Role In Spatial Cognition Research Articles

The retrosplenial cortical role in delayed spatial alternation

The retrosplenial cortex (RSC) plays an important role in spatial cognition. RSC neurons exhibit a variety of spatial firing patterns and lesion studies have found that the RSC is necessary for spatial working memory tasks. However, little is known about how RSC neurons might encode spatial memory during a delay period. In the present study, we trained control rats and rats with excitotoxic lesions of the RSC on spatial alternation task with varying delay durations and in a separate group of rats, we recorded RSC neuronal activity as the rats performed the alternation task. We found that RSC lesions significantly impaired alternation performance, particularly at the longest delay duration. We also found that RSC neurons exhibited reliably different firing patterns throughout the delay periods preceding left and right trials, consistent with a working memory signal. These differential firing patterns were absent during the delay periods preceding errors. We also found that many RSC neurons exhibit a large spike in firing rate leading up to the start of the trial. Many of these trial start responses also differentiated left and right trials, suggesting that they could play a role in priming the ‘go left’ or ‘go right’ behavioral responses. Our results suggest that these firing patterns represent critical memory information that underlies the RSC role in spatial working memory.

Current perspectives on vestibular insights into spatial cognition: A narrative review

Abstract: Conventionally, the focus on vestibular information has centered on basic functions such as adjusting eye movements, controlling posture, and gaze stabilization. However, there has been a noteworthy transformation in recent years as researchers seek to unravel the mysterious relationship between the vestibular system and spatial cognition. This narrative review endeavors, to provide a thorough analysis of current perspectives by delving into a vast body of research in this domain. The principal aim is to critically assess existing studies, offering nuanced insights into the complex interplay between the vestibular system and spatial abilities. For this the electronic database such as PubMed, EMBASE, CINAHL, and Google Scholar was searched for available literature from 2014 onward based on inclusion and exclusion criteria. After reviewing the literature by different authors, a brief review was conceptualized from the same. This article thoroughly explores brain regions related to vestibular function and their connections to spatial orientation and clinical implications. It identifies research gaps and proposes future avenues to deepen our understanding of the vestibular system’s role in spatial cognition, aiming for a holistic perspective. The intricate link between the vestibular system and spatial memory processing is a significant area in neuroscience, with vestibular exercises holding potential for personalized interventions, emphasizing the need to address research gaps for optimal cognitive well-being.

The Retrosplenial Cortical Role in Delayed Spatial Alternation.

The retrosplenial cortex (RSC) plays an important role in spatial cognition. RSC neurons exhibit a variety of spatial firing patterns and lesion studies have found that the RSC is necessary for spatial working memory tasks. However, little is known about how RSC neurons might encode spatial memory during a delay period. In the present study, we trained control rats and rats with excitotoxic lesions of the RSC on spatial alternation task with varying delay durations and in a separate group of rats, we recorded RSC neuronal activity as the rats performed the alternation task. We found that RSC lesions significantly impaired alternation performance, particularly at the longest delay duration. We also found that RSC neurons exhibited reliably different firing patterns throughout the delay periods preceding left and right trials, consistent with a working memory signal. These differential firing patterns were absent during the delay periods preceding errors. We also found that many RSC neurons exhibit a large spike in firing rate leading up to the start of the trial. Many of these trial start responses also differentiated left and right trials, suggesting that they could play a role in priming the 'go left' or 'go right' behavioral responses. Our results suggest that these firing patterns represent critical memory information that underlies the RSC role in spatial working memory.

Timing of Allocentric and Egocentric Spatial Processing in Human Intracranial EEG

Spatial reference frames (RFs) play a key role in spatial cognition, especially in perception, spatial memory, and navigation. There are two main types of RFs: egocentric (self-centered) and allocentric (object-centered). Although many fMRI studies examined the neural correlates of egocentric and allocentric RFs, they could not sample the fast temporal dynamics of the underlying cognitive processes. Therefore, the interaction and timing between these two RFs remain unclear. Taking advantage of the high temporal resolution of intracranial EEG (iEEG), we aimed to determine the timing of egocentric and allocentric information processing and describe the brain areas involved. We recorded iEEG and analyzed broad gamma activity (50–150 Hz) in 37 epilepsy patients performing a spatial judgment task in a three-dimensional circular virtual arena. We found overlapping activation for egocentric and allocentric RFs in many brain regions, with several additional egocentric- and allocentric-selective areas. In contrast to the egocentric responses, the allocentric responses peaked later than the control ones in frontal regions with overlapping selectivity. Also, across several egocentric or allocentric selective areas, the egocentric selectivity appeared earlier than the allocentric one. We identified the maximum number of egocentric-selective channels in the medial occipito-temporal region and allocentric-selective channels around the intraparietal sulcus in the parietal cortex. Our findings favor the hypothesis that egocentric spatial coding is a more primary process, and allocentric representations may be derived from egocentric ones. They also broaden the dominant view of the dorsal and ventral streams supporting egocentric and allocentric space coding, respectively.

