The authors document a case of a 65-year-old heart transplant recipient at 10-year follow-up, with particular reference to his psychiatric recovery. This case illustrates the importance of social support as both an acute intervention and for long-term maintenance in the heart-transplant patient with psychiatric and multiple medical conditions. It was found that the influence of social support on transplant recovery may be affected by critical periods, including initial postoperative stabilization and convalescence, and then again with longer-term changes in social roles. Enhanced collaboration between cardiac transplant teams and mental health professionals is warranted.