Role In Quality Of Life Research Articles

The Impacts of Home Confinement Due To Coronavirus (COVID-19) on Children: A Cross Sectional Survey Study, Mediclinic City Hospital, Dubai, UAE

Children are developing individuals with countless factors affecting their growth and development, from genetics to parenting, schools, environments, nutrition, good habits of sleep and health. They are very sensitive individuals to sudden changes in routine. Schools represent life for them and a place of not only learning, but also social interaction and sensory neurodevelopment. Disasters and pandemics such as the existing situation of COVID-19 are a major cause of trauma affecting their education, play, mental health, physical health, vaccinations, sleep, and development. The governments’ strategies particularly home confinement and school closure to prevent the COVID-19 pandemic spread added unavoidable stress and psychosocial impacts on both adults and children. Trauma of this kind may endure for a long time with negative consequences that may manifest later on, even up to adult life. We conducted a cross sectional parental survey, to assess the impacts of home confinement on children in the cosmopolitan city of Dubai, UAE. Children included were from 3 years until 16 years old who were in schools or pre-school placements before COVID-19 started. Total number of children included in the survey was 658 of which 327 were boys and 331 girls. We found that the impact of the home confinement on children was significant and directly affected their quality of life (QoL) that may extend beyond the lockdown for longtime. This study will help relevant authorities and organizations to understand the negative impacts brought by the COVID-19 confinement on children and to adopt appropriate strategies to help children and their parents tackle these impacts and get them back to normal life and school again. This study also paved the way for future studies in the identification and management of children’s behavior, attention, education, and other factors that play active roles in QoL and normal development. Moreover, this study may help in embracing early preventative and management plans by schools and authorities in future similar pandemics, infections, disasters or school outbreaks. We also discuss strategies for school reopening and flexibility when an outbreak happens again in a school or community.

Gender role in anxiety, depression and quality of life in chronic kidney disease patients.

Objective:To investigate gender role in quality of life, anxiety, and depression in chronic kidney disease patients. The study hypothesized that men will score high on depression and, anxiety and will score low on quality of life and perceived social support as compare to womenMethods:One hundred patients with chronic kidney diseases were selected using purposive sampling strategy from nephrology ward of Leady Reading Hospital, Peshawar. The participants were included both male (n=50) and female (n=50) ranging in age from 18-65 years (M=44.16, SD= 15.15) Patients were recruited on the basis of preset inclusion criteria i-e (willing to participat, could read, speak and understand urdu language, with no previous history of dialysis treatment) and exclusion criteria (Age > than 18, Previous psychiatric history, Diagnosis less than one year, Education less than high school). All participants completed Quality of Life Questionnaire, Anxiety and depression questionnaires.Results:Statistical analysis of independent sample t-test shows significant difference of men and women on QOL t(98)=2.34,p=.021), anxiety t(98)=4.23,p=.001), and depression t(98)=4.54, p=.001) while no significant gender differences were reported on perceived social support t(98)= .98,p= .327.Conclusion:Male showed more depression, anxiety as compared to females while women reported poor quality of life as compared to men.

