The main purpose of this study is to provide a digital drilling-based method for determining rock elastic modulus and evaluating the anisotropy. By considering a concept of crushed zone, the drilling response was characterized as the function of specific energy and drilling strength. On this basis, an equivalent elastic modulus was proposed to evaluate the rock elastic modulus. Moreover, an anisotropy index was proposed according to the difference in specific energy under different borehole directions. Digital drilling experiments were conducted for three lithologies at drilling directions namely 0, 60, and 120° (Based on vertical orientation), revealing the anisotropic effect exhibited in the rock. To validate the measurement of rock elastic modulus and its anisotropy, the compressive tests under same conditions were carried out. The results suggested that the proposed indicator provided an accurate evaluation for the rock's elastic modulus, with an error margin of less than 10%. Drilling-based anisotropy is identified in the drilling response, especially the critical state between cutting and friction. The statical indicator CoV (coefficient of variation) was utilized to characterize the anisotropy along the borehole. This research's innovation lies in providing an approach to evaluating rock anisotropy and determining its elastic modulus by considering the drilling response.