This paper considers the results of experimental investigations that confirm the important role of sorption in phase transformations in the productive collector and the distribution of hydrocarbon components between stationary and recoverable parts of the system. Sorption of high-boiling components of the bedded hydrocarbon mixture on walls of pore channels can change the composition of a filtering fluid. A decrease in the cross section of filtration channels can be accompanied by reduction of bed permeability and, as a consequence, hydrocarbon output. This is especially true of the methodology of laboratory experimentation. Reduction of permeability due to adsorption during oil filtration in sandy collectors was reported in [1, 2] as far back as the 1940s. Formation of the adsorption bed in oil pools changes the molecular nature of the solid surface and produces a colloidal boundary layer of oil. Its viscosity is an order of magnitude higher compared to that of oil in the collector, and its thickness is commensurable in some cases with the radius of pore channels [3]. The authors of [4] demonstrated that the porous medium exerts a considerable influence on phase transformations, in particular, on the evaporation of retrograde condensate exuded in the bed during the injection of “dry” hydrocarbon gas into the bed model. Phenomena determined by the molecular interaction of fluids with pore walls play a great role in the gas condensate or oil bed that represents a highly dispersed porous medium with a developed surface. The mechanism of these phenomena is, however, insufficiently understood to be taken into account quantitatively in the development of hydrocarbon pools. This is particularly true for hydrocarbon pools put into operation in the Achimovian and Lower Cretaceous rocks of West Siberia.