ROLE OF TOPICAL APPLICATION OF NANO SILVER ON ULCER HEALING: A COMPARATIVE STUDY

Background: The disruption of cellular flow of any tissue or its integrity cause wounds which associated with loss of function however, etiology is highly diverse. Among the etiological factors, they can be physical, chemical and surgical and even microbial injuries. Therefore, correction of damaged tissue or wound management plays a significant role in better quality of life to the patient
 Material & Methods: The present study was prospective comparative interventional study 100 Patients who had ulcers were enrolled from outdoor and from ward by simple random sampling. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant.
 Results: In the present study, among the povidone iodine group, 49 (98%) patients had slough on day 1st, 04 (8%) patients had slough after 1 week, 40 (80%) patients had slough after 2 weeks, 33 (66%) patients had slough after 3 weeks, 19 (38%) patients had slough after 4 weeks, 08 (16%) patients had slough after 5 weeks and 0 (0%) patients had slough after 6 weeks. In the nano silver group, 49 (98%) patients had slough on day 1st, 41 (82%) patients had slough after 1 week, 24 (48%) patients had slough after 2 weeks, 09 (18%) patients had slough after 3 weeks, 03 (06%) patients had slough after 4 weeks, 0 (0%) patients had slough after 5 weeks. We found statistically significant differences on the presence of slough after 2nd week onwards in both groups (p value < 0.05).
 Conclusions: We concluded from the present study that the topical application of nano silver gel for ulcer dressing shows faster and better healing in comparison to ulcer healing in povidone iodine group. In nano silver group 100% patients had granulation tissue by the end of 5th weeks and none of patients had slough by the end of 5th weeks.
 Key words: ulcer, healing, nano silver, povidone iodine.

Hemophilia and sexual health: results from the HERO and B-HERO-S studies.

BackgroundSexual health plays a primary role in quality of life (QoL) for many people, including those with hemophilia; however, there is little information available about sexual relationships and satisfaction in patients with hemophilia.MethodsTo address this issue, the Hemophilia Experiences, Results and Opportunities (HERO) and the Bridging Hemophilia B Experiences, Results and Opportunities into Solutions (B-HERO-S) studies included questions from the Male Sexual Health Questionnaire (MSHQ).ResultsAlthough these data were not statistically analyzed for comparisons between the 3 populations (HERO, HERO US only, and B-HERO-S), in general, participants in the HERO survey appeared to be more satisfied with their sexual relationship than participants in the B-HERO-S survey. In addition, many patients, especially those outside the United States, reported that they had not discussed sexual health with their doctor or other members of the hemophilia treatment center team. While the topic of sexual health has been infrequently explored in men with hemophilia, this is the first time it has been investigated in women with hemophilia.ConclusionThe results of these studies demonstrate that the impact of hemophilia extends to intimacy and suggest the need for large-scale studies in additional countries to explore further the factors associated with sexual health issues in people with hemophilia.

The self-perceptions of aging were an important factor associated with the quality of life in Chinese elderly with hypertension.

In China, quality of life (QOL) of the elderly with hypertension was lower than that of normal elderly and lower self-perceptions of aging (SPA) in the elderly with chronic diseases have been shown. Previous studies showed that SPA played a key role in QOL of the elderly. We hypothesised that SPA were associated with QOL in Chinese elderly with hypertension, with more negative SPA predicting lower QOL. A cross-sectional survey was conducted in one comprehensive hospital, 15 urban community clinics and 22 rural village clinics in Suzhou. In total, 1029 Chinese elderly with hypertension completed the self-administered questionnaires, including socio-demographic and clinical characteristics, aging perceptions questionnaire which contained seven dimensions and Medical Outcomes Study 36-item Short Form Health Survey evaluating QOL which included physical component summary (PCS) and mental component summary (MCS). Correlation analysis between SPA and QOL showed that most dimensions of SPA were correlated with PCS and MCS, except for Emotional Representations not correlated with MCS. The results of multivariate logistic regression analysis showed: the dimensions Timeline Chronic (B = -2.651, P < 0.001), Consequences Negative (B = -2.155, P < 0.001) and Emotional Representations (B = -2.672, P < 0.001) had a negative association with PCS, while Timeline Cyclical (B = 1.401, P = 0.023), Consequences Positive (B = 1.200, P = 0.011) and Control Positive (B = 1.425, P = 0.004) had a positive association with PCS; the dimensions Timeline Cyclical (B = -1.734, P < 0.001) and Consequences Negative (B = -1.646, P < 0.001) had a negative association with MCS, while Timeline Chronic (B = 1.313, P < 0.001), Consequences Positive (B = 0.962, P = 0.012), Control Positive (B = 2.453, P < 0.001) and Control Negative (B = 1.860, P < 0.001) had a positive association with MCS. Our results suggest that negative SPA tended to be associated with lower QOL in Chinese elderly with hypertension. Some measures to improve unhealthy negative SPA should be delivered to improve QOL in Chinese elderly with hypertension.