NeuroAI: If grid cells are the answer, is path integration the question?

Spatially modulated neurons known as grid cells are thought to play an important role in spatial cognition. A new study has found that units with grid-cell-like properties can emerge within artificial neural networks trained to path integrate, and developed a unifying theory explaining the formation of these cells which shows what circuit constraints are necessary and how learned systems carry out path integration.

Negation and underlying spatial cognition: The evolution of Chinese mei (you) as a case study

ABSTRACT Negation and spatial experiences are basic to human cognition. While both should be indispensable to the exploration of each other, the relationship between them has seldom been touched upon. This study takes the Chinese negative marker mei (you) as a case study by investigating its evolutionary path in relation to spatial cognition. Drawing on corpus-based data across three historical stages before Modern Chinese, the study yields the following findings. First, the original meaning of mei involves dynamic spatial movement, which can extend to abstract domains. Second, rich concrete meanings of mei trigger semantic schematization at the second stage, spatial cognition playing a fundamental role. Third, the negative marker use of mei combines with you at the third stage, which is attributed to the fact that the spatial existence of you fits with the semantic component of existence in mei. The significance of the study lies in three aspects: first, the division of historical stages accords with the key turning points in the evolution of Chinese; second, the exploration follows a diachronic development, instead of being based merely on static performance; and third, this perspective sheds light on the role of spatial cognition in the conceptualization of negation in both Chinese and other languages.

Do people prefer a landmark route over a shortest route?

ABSTRACT Landmarks play an important role in spatial cognition, and therefore should be considered as a part of pedestrian navigation. This research addressed the question of human preference for landmark routes that are generated based on landmarks over shortest-distance optimized routes. We investigated whether there are differences regarding navigation behavior, navigation satisfaction, route memorization, route communication, and route comparison between the shortest and the landmark route. We did not observe any differences for navigation behavior, route memorization, and route communication. We observed that for the landmark route the participants were significantly faster in reversing the route. Generally, we found out that the participants were more satisfied with the shortest route and preferred the shortest route. We found hints that this might result from environmental parameters, which seemed to have an impact on navigation satisfaction. Additionally, the participants perceived the routes to be longer than they really were.

Replacing vertical actions by mouse movements: a web-suited paradigm for investigating vertical spatial associations

The number of web-based studies in experimental psychology has been growing tremendously throughout the last few years. However, a straightforward web-based implementation does not exist for all types of experimental paradigms. In the current paper, we focus on how vertical response movements—which play a crucial role in spatial cognition and language research—can be translated into a web-based setup. Specifically, we introduce a web-suited counterpart of the vertical Stroop task (e.g., Fox & Shor, in Bull Psychon Soc 7:187–189, 1976; Lachmair et al., in Psychon Bull Rev 18:1180–1188, 2011; Thornton et al., in J Exp Psychol Hum Percept Perform 39:964–973, 2013). We employed nouns referring to entities typically located in lower or upper vertical space (e.g., “worm” and “bird”, respectively) in Experiments 1 and 2, and emotional valence words associated with a crouched or an upward bodily posture (e.g., “sadness” and “excitement”, respectively) in Experiment 3. Depending on the font color, our participants used their mouse to drag the words to the lower or upper screen location. Across all experiments, we consistently observed congruency effects analogous to those obtained with the lab paradigm using actual vertical arm movements. Consequently, we conclude that our web-suited paradigm establishes a reliable approach to examining vertical spatial associations.

