The role of hematological parameters in estimating nosocomial sepsis

Hasan Tahsin Gozdas,Keziban Turken Gel,Makbule Tokur Kesgin,Aliye Yasayacak,Hayrettin Akdeniz

doi:10.29333/ejgm/108678

Hasan Tahsin Gozdas, Keziban Turken Gel + Show 3 more

Open Access

https://doi.org/10.29333/ejgm/108678

Copy DOI

Abstract

Background:Sepsis is a systemic inflammatory condition with high mortality rate. It is important to estimate nosocomial sepsis in order to manage the patients earlier. The aim of this study was to investigate the role of hematological parameters in estimating nosocomial sepsis.Material and Methods:A retrospective examination was conducted on 121 nosocomial sepsis patients between 01 January 2014 and 30 June 2017. Neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP) of the patients at the onset of sepsis were compared with baseline values.Results:The mean CRP level of the cohort at admission was 55±5.4 mg/dL and 139.2±6.2 mg/dL at the onset of sepsis (p 0.05). Significant correlation was found between CRP and NLR values at both admission (r=0.365, p<0.001) and at the onset of sepsis (r=0.261, p=0.004).Conclusion:We concluded that the NLR is a useful marker in estimating nosocomial sepsis especially when considered together with CRP.

Highlights

Sepsis is a systemic inflammatory condition triggered by microbial components
Excessive systemic inflammation as a consequence of impaired immune response has been shown to be related to worse outcome in sepsis patients [11,12]
During a systemic inflammatory response, significant changes are seen in white blood cell (WBC) counts that present as neutrophilia and/or relative lymphocytopenia [13]

Summary

Introduction

Sepsis is a systemic inflammatory condition triggered by microbial components. Nosocomial sepsis is classically defined as one which develops in a patient after 48–72 hours of hospital admission and is a significant cause of mortality in critically ill patients [1,2]. The diagnostic sensitivity of a blood culture decreases if antibiotic treatment is initiated before setting up the culture or if the pathogens are slow growing [3] Other tests such as complete blood counts, biochemical assays, and C-reactive protein (CRP) levels are often conducted simultaneously with blood culture if sepsis is suspected. Neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP) of the patients at the onset of sepsis were compared with baseline values. The differences in white blood cell, and mean platelet volume values at admission and sepsis onset were not statistically significant (p>0.05). Significant correlation was found between CRP and NLR values at both admission (r=0.365, p

Objectives

Methods

Results

Conclusion