Quality of Life One Year After Bariatric Surgery: the Moderator Role of Spirituality.

This study aimed to assess quality of life in obese patients 1year after bariatric surgery taking into consideration the influence of socio-demographic, clinical, and psychological variables. A sample of 90 patients undergoing bariatric surgery was assessed in two moments: before surgery and 1year after surgery. Social support, problem-focused coping strategies, and quality of life increased after surgery, while eating disorder behaviour and impulsiveness decreased. The presence of eating disorder behaviour predicted worse physical and mental quality of life and higher satisfaction with social support predicted better physical and mental quality of life. In addition, higher impulsiveness predicted worse mental quality of life. Spirituality moderated the relationship between impulsiveness and mental/physical quality of life. Interventions should focus on promoting social support and coping strategies particularly spirituality since it played an important role in quality of life.

QUALITY OF LIFE IN PATIENTS WITH MYELOPROLIFERATIVE NEOPLASMS (REVIEW)

The target drugs use showed high efficiency and raised the patients’ life expectancy approaching it to average on population and became the new era in hematooncology. Given the currant tendency, the investigation of problems of patients’ quality of life and the affecting factors is actual. We have analyzed the modern foreign and domestic literature data concerning the quality of life of patients with myeloproliferative diseases and their variation principal causes and parameters reflecting the phenomenon. Also, we state the basic information on diseases where the myeloid lineage hyperplasia is the root cause. The pathophysiological and clinical features of the blood system pathologies are specified. The high-priority factors influencing quality of life of patients with myeloproliferative diseases are highlighted. The basic mechanisms of cardiovascular and thrombotic events development, playing a key role in the patients quality of life forming are in more detail described on the example of chronic myeloid leukemia and polycythemia vera. Moreover, the expediency of search of new diagnostic approaches to the assessment of myeloproliferative diseases course and the patients’ quality of life on a background of modern therapy have been shown.

PO-004 The influence of lifestyle on the quality of life of breast cancer patients

Objective To explore the effects of healthy lifestyle such as exercise and diet on health-related quality of life in patients with breast cancer. &#x0D; Methods 427 breast cancer patients who met the inclusion criteria were investigated and analyzed. All the patients were collected in the department of oncology of a third-class first-class hospital from January 1, 2015 to June 30, 2016.&#x0D; The cancer treatment quality of life core scale (EORTC QLQ-C30) and cancer treatment function evaluation system scale (FACT-B) were used to investigate and collect the questionnaire for statistical analysis of all data.&#x0D; Results The scores of health-related quality of life were higher in regular exercise than those in non-regular exercise. Patients who ate more than 300g of vegetables per day had higher health-related quality of life scores. The scores of health-related quality of life were higher in patients who ate more than 200g fruit per day (p&lt;0.05). Patients with two healthy lifestyles had higher health-related quality of life scores than patients with one healthy lifestyle (p&lt;0.05).&#x0D; Conclusions Multi-frequency exercise and adequate intake of vegetables and fruits play a positive role in the health-related quality of life of breast cancer patients. Breast cancer patients with two healthy lifestyles had significantly better health-related quality of life than patients with one healthy lifestyle. Healthy lifestyle with adequate exercise and adequate intake of fruits and vegetables should be paid more attention to in improving the health-related quality of life of breast cancer patients.

Rehabilitation for patients with sepsis: A systematic review and meta-analysis.

