parameters can be used to track the prognosis of patients.

Prognostic value of hematological parameters in childhood respiratory tract infections

Introduction. Respiratory tract infections (RTIs) represent a growing burden among pediatric populations, as their potential progression towards acute respiratory insufficiency (ARI), which requires hospitalization and can be light-threatening without adequate supportive measures. Several recent studies have tried to investigate the role of non-invasive depictable parameters, such as those easily determined through a complete blood count (CBC), in the prediction of potentially complicated RTIs. The aim of the current study is to assess whether changes in hematological parameters can predict the development of respiratory insufficiency in children with RTIs. Material and methods. A retrospective study was conducted on 80 patients hospitalized for RTIs, divided into two groups based on their complication by ARI: children with RTI and ARI (group 1-30 patients) and children with RTI, uncomplicated with ARI (group 2-50 patients). Patients with a previously known chronic or hematological disorder were excluded from the study. A CBC was carried out in each patient and C-reactive protein (CRP) values were also determined. Moreover, RT-PCR testing for SARS-COV2 infection was carried out in each child. Results. There were no significant differences in most of the hematological parameters analyzed between the two groups, with the exception of mean corpuscular hemoglobin concentration (MCHC), which exhibited lower values in study group 1. Insignificant differences in parameters of CBC were also found when performing a separate analysis on the subgroup of patients infected with SARS-COV2. However, significantly higher CRP values were found in subjects with RTIs complicated by ARI. An important decrease in hemoglobin levels, under 10 mg/dl, was not positively associated with a complicated outcome of RTIs. Conclusion. Hematological parameters, with the exception of MCHC, are not predictive of ARI in children diagnosed with RTIs. A separate analysis on cases diagnosed with SARS-COV2 infection revealed similar, insignificant results. Further studies, conducted on larger populations, could provide more data regarding the role of hematological parameters in the prediction of RTIs’ severity.

Role of Haematological Parameters and Oxidative Stress in Malarial Patients

Introduction: Malaria has been in existence for so long and is responsible for worrisome health and economic impact in different parts of the world. Objectives: The main objective of the study is to find the haematological parameters and oxidative stress in malarial patients. Material and methods: This cross sectional study was conducted in DHQ Hospital Bhakkar during 2020 to 2021. The data was collected from 200 male and female patients. Participants remembered for the review were under-5-year-old youngsters, either conceded in the kids' ward or going to any center on short term premise. Results: The information was gathered from 200 malarial patients. There was a genuinely huge decrease in hemoglobin (p&lt;0.005), platelet count (p&lt;0.001) and all out leukocyte count (p&lt;0.001) levels in patients with malaria contrasted with patients without the sickness. The level of neutrophils in the subjects with malaria was fundamentally higher (p&lt;0.005) than in the non-malaria bunch. Conclusion: It is inferred that Low platelet count is a trademark finding of malarial contamination and thrombocytopenia might be more normal than weakness in intense malaria disease.

The role of hematological parameters in differentiating Plasmodium falciparum and others – a study from Somalia

Introduction and aim. Accurate identification of Plasmodium species is important because of the differences in their treatment. We aimed to investigate the role of hematological and biochemical parameters in the differentiation of Plasmodium falciparum and other plasmodium species. Material and methods. This is a retrospective study. Patients admitted to the emergency department with signs and symptoms of malaria were included into the study. Patients with malaria were grouped as P. falciparum and others. Hematological parameters of two groups were compared by univariate and multivariate analysis. Statistical analysis was performed using the Jamovi. Results. A total of 107 patients were included in the study. According to univariant and multivariant analysis there was no difference in between two groups in the terms of blood urea nitrogen, aspartate aminotransferase, total bilirubin, hemoglobin, hematocrit, white blood cell count, platelet count, and mean platelet volume (in univariate analysis p values were 0.029, 0.011, 0.019, 0.171, 0.870, 0.307, 0.042, and 0.276, respectively and in multivariate analysis p values for blood urea nitrogen, aspartate aminotransferase, total bilirubin, hemoglobin, and platelet count were 0.100, 0.535, 0.328, and 0.213, respectively). Conclusion. The investigated hematological and biochemical parameters were found to be not valuable in predicting type of malaria. On the other hand, we recommend confirming the results of our study with larger samples and multicenter studies.

The role of haematological parameters in predicting the response to radical chemoradiotherapy in patients with anal squamous cell cancer.

