Role Of Aldosterone In Pathogenesis Research Articles

Background: previous studies showed the role of aldosterone in pathogenesis of metabolic syndrome. The aim of this study was analysis the relation between plasma aldosterone (PA) and metabolic syndrome (MetS) and its components by comparison of PA in subjects with and without MetS. Methods: This cross-sectional study was designed on an Iranian sample in two groups with and without MetS (240 people in all). Aldosterone level in both groups was measured and then compared with presence of MetS and its components (waistline circumference, HDL, FBS and TG). Finally al of gathered data was analyzed using SPSS-17 software. Results: No significant differences between mean PA level in subjects with and without MetS were seen. In subjects without MetS, HDL was positively correlated with plasma aldosterone (r=0.294, p<0.001) and TG was inversely correlated with PA (r=-0.220, p=0.012). In subjects with MetS plasma aldosterone correlated positively with FBS (r=0.228, p=0.021). With increasing age and metabolic risk factors, PA level was decreased. Conclusion: This result suggests that aldosterone may contribute some roles in early stages of metabolic syndrome, not in late stage of the syndrome. These findings need to be evaluated in future studies and the positive association of aldosterone with HDL needs to be more explained.