The objective of this systematic review was to determine whether rehabilitation impacts clinically relevant outcomes among adult patients with sepsis. Randomized controlled trials from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PEDro, and the World Health Organization International Clinical Trials Platform Search Portal, as well as conference proceedings and reference lists of relevant articles were collected. Two reviewers independently identified randomized controlled trials on the rehabilitation of patients with sepsis, and the two reviewers independently abstracted trial level data including population characteristics, interventions, comparisons, and clinical outcomes. Our primary outcomes were quality of life (QOL), activity of daily living (ADL), and mortality. Our secondary outcomes were length of stay, return to work, muscle strength, delirium, and all adverse events. The quality of evidence was determined using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. We included two trials enrolling 75 patients. The mean difference (95% confidence interval [CI]) of physical function and physical role in QOL measured by SF-36 were 21.10 (95% CI: 6.57–35.63) and 44.40 (95% CI: 22.55–66.05), respectively. Rehabilitation did not significantly decrease intensive care unit (ICU) mortality (risk ratio, 2.02 [95% CI: 0.46–8.91], I2 = 0%; n = 75). ICU length of stay and hospital length of stay and muscle strength were not statistically significantly different and no adverse events were reported in both studies. The certainty of the evidence for these outcomes was “very low.” Data on ADL, return to work, and delirium were not available in any of the trials. Rehabilitation of patients with sepsis might not decrease ICU mortality, but might improve QOL. Further, well-designed trials measuring important outcomes will be needed to determine the benefit and harm of rehabilitation among patients with sepsis.

Mo1505 - Esophageal Hypersensitivity Plays a Role in Quality of Life and Symptom Scores Following Treatment for Achalasia

Mo1505 - Esophageal Hypersensitivity Plays a Role in Quality of Life and Symptom Scores Following Treatment for Achalasia

Quality of Life in Gulf War Veterans: the Influence of Recency and Persistence of Psychiatric Morbidity

Important contributors to quality of life (QOL), such as psychosocial factors, have received limited exploration in veteran populations, in contrast to a significant amount of research focused on health-related quality of life (HRQL). This study investigated QOL and HRQL amongst Gulf War veterans compared with an era-military comparison group 20 years after the 1990/91 Gulf War, and whether psychiatric status over time and psychiatric comorbidities predicted QOL and HRQL. We then investigated which of a range of psychological health, physical health and social factors contribute greatest to QOL. Psychological interviews and postal questionnaires were administered to a cohort of Gulf War veterans and a military-era comparison group in 2000–02 and 2011–12. Gulf War veterans had poorer QOL and HRQL compared with a military comparison group, but the pattern of factors that influenced QOL was the same for both groups. Poorer QOL and HRQL were significantly associated with more recent and persistent psychiatric morbidity over time. Further analyses showed that affective disorders, followed by anxiety disorders had the largest impact on QOL and HRQL, and that QOL and HRQL were negatively affected by each additional psychiatric diagnosis. The importance of these findings was highlighted in a structural equation model that revealed psychological health contributed most to QOL, social support contributed a moderate amount, but physical health contributed only a very small amount. QOL in veterans is an important issue even many years after deployment and psychological health plays a predominant role in QOL.

Restless Legs Syndrome in Iranian People With Type 2 Diabetes Mellitus: The Role in Quality of Life and Quality of Sleep.

To investigate the prevalence of restless legs syndrome (RLS) in patients with type 2 diabetes mellitus (T2DM) and explore its role in quality of life (QoL) and quality of sleep of these patients. This is a cross-sectional study performed on 210 Iranian people with T2DM. The diagnosis of RLS was established based on the essential diagnostic criteria for RLS recommended by the National Institutes of Health. Sleep quality and QoL were assessed in all participants using Pittsburgh Sleep Quality Index and EuroQol five-dimension questionnaire, respectively. Regression models were used for final analysis of data. The prevalence of RLS was 19.5%; of whom 38.1% had poor quality of sleep. Male sex, being single, body mass index (BMI), and RLS were associated with poor quality of sleep. Patients with RLS were almost three times as likely as the patients without RLS to have poor sleep quality. Moreover, being female, BMI value, level of glycosylated hemoglobine (HbA1C), and RLS were associated with lower QoL. RLS lowers the score of QoL even more than BMI and HbA1C. In addition, the QoL and sleep quality of this population of patients with diabetes have not been affected by the severity of RLS as well as presence or absence of neuropathy. RLS has an independent and significant role in sleep quality and QoL in the patients with diabetes. Neuropathy with RLS does not confer any additive burden on QoL and sleep quality of this population of patients with diabetes.