BackgroundHistorically, the treatment of choice for anal cancer had been abdominoperineal resection (APR). Radical radiotherapy with concurrent 5-fluorouracil plus mitomycin C chemotherapy was later established as standard therapy, although with a failure rate of 20–30%. The aim of this study was to evaluate the outcomes after radical chemoradiotherapy (CRT), prognostic and predictive factors and patterns of failure.Patients and methodsThis study included 47 patients treated with radical CRT for patohistologicaly confirmed anal squamous cell carcinoma. Analysed haematological parameters included: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and haemoglobin level. The final logistic regression model included treatment break period. Tumour response was assessed at 24 weeks from CRT completion. Follow-up was performed every 3 months during the first two years, and every 6 months thereafter.ResultsA complete clinical response (CR) was detected in 30 patients (63.8%). Patients who did not achieve a 6-months CR and those who had a CR after 6 months but then relapsed were referred to surgical treatment. With combined CRT and surgical salvage treatment the CR rate was 80.9%. Patients with CR after 6 months had significantly longer disease-free survival (DFS), progression-free survival (PFS), and overall survival (OS). A significant effect on the 6-month response was confirmed for PLR (p = 0.03).ConclusionsImportant prognostic factors associated with CR were baseline haemoglobin level and period of treatment interruptions. Potential haematological prognostic factors could be PLR and NLR, which can be routinely determined by low-cost and minimally invasive methods.

Role of Hematological Parameters in Predicting Severity of Acute Venous Thromboembolism

Background- Many studies have shown that inflammation and clotting mechanisms are closely related. Hence, inflammatory markers such as Neutrophil-Lymphocyte ratio(NLR) and Platelet-Lymphocyte ratio (PLR) can be elevated in patients with acute venous thromboembolism (VTE) including deep vein thrombosis(DVT) and pulmonary embolism(PE) In this retrospective study, we evaluated the significance of NLR & PLR in predicting the severity of VTE.Methods -We retrospectively analyzed data of all patients who were diagnosed with first episode of DVT and PE from 01/2005 to 06/2015. Clinical data for 212 patients with DVT and PE and 58 random healthy controls (outpatient well visit) were collected from the electronic medical record system database of our 850 bed tertiary care center hospital.Results: The number of patients with VTE and healthy controls (C) were (DVT-115(54%), PE 97(46%)) and 58 respectively. The mean age DVT was 61.3 ± 16.3, PE 61.6 ± 16.2 & C 55.2 ± 16.6 years. The mean NLR VTE and C was 6.6±7.24 & 5.89±8.8 respectively. Mean PLR VTE and C was 17.15±17.18 & 17.49±17.5. Increased age was significantly associated with DVT (p=0.012) and PE (p=0.001). Odd for DVT in females were 1.7 (1.04-2.78; p=0.03) compared to males. Though there were no differences in odds of PE between sexes. In patients with DVT, PLR was higher in proximal v/s distal (p=0.014). Also, platelet counts were significantly lower in extensive DVT compared with either distal or proximal DVT (p=0.039). NLR was significantly higher in patients with central v/s distal PE (p=0.042). No significant differences were noticed in NLR, PLR or platelet counts between PE, DVT and C.Conclusion: In this study, inflammatory markers like NLR , PLR were increased with acute thrombosis. Moreover, the ratios were higher with proximal thrombosis both in central and peripheral venous system.Platelet counts were lower in extensive DVT probably from increased consumption. Thus the inflammatory markers when combined with traditional risk factors for DVT and PE can increase the probability of its diagnosis and predict the severity of thrombosis. DisclosuresNo relevant conflicts of interest to declare.

Role of Hematological Parameters: RDW, MPV, PDW as Predictive Markers in Prevention of Complications in Uncontrolled Type 2 DM (Diabetes Mellitus)

Role of Hematological Parameters: RDW, MPV, PDW as Predictive Markers in Prevention of Complications in Uncontrolled Type 2 DM (Diabetes Mellitus)

Role of hematological parameters in the diagnosis of influenza virus infection in patients with respiratory tract infection symptoms.

BackgroundThe differential diagnoses of patients hospitalized for respiratory infections due to influenza virus vs other pathogens are challenging. Our study investigated whether hematological parameters such as neutrophil (N), lymphocyte (L), platelet (PLT), and neutrophil‐to‐lymphocyte ratio (NLR) contributed in diagnosing influenza virus infections and in discriminating other respiratory infections.MethodsWe retrospectively analyzed the laboratory characteristics of 307 patients with respiratory infections caused by influenza/non‐influenza virus and bacteria. The diagnostic abilities of hematological indexes were evaluated in the patients compared with 100 healthy people.ResultsThe hematological parameters in patients with influenza virus infection were dramatically altered compared with those in the controls. Additionally, among the systemic inflammatory markers, the sensitivity of NLR for influenza detection was higher than that of N and L. PLT was significantly lower in influenza virus‐positive infection than in influenza virus‐negative infection. Moreover, when patients with influenza virus infection were cured, PLT returned to a normal level. The red blood cell (RBC) and hemoglobin (Hb) levels of influenza virus infection were higher than those of bacterial infection. Compared with traditional N and L, NLR and platelet‐to‐neutrophil (PNR) showed greater significance between influenza virus and bacterial infection (P < .01).ConclusionNeutrophil‐to‐lymphocyte ratio with high sensitivity is a preferable diagnostic tool to screen influenza virus‐infected patients than N and L. PLT accounts in the differential diagnoses of respiratory infections due to influenza virus and other pathogens among patients. In addition, RBC, Hb, NLR, and PNR can significantly differentiate between influenza virus infections and bacterial infections.