TriangleConv: A Deep Point Convolutional Network for Recognizing Building Shapes in Map Space

The classification and recognition of the shapes of buildings in map space play an important role in spatial cognition, cartographic generalization, and map updating. As buildings in map space are often represented as the vector data, research was conducted to learn the feature representations of the buildings and recognize their shapes based on graph neural networks. Due to the principles of graph neural networks, it is necessary to construct a graph to represent the adjacency relationships between the points (i.e., the vertices of the polygons shaping the buildings), and extract a list of geometric features for each point. This paper proposes a deep point convolutional network to recognize building shapes, which executes the convolution directly on the points of the buildings without constructing the graphs and extracting the geometric features of the points. A new convolution operator named TriangleConv was designed to learn the feature representations of each point by aggregating the features of the point and the local triangle constructed by the point and its two adjacency points. The proposed method was evaluated and compared with related methods based on a dataset consisting of 5010 vector buildings. In terms of accuracy, macro-precision, macro-recall, and macro-F1, the results show that the proposed method has comparable performance with typical graph neural networks of GCN, GAT, and GraphSAGE, and point cloud neural networks of PointNet, PointNet++, and DGCNN in the task of recognizing and classifying building shapes in map space.

Requirements of Postnatal proBDNF in the Hippocampus for Spatial Memory Consolidation and Neural Function.

Mature brain-derived neurotrophic factor (BDNF) and its downstream signaling pathways have been implicated in regulating postnatal development and functioning of rodent brain. However, the biological role of its precursor pro-brain-derived neurotrophic factor (proBDNF) in the postnatal brain remains unknown. The expression of hippocampal proBDNF was blocked in postnatal weeks, and multiple behavioral tests, Western blot and morphological techniques, and neural recordings were employed to investigate how proBDNF played a role in spatial cognition in adults. The peak expression and its crucial effects were found in the fourth but not in the second or eighth postnatal week. Blocking proBDNF expression disrupted spatial memory consolidation rather than learning or memory retrieval. Structurally, blocking proBDNF led to the reduction in spine density and proportion of mature spines. Although blocking proBDNF did not affect N-methyl-D-aspartate (NMDA) receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunits, the learning-induced phosphorylation of the GluN2B subunit level declined significantly. Functionally, paired-pulse facilitation, post-low-frequency stimulation (LFS) transiently enhanced depression, and GluN2B-dependent short-lasting long-term depression in the Schaffer collateral-CA1 pathway were weakened. The firing rate of pyramidal neurons was significantly suppressed around the target region during the memory test. Furthermore, the activation of GluN2B-mediated signaling could effectively facilitate neural function and mitigate memory impairment. The findings were consistent with the hypothesis that postnatal proBDNF played an essential role in synaptic and cognitive functions.

Genetic variants of the type-3 metabotropic glutamate receptor gene associated with human spatial localization ability

People present and transform spatial information through spatial cognitive abilities to learn and adapt to the environment. Accumulating evidence exhibits individual difference in spatial cognition, which is ascribed to environmental and genetic factors. The detail knowledge remains to be investigated. In this study, 941 healthy college students were recruited, and their spatial localization ability, an essential symbol of spatial cognitive ability, was measured. We analyzed the individual difference in spatial localization and relative influence factors. We selected the type-3 metabotropic glutamate receptor (GRM3) gene to dissect the genetic role in spatial cognition. In this study, both individual general cognitive ability and spatial localization were influenced by age, birthplace, growing environment, occupation and educational level of parent, and genetic variants of GRM3. The variants of GRM3 were significantly associated with spatial localization, and not associated with general cognitive ability. The carriers of the AA of rs6465084 or the TT of rs1468412 exhibited a weak spatial localization ability, and even the relative non-genetic factors above-mentioned were well controlled. Conclusion: Our results suggest that genetic variants of GRM3 are significantly associated with the spatial localization ability in the healthy people.

A Spatial Cognitive Model that Integrates the Effects of Endogenous and Exogenous Information on the Hippocampus and Striatum

Reproducing the spatial cognition of animals using computational models that make agents navigate autonomously has attracted much attention. Many biologically inspired models for spatial cognition focus mainly on the simulation of the hippocampus and only consider the effect of external environmental information (i.e., exogenous information) on the hippocampal coding. However, neurophysiological studies have shown that the striatum, which is closely related to the hippocampus, also plays an important role in spatial cognition and that information inside animals (i.e., endogenous information) also affects the encoding of the hippocampus. Inspired by the progress made in neurophysiological studies, we propose a new spatial cognitive model that consists of analogies between the hippocampus and striatum. This model takes into consideration how both exogenous and endogenous information affects coding by the environment. We carried out a series of navigation experiments that simulated a water maze and compared our model with other models. Our model is self-adaptable and robust and has better performance in navigation path length. We also discuss the possible reasons for the results and how our findings may help us understand real mechanisms in the spatial cognition of animals.