Predicting health-related quality of life in cancer patients receiving chemotherapy: a structural equation approach using the self-control model

BackgroundAccording to the self-control model, self-control works as a protective factor and a psychological resource. Although an understanding of the effect(s) of peripheral neuropathy on quality of life is important to healthcare professionals, previous studies do not facilitate broad comprehension in this regard. The purpose of this cross-sectional study was to test the multidimensional assumptions of quality of life of patients with cancer, with focus on their self-control.MethodsA structural equation model was tested on patients with cancer at the oncology clinic of a university hospital where patients received chemotherapy. A model was tested using structural equation modeling, which allows the researcher to find the empirical evidence by testing a measurement model and a structural model. The model comprised three variables, self-control, health related quality of life, and chemotherapy-induced peripheral neuropathy. Among the variables, self-control was the endogenous and mediating variable.ResultsThe proposed models showed good fit indices. Self-control partially mediated chemotherapy-induced peripheral neuropathy and quality of life. It was found that the physical symptoms of peripheral neuropathy influenced health-related quality of life both indirectly and directly.ConclusionsSelf-control plays a significant role in the protection and promotion of physical and mental health in various stressful situations, and thus, as a psychological resource, it plays a significant role in quality of life. Our results can be used to develop a quality of life model for patients receiving chemotherapy and as a theoretical foundation for the development of appropriate nursing interventions.

Perceived social support in African American breast cancer patients: Predictors and effects

RationaleSocial support plays an important role in quality of life and health outcomes after breast cancer diagnosis and treatment. ObjectiveTo examine changes in perceived social support in African American women during the two years following a new breast cancer diagnosis. MethodsThis secondary analysis uses data collected from 2009 to 2015 from 227 newly diagnosed, African American women with breast cancer (mean age 56 [SD = 10], 59% household income < $25,000; 28% married/partnered, 72% early stage) participating in a randomized controlled trial testing the effects of a video-communication intervention on quality-of-life and follow-up care. Participants, all of whom received treatment in one metropolitan area of the Midwestern United States, completed five telephone interviews over 2-year follow-up; demographic, psychosocial, quality of life, and clinical data were collected. Growth curve models were used to examine change in perceived social support (measured by the Medical Outcomes Study Social Support Survey) as well as correlates of baseline levels of social support and predictors of change in individuals’ social support. Additional analyses examined whether change in social support over the first year affected depressive symptoms (Center for Epidemiologic Studies Depression Scale) and general health perceptions (RAND SF-36 subscale) at two years. ResultsBeing married, reporting greater spirituality, and reporting fewer depressive symptoms at baseline were significantly associated with higher initial levels of perceived social support. Women whose social support declined during the first year after diagnosis reported more severe depressive symptoms and worse general health perceptions at two years. ConclusionClinicians should periodically assess perceived social support among African American women with breast cancer to help find support resources for those who have low initial social support and for those whose support declines in the first year after diagnosis.

Predictors of quality of life and survival following Gamma Knife surgery for lung cancer brain metastases: a prospective study.

