Hypothyroidism refers to deficiency of thyroid hormones. It is potentially fatal if left untreated. It is more commonly seen in females and can be classified on the basis of age, severity, and etiology. Clinical manifestations of hypothyroidism range from subtle changes to life-threatening condition. The most common features are fatigue, lethargy, cold intolerance, weight gain, puffy face, constipation, change in voice, decreased mental activity, and dry skin. Oral manifestations include over-retained deciduous teeth, macroglossia, anterior open bite, enamel hypoplasia, enamel defects, poor periodontal health, and increased incidence of caries. Oral physicians play an important role in early diagnosis of this condition by identifying various signs and symptoms and thus prevent complications associated with dental treatment of such patients. Here, we are presenting a case of hypothyroidism in a 15-year-old female patient diagnosed by oral physician, highlighting the role of dentists in management of such cases.