Thalamic afferents emphasize the different functions of macaque precuneate areas

We studied the thalamic afferents to cortical areas in the precuneus using injections of retrograde fluorescent neuronal tracers in four male macaques (Macaca fascicularis). Six injections were within the limits of cytoarchitectural area PGm, one in area 31 and one in area PEci. Precuneate areas shared strong input from the posterior thalamus (lateral posterior nucleus and pulvinar complex) and moderate input from the medial, lateral, and intralaminar thalamic regions. Area PGm received strong connections from the subdivisions of the pulvinar linked to association and visual function (the medial and lateral nuclei), whereas areas 31 and PEci received afferents from the oral division of the pulvinar. All three cytoarchitectural areas also received input from subdivisions of the lateral thalamus linked to motor function (ventral lateral and ventral anterior nuclei), with area PEci receiving additional input from a subdivision linked to somatosensory function (ventral posterior lateral nucleus). Finally, only PGm received substantial limbic association afferents, mainly via the lateral dorsal nucleus. These results indicate that area PGm integrates information from visual association, motor and limbic regions of the thalamus, in line with a hypothesized role in spatial cognition, including navigation. By comparison, dorsal precuneate areas (31 and PEci) are more involved in sensorimotor functions, being akin to adjacent areas of the dorsal parietal cortex.

A LANDMARK EXTRACTION METHOD ASSOCIATED WITH GEOMETRIC FEATURES AND LOCATION DISTRIBUTION

Abstract. Landmark plays an important role in spatial cognition and spatial knowledge organization. Significance measuring model is the main method of landmark extraction. It is difficult to take account of the spatial distribution pattern of landmarks because that the significance of landmark is built in one-dimensional space. In this paper, we start with the geometric features of the ground object, an extraction method based on the target height, target gap and field of view is proposed. According to the influence region of Voronoi Diagram, the description of target gap is established to the geometric representation of the distribution of adjacent targets. Then, segmentation process of the visual domain of Voronoi K order adjacent is given to set up target view under the multi view; finally, through three kinds of weighted geometric features, the landmarks are identified. Comparative experiments show that this method has a certain coincidence degree with the results of traditional significance measuring model, which verifies the effectiveness and reliability of the method and reduces the complexity of landmark extraction process without losing the reference value of landmark.

Retrosplenial cortex and its role in spatial cognition.

Retrosplenial cortex is a region within the posterior neocortical system, heavily interconnected with an array of brain networks, both cortical and subcortical, that is, engaged by a myriad of cognitive tasks. Although there is no consensus as to its precise function, evidence from both human and animal studies clearly points to a role in spatial cognition. However, the spatial processing impairments that follow retrosplenial cortex damage are not straightforward to characterise, leading to difficulties in defining the exact nature of its role. In this article, we review this literature and classify the types of ideas that have been put forward into three broad, somewhat overlapping classes: (1) learning of landmark location, stability and permanence; (2) integration between spatial reference frames; and (3) consolidation and retrieval of spatial knowledge (schemas). We evaluate these models and suggest ways to test them, before briefly discussing whether the spatial function may be a subset of a more general function in episodic memory.

Response properties of place cells in the hippocampus of freely moving pigeons

Place cells are considered to be the basic unit of cognitive maps, which play an important role in spatial cognition for many animals. To investigate the neural mechanisms underlying spatial cognition in birds, we designed four spatial cognitive tasks with or without goals, using pigeons as an animal model. We examined place cells in the hippocampus of 12 pigeons while they performed each task. We measured their spatial response properties and comparatively analyzed place field properties between tasks with and without goals using qualitative and quantitative measures. The results revealed that the reliability of place fields increased when the presence of a goal was clearer, and that place fields were more easily activated in tasks with a goal compared with those with no goal. In addition, we found that place cells in the hippocampus generally possessed multiple place fields, with an average of 2.7 place fields for each place cell. Place fields recorded simultaneously were always located in a similar position, and most exhibited overlapping regions. These results will be helpful for extending our understanding of the mechanisms underlying spatial cognition in different species, and provide a foundation for future studies investigating three-dimensional spatial cognition and navigation mechanisms in pigeons.