OBJECTIVE Lung cancer (LC) patients who develop brain metastases (BMs) have a poor prognosis. Estimations of survival and risk of treatment-related deterioration in quality of life (QOL) are important when deciding on treatment. Although we know of several prognostic factors for LC patients with BMs, the role of QOL has not been established. Authors of this study set out to evaluate changes in QOL following Gamma Knife surgery (GKS) for BMs in LC patients and QOL as a prognostic factor for survival. METHODS Forty-four of 48 consecutive LC patients with BMs underwent GKS in the period from May 2010 to September 2011, and their QOL was prospectively assessed before and 1, 3, 6, 9, and 12 months after GKS by using the Functional Assessment of Cancer Therapy-Brain (FACT-BR) questionnaire. A mixed linear regression model was used to identify potential predictive factors for QOL and to assess the effect of GKS and the disease course on QOL at follow-up. RESULTS Mean QOL as measured by the brain cancer subscale (BRCS) of the FACT-BR remained stable from baseline (score 53.0) up to 12 months post-GKS (57.1; p = 0.624). The BRCS score improved for 32 patients (72.3%) with a total BM volume ≤ 5 cm3. Mean improvement in these patients was 0.45 points each month of follow-up, compared to a decline of 0.50 points each month despite GKS treatment in patients with BM volumes > 5 cm3 (p = 0.04). Asymptomatic BMs (p = 0.01), a lower recursive partitioning analysis (RPA) classification (p = 0.04), and a higher Karnofsky Performance Scale (KPS) score (p < 0.01) at baseline were predictors for a high, stable QOL after GKS. After multivariate analysis, a high KPS score (p < 0.01) remained the only positive predictor of a high, stable QOL post-GKS. Median survival post-GKS was 5.6 months (95% CI 1.0-10.3). A higher BRCS score (p = 0.01), higher KPS score (p = 0.01), female sex (p = 0.01), and the absence of liver (p = 0.02), adrenal (p = 0.02), and bone metastases (p = 0.03) predicted longer survival in unadjusted models. However, in multivariate analyses, a higher BRCS score (p < 0.01), female sex (p = 0.01), and the absence of bone metastases (p = 0.02) at GKS remained significant predictors. Finally, the BRCS score's predictive value for survival was compared with the values for the variables behind well-known prognostic indices: age, KPS score, extracranial disease status, and number and volume of BMs. Both BRCS score (p = 0.01) and BM volume (p = 0.05) remained significant predictors for survival in the final model. CONCLUSIONS Patient-reported QOL according to the BRCS is a predictor of survival in patients with BMs and may be helpful in deciding on the optimal treatment. Gamma Knife surgery is a safe and effective therapeutic modality that improves QOL for LC patients with a BM volume ≤ 5 cm3 at treatment. Careful follow-up and salvage therapy on demand seem to prevent worsening of QOL due to relapse of BMs.

The Role of Neuroticism and Psychological Flexibility in Chronic Fatigue and Quality of Life in Patients with Type 2 Diabetes

Abstract Background and Aims: The purpose of this study was to identify the role of neuroticism and psychological flexibility (PF) in quality of life (QOL) and chronic fatigue (CF) in patients with Type 2 Diabetes Mellitus (T2DM). Materials and Methods: We considered the all of the patients with T2DM over aged 30 years and living in the province of Hamadan, Iran in 2014 that were referred to the Hamadan Diabetes Center. A sample size of 170 patients was selected by the simple random sampling method. The measuring tools were completed by the patients. To test assumptions, the Pearson correlation and structural equation modeling were used. Results: The results showed that the correlation coefficient between neuroticism, with CF (r=0.579; p&lt;0.001) and QOL (r=-0.242; p&lt;0.001), and also correlation between PF and CF (r=0.287; p&lt;0.001) are significant. There is no significant relationship between QOL and PF (r= -0.098; p=0.203). Structural equation modeling showed that neuroticism has a direct positive effect in CF (p&lt;0.001) and a negative effect on QOL (p&lt;0.001), and the PF has a significant direct effect on CF (p=0.014) and an indirect effect on QOL. The CF affects negatively on the QOL (p&lt;0.001). Conclusion: It could be concluded that neuroticism and PF play important roles in QOL and CF and with effective intervention can help patients with diabetes to improve them QOL.

Relationship between sleep quality and mental health according to demographics of 850 patients with chronic obstructive pulmonary disease.

