INTRODUCTIONProactive behavior shows promise in the challenges of midwifery students in adapting quickly and effectively to different clinical settings. The antecedents of rolebreadth self-efficacy, control appraisal and trust in peers have demonstrated a potential for significant benefit to proactive behavior in midwifery education. A new midwifery educational program, ‘PROMIsE’, was developed to influence these antecedents and so enhance proactive behavior.METHODSA pre-test/post-test cohort study of midwifery students’ antecedents in proactive behavior will be conducted from September 2018 until June 2022. All new starting midwifery students (n = estimated at 150) at one Belgian University College will be included. Data will be collected using a validated questionnaire at four time points: the entry point in the new midwifery curriculum, after one year, two years and at the end of the curriculum. A proportional odds logistic regression analysis will be used to clarify the association between these antecedents and the probability to observe proactive behavior within this group at different time points.RESULTSA historical comparison will be made with this cohort study and two previous cross-sectional studies. With ‘PROMIsE’ it is assumed that this cohort, which underwent the intervention of ‘PROMIsE’, will score significantly higher than the cross-sectional study groups.CONCLUSIONS‘PROMIsE’ aims to support the individual guidance of midwifery students towards proactive behavior in midwifery in order to cope with the numerous challenges in reproductive healthcare.