The Role of Hematologic Parameters in Recurrent Aphthous Stomatitis

Aim: Recurrent Aphthous Stomatitis (RAS) is one of the most common diseases of oral mucosa characterized by recurrent painful ulcers. Although many factors have been implicated in the etiology of the disease, it has not yet been fully elucidated. We aimed to investigate serum vitamin B12, ferritin, folate, vitamin D, hemoglobin, and thyroid stimulating hormone (TSH) levels in patients with RAS.Materials and Methods: The study involved in 60 patients (34 women, 26 men) with idiopathic RAS and 70 healthy volunteers (41 women, 29 men). The serum vitamin B12, ferritin, folate, vitamin D, hemoglobin, and TSH levels of the patients were measured and statistically compared.Results: Serum levels of vitamin B12 (204.5 vs. 301.0 pg/ml) and ferritin (31.0 vs. 48.5 ml/ng) were significantly lower and serum level of folate (7.7 vs. 6.7 ng/ml) were significantly higher in the patient group than control group (p0.05). No correlations were detected between RAS assessed by family history, mean duration of disease, and frequency of attacks and hematinic deficiencies. Conclusion: Vitamin B12 and ferritin deficiency can play a role in the underlying etiology of RAS therefore we suggested the investigation of the vitamin B12 and ferritin status in RAS patients.

The role of haematological parameters in patients with COVID-19 and influenza virus infection.

SARS-CoV-2, the causative agent of coronavirus disease 19 (COVID-19), was identified in Wuhan, China. Since then, the novel coronavirus started to be compared to influenza. The haematological parameters and inflammatory indexes are associated with severe illness in COVID-19 patients. In this study, the laboratory data of 120 COVID-19 patients, 100 influenza patients and 61 healthy controls were evaluated. Lower lymphocytes, eosinophils, basophils, platelets and higher delta neutrophil index (DNI), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were found in COVID-19 and influenza groups compared to healthy controls. The eosinophils, lymphocytes and PLR made the highest contribution to differentiate COVID-19 patients from healthy controls (area under the curves (AUCs): 0.819, 0.817 and 0.716, respectively; P-value is <0.0001 for all). The NLR, the optimal cut-off value was 3.58, which resulted in a sensitivity of 30.8 and a specificity of 100 (AUC: 0.677, P < 0.0001). Higher leucocytes, neutrophils, DNI, NLR, PLR and lower lymphocytes, red blood cells, haemoglobin, haematocrit levels were found in severe patients at the end of treatment. Nonsevere patients showed an upward trend for lymphocytes, eosinophils and platelets, and a downward trend for neutrophils, DNI, NLR and PLR. However, there was an increasing trend for eosinophils, platelets and PLR in severe patients. In conclusion, NLR and PLR can be used as biomarkers to distinguish COVID-19 patients from healthy people and to predict the severity of COVID-19. The increasing value of PLR during follow-up may be more useful compared to NLR to predict the disease severity.

The role of hematological parameters as predictors of mortality in elderly patients in the hospital period

The development of algorithms for predicting adverse outcomes, including death in elderly and senile patients, is an urgent issue. Potential predictors include hematologic parameters. A clinical blood test is one of the most affordable diagnostic methods in practical medicine, reflecting systemic pathological processes in the human body based on a quantitative assessment of the cellular composition and blood morphology. The aim of this study was to evaluate hematological parameters as predictors of in-hospital mortality in patients of the elderly and senile age with acute coronary syndrome. Material and methods . The study included 277 patients with acute coronary syndrome. The study of hematological parameters was carried out on a CELL-DYN Sapphire hematology analyzer (Abbott Laboratories, USA). The values of neutrophil-lymphocytes ratio and platelet-lymphocytes ratio were also evaluated as predictors of in-hospital mortality. Results . High content of leukocytes (above 10.45 x 10 9 /l) during hospitalization in patients with ACS aged 60-74 years are associated with a higher risk of death at the hospital stage. Among patients with ACS aged 75-89 years, the risk of death is associated with the following changes in peripheral blood upon admission: a decrease in the absolute number of eosinophils below 0.086 x 10 9 /l, an increase in the absolute number of basophils above 0.079 x 10 9 /l and a decrease in platelet-lymphocytes ratio below 31.06.