We aimed to study sleep problems in hospitalized chronic obstructive pulmonary disease patients and assess the relationship of sleep quality with mental health and demographics of patients. Our study sample consisted of 850 chronic obstructive pulmonary disease patients hospitalized in Masih Daneshvari Hospital. Demographic data were collected and the Pittsburgh Sleep Quality and mental health questionnaires were filled out for patients. The results showed that 5.9 percent were suffering from severe sleep problems, while 4.7 percent had severe mental problems. A strong positive correlation was found between the total scores of mental health and sleep quality ( p < 0.01). The prevalence of sleep and mental health problems was higher in females compared to males. Mental health and sleep quality play important roles in quality of life of chronic obstructive pulmonary disease patients.

Rotigotine Improve ThoracoAbdominal Movement in Elderly Patients with Vascular Parkinsonism Post-Stroke: A Statistical Observation about the Reduction of the Obstructive Sleep Apnoea Syndrome Index

Parkinsons disease and Vascular Parkinsonism are a frequent an underestimated disease in diseased people that play an important role in quality of life. They can be due to ischemic stroke in the area of the basal ganglia in patients with cardiovascular risk factors or brain lesions of the periventricular white substance. This disease reduces the motor symptoms, often causing diffused tremor (i.e. head, arms and legs) due to reduce level of endogenous dopamine. Also, in frailty patients there is a high incidence of breath and sleep disorder. Sleep respiratory disorders are one of the most frequent conditions in elderly patients with frailty, but often understimated. Respiratory disorders are distinguished in 3 items: peripheral, central and mixed. This classification is based on polisomnographic test. In a frailty patient’s group we have used this method to asses the possible correlation between ischemic stroke and correlated dopaminergic deficit that determines a complications of motor symptoms (extra-pyramidal syndrome and bradikinesia) and a worsening of the obstructive sleep apnoea syndrome (OSAS). We have enrolled 30 patients (13 male and 17 female with range age 60–92 years) who underwent polysomnografic test measuring thoraco-abdominal movement before and after a continuous and constant dopaminergic therapy in 24 hours. Analogly we have evaluated the oxygen saturation and the number of OSAS events/hour. Some data in licterature report that the reduction of the dopaminergic level can determinated muscular dyssynchrony that worsens respiratory activity and osas. Our data show that continuous and constant dopaminergic stimulation through Rotigotine transdermal patch improves thoraco-abdominal movements and therefore the OSAS index. Our data give comfortable results but further investigation is needed to have conclusive results.

The relationship between quality of life and social support among adolescents

Social support plays an important role in quality of life. The social support given to adolescents is thought to positively affect identity development and life quality as well as physical and psychosocial health. In this context, this study aims to examine the relationship between adolescents’ quality of life and social support levels. Designed as a relational screening model, the study was conducted at 5 secondary schools with 436 voluntarily participating students in Dulkadiroglu, Kahraman Maras during the 2016-2017 academic year. Within the study, the “Life Quality Scale for Children” and the “Social Relationship Principles Scale for Adolescents” was implemented. In the data analysis process, descriptive statistics, multiple regression analysis and Pearson Product-Moment Correlation analysis tests were used. According to the study results, a positive relationship was found between friends and family support and physical health, psychosocial health and quality of life.

The clinical potential of low-level C-peptide secretion

ABSTRACTIntroduction: In all forms of diabetes, especially so in Type 1 diabetes (T1D), beta cell function is crucial for the course. The interest for residual beta cell function has been meagre, but increased in recent years with interventions to preserve function.Areas covered: Importance and clinical use of C-peptide in Type 1 diabetes. Data for this review were identified by searches of PubMed, and references from relevant articles using the search terms: “type 1 diabetes”, “C-peptide”, “beta cell function”, “HbA1c”, quality of life”, “complications”. s and reports from meetings were not included.Expert commentary: C-peptide may help to get a correct diagnosis, and it is of practical clinical value to know degree of residual insulin secretion to diminish the risk of severe hypoglycaemia and ketoacidosis. Evidence shows that even a quite reduced beta cell function may play an important role for quality of life, for metabolic balance/control, possibility to avoid complications and even for long-term survival. Furthermore, the evidence is increasing for C-peptide being a hormone per se.