Using Pharmacological Manipulation and High-precision Radio Telemetry to Study the Spatial Cognition in Free-ranging Animals.

An animal's ability to perceive and learn about its environment plays a key role in many behavioral processes, including navigation, migration, dispersal and foraging. However, the understanding of the role of cognition in the development of navigation strategies and the mechanisms underlying these strategies is limited by the methodological difficulties involved in monitoring, manipulating the cognition of, and tracking wild animals. This study describes a protocol for addressing the role of cognition in navigation that combines pharmacological manipulation of behavior with high-precision radio telemetry. The approach uses scopolamine, a muscarinic acetylcholine receptor antagonist, to manipulate cognitive spatial abilities. Treated animals are then monitored with high frequency and high spatial resolution via remote triangulation. This protocol was applied within a population of Eastern painted turtles (Chrysemys picta) that has inhabited seasonally ephemeral water sources for ~100 years, moving between far-off sources using precise (± 3.5 m), complex (i.e., non-linear with high tortuosity that traverse multiple habitats), and predictable routes learned before 4 years of age. This study showed that the processes used by these turtles are consistent with spatial memory formation and recall. Together, these results are consistent with a role of spatial cognition in complex navigation and highlight the integration of ecological and pharmacological techniques in the study of cognition and navigation.

Neuroanatomy of the Parietal Association Areas

The parietal association cortex comprises the superior and inferior parietal lobules, the precuneus and the cortices in the intraparietal, parietooccipital and lunate sulci. By processing somatic, visual, acoustic and vestibular sensory information, the parietal association cortex plays a pivotal role in spatial cognition and motor control of the eyes and the extremities. Sensory information from the primary and secondary somatosensory areas enters the superior parietal lobule and is transferred to the inferior parietal lobule. Visual information is processed through the dorsal visual pathway and it reaches the inferior parietal lobule, the intraparietal sulcus and the precuneus. Acoustic information is transferred posteriorly from the primary acoustic area, and it reaches the posterior region of the inferior parietal lobule. The areas in the intraparietal sulcus project to the premotor area, the frontal eye fields, and the prefrontal area. These areas are involved in the control of ocular movements, reaching and grasping of the upper extremities, and spatial working memory. The posterior region of the inferior parietal lobule and the precuneus both project either directly, or indirectly via the posterior cingulate gyrus, to the parahippocampal and entorhinal cortices. Both these areas are strongly associated with hippocampal functions for long-term memory formation.

Human Hippocampal Theta Oscillations during Movement without Visual Cues

The hippocampus exhibits theta oscillations when animals navigate. Vass et al. (2016) discovered that theta oscillations are also present when humans are moved through a virtual environment without sensory feedback, indicating that theta oscillations have a general role in spatial cognition beyond sensorimotor processing.

Pharmacological evidence is consistent with a prominent role of spatial memory in complex navigation.

The ability to learn about the spatial environment plays an important role in navigation, migration, dispersal, and foraging. However, our understanding of both the role of cognition in the development of navigation strategies and the mechanisms underlying these strategies is limited. We tested the hypothesis that complex navigation is facilitated by spatial memory in a population of Chrysemys picta that navigate with extreme precision (±3.5 m) using specific routes that must be learned prior to age three. We used scopolamine, a muscarinic acetylcholine receptor antagonist, to manipulate the cognitive spatial abilities of free-living turtles during naturally occurring overland movements. Experienced adults treated with scopolamine diverted markedly from their precise navigation routes. Naive juveniles lacking experience (and memory) were not affected by scopolamine, and thereby served as controls for perceptual or non-spatial cognitive processes associated with navigation. Further, neither adult nor juvenile movement was affected by methylscopolamine, a form of scopolamine that does not cross the blood-brain barrier, a control for the peripheral effects of scopolamine. Together, these results are consistent with a role of spatial cognition in complex navigation and highlight a cellular mechanism that might underlie spatial cognition. Overall, our findings expand our understanding of the development of complex cognitive abilities of vertebrates and the neurological mechanisms of navigation.