The triggering of slope failures can cause a significant impact on human settlements and infrastructure in cities, coasts, islands and mountains. Therefore, a reliable evaluation of the landslide hazard would help mitigate the effects of such landslides and decrease the relevant risk. The goal of this paper is to develop, for the first time on a regional scale (1:100,000), a landslide susceptibility map for the entire area of the Attica region in Greece. In order to achieve this, a database of slope failures triggered in the Attica Region from 1961 to 2020 was developed and a semi-quantitative heuristic methodology called Rock Engineering System (RES) was applied through an interaction matrix, where ten parameters, selected as controlling factors for the landslide occurrence, were statistically correlated with the spatial distribution of slope failures. The generated model was validated by using historical landslide data, field-verified slope failures and a methodology developed by the Oregon Department of Geology and Mineral Industries, showing a satisfactory correlation between the expected and existing landslide susceptibility level. Having compiled the landslide susceptibility map, studies focusing on landslide risk assessment can be realized in the Attica Region.