W E ASSUNIE t h a t psych ic 1)henomena d e p e n d on the b ra in func t ion . T h e b ra in func t ion consists at the ce l lu la r level of ne rvous i m p u l s e s i n the • ~s w h i c h , r~. n ~ u r o n e . 't , t r ansmi t t ed from one n e u r o n e to t h e o t h e r b y m e a n s o f c h e m i c a l t r ansmi t t e r subs tancos in the synapses . Viz., n o r m a l p sych i c phen o m e n a d e p e n d i n t e r alia on a no rma l func t ion of the t ransmi t te rs . S c h i z o p h r e n i a m i g h t then be due to some d iS turbance in the t r ansmi t t e r funct ion , a l t hough of course there are o ther possibi l i t ies . \Ve have now eviderme a b o u t the exis tence (3}, t:our d i f fe ren t t r ansmi t t e r s in the bra in : d o p a m i n e , noradrena l i l , e , ,,er( ~tonin and ace tv lchol ine . It seems l ikely that there are o ther t ransmit ters , bUt there is not st~fficm~t~ e v i d e n c e abou t that. VG_,, find in the l i te ra ture sev~ral observa t ions wh ich sugges t tha t abnor ma l i t i e s in thc t r ansmi t t e r func t ion rea l ly do occur it? ;chizophrenia . In the fol lowing, I shall t ry to give a cri t ical su rvey of some re l evan t da ta and v iewpoin t s and point on some ,~'._at~ in our knov,,led~o a n d poin t on some pcr t ine~t research p rob lems .