Introduction. The world of professions of the future in the field of medicine is in transformation constantly, acquiring features of dynamism, unpredictability and uncertainty, that’s why pre-adaptation of medical college students to the uncertainty of the professional future plays an important role in vocational training. Uncertainty of the professional future of today’s youth and radical transformations of the socio-professional environment require qualitative changes in secondary vocational education, revision of its methodology, content and technologies for training medical personnel for the post-industrial economy. Purpose setting. The purpose of the study is to develop and theoretically and methodologically justify the structural and functional model of the process of pre-adaptation of medical college students to the uncertainty of their professional future, the introduction of which into the educational process of institutions of secondary vocational education will achieve the desired result ‒ the readiness of medical students for the uncertainty of their professional future. Methodology of the study. The methodological basis of the study was systemic, competency-based, personalized, design and technological, contextual, and process approaches and the principles of mobility, variability, integrativity, reflexivity, focus on professional self-determination. The leading research method was the modeling method. Results. The simulation result is a structural-functional model of the process of pre-adaptation of medical college students to the uncertainty of their professional future, which includes four interrelated blocks: target, methodological, procedural-substantial and result-evaluative. The model allows forming the anticipatory readiness of medical students for professional activities in conditions of high uncertainty, instability and variability. It has the property of dynamism and openness for constant renewal. Conclusion. Scientific novelty is as follows: the essence and structure of the basic concepts are determined; justified the principles and methods of the process of pre-adaptation; a structural-functional model has been developed; substantiated and described organizational-pedagogical conditions. The results of the scientific work also allow us to outline the prospects for further research, which consist in the practical implementation of this model, the inclusion of the process of pre-adaptation in educational activities and the development of mechanisms for its evaluation from the standpoint of achieving the expected effects. The results can be applied by teachers in the process of professional education.