Hematological parameters in pediatric patients with primary headache

Aim: The present study aimed to evaluate the pain parameters in children with primary headache according to the International Classification of Headache Disorders, 3rd edition, diagnostic criteria and to investigate the role of hematological parameters in diagnosis in case the distinguish is difficult especially in children with migraine and tension headache. Materials and Methods: Medical data belonging age, gender, headache characteristics, hematological parameters of the outpatients with headache consulted in Beþtepe Child Neurology Outpatient Clinic of Dr. Sami Ulus Children's Hospital between July 2017 and August 2019 were examined retrospectively. SPSS statistical software was used to perform statistical data analysis. Results: A total of 243 patients (151 female, 92 male) were included in the study. The mean age was 13.68 ± 2.25 years. One hundred and one (58 female, 43 male) patients were diagnosed with migraine and 142 (93 female, 49 male) with tension type headache. Migraine presented the characteristics of unilateral (61.2%), pulsatile (88.5%) headache of moderate to severe intensity that worsens with physical activity, occurs usually in mornings (%46,5) and is accompanied by nausea or by photophobia and phonophobia (%34,3). Tension-type headache presented the characteristics of circumferential (53,2%), pressing (87.7%) headache of mild severe intensity that is triggered by school stress and accompanied phonophobia (65.2%), and occurs usually in evenings (55.3%). White blood cells, neutrophil, monocyte, monocyte-lymphocyte ratio and neutrophil-lymphocyte ratio were significantly higher in patients with migraine and lymphocyte and platelet counts were significantly higher in patients with tension type headache. Conclusion: In terms of shining a light on the future, consideration of the contribution of hematological parameters to differential diagnosis as a diagnostic support, due to the difficulties associated in particular with the presence of overlapping symptoms in the differential diagnosis of migraine and tension headache in childhood could make a significant difference.

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

The Role of Hematological Parameters in Predicting Fuhrman Grade and Tumor Stage in Renal Cell Carcinoma Patients Undergoing Nephrectomy.

Background and objective: We investigated the ability of preoperative serum values of red blood cell distribution width (RDW), neutrophil lymphocyte ratio (NLR) and plateletcrit (PCT) to predict Fuhrman grades (FG) and tumor stages of renal cell carcinoma in patients who underwent radical nephrectomy. Materials and methods: Records of 283 patients that underwent radical or partial nephrectomy of renal masses at our clinic between January 2010 and April 2018, whose pathology results indicated renal cell carcinoma (RCC), and who had their FG and T1–4 N0M0 identified were retrospectively evaluated. The patients were divided into two groups based on their FG as low (I–II) and high (III–IV) and their T stages were similarly grouped as limited to kidney (pT1–pT2) and not limited to kidney (pT3–pT4). Results: Mean RDW, NLR, PCT cut-off values of the patients for FG and T stage were 15.65%, 3.54, 0.28% and 14.35%, 2.69, 0.28%, respectively. The RDW and NLR were determined to be statistically significant predictors of a pathologically high FG, whereas the PCT value was not a statistically significant predictor of high FG (p = 0.003, p = 0.006, p = 0.075, respectively). The relationship of RDW, NLR and PCT values with a limited to the kidney pathological T stage revealed statistically significant correlations for all three values. Conclusions: We determined that only RDW and NLR were markers predicting FG, while PCT had no prognostic value. On the other hand, all three of these values were associated with a limited to the kidney pathological T stage in patients who underwent nephrectomy due to renal masses and whose pathologies suggested RCC.

The role of hematological parameters in estimating nosocomial sepsis

Background:Sepsis is a systemic inflammatory condition with high mortality rate. It is important to estimate nosocomial sepsis in order to manage the patients earlier. The aim of this study was to investigate the role of hematological parameters in estimating nosocomial sepsis.Material and Methods:A retrospective examination was conducted on 121 nosocomial sepsis patients between 01 January 2014 and 30 June 2017. Neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP) of the patients at the onset of sepsis were compared with baseline values.Results:The mean CRP level of the cohort at admission was 55±5.4 mg/dL and 139.2±6.2 mg/dL at the onset of sepsis (p 0.05). Significant correlation was found between CRP and NLR values at both admission (r=0.365, p<0.001) and at the onset of sepsis (r=0.261, p=0.004).Conclusion:We concluded that the NLR is a useful marker in estimating nosocomial sepsis especially when considered together with CRP.