Pre-operative risk assessment remains a challenge in spinal fusion operations. Predictive modeling provides data-driven estimates of post-surgical outcomes, guiding clinical decisions and improving patient care. Moreover, automated machine learning models are both effective and user-friendly, allowing healthcare professionals with minimal technical expertise to identify high-risk patients who may need additional pre-operative support. This study investigated the use of automated machine learning models to predict discharge disposition, length of hospital stay, and readmission post-surgery by analyzing pre-operative patient electronic medical record data and identifying key factors influencing adverse outcomes. Retrospective cohort study. The sample includes electronic medical records of 3,006 unique surgical events from 2,855 patients who underwent lumbar spinal fusion surgeries at a single institution. The adverse outcomes assessed were discharge disposition (non-home facility), length of hospital stay (extended stay), and readmission within 90 days post-surgery. We employed several inferential and predictive approaches, including the automated machine learning tool TPOT2 (Tree-based Pipeline Optimization Tool-2). TPOT2, which uses genetic programming to select optimal machine learning pipelines in a process inspired by molecular evolution, constructed, optimized and identified robust predictive models for all outcomes. Feature importance values were derived to identify major pre-operative predictive features driving optimal models. Adverse outcome rates were 25.9% for discharge to non-home facilities, 23.9% for extended hospital stay, and 24.7% for readmission within 90 days post-surgery. TPOT2 delivered the best-performing predictive models, achieving balanced accuracies ((Sensitivity [true positive rate] + Specificity [true negative rate)]) / 2) of 0.72 for discharge disposition, 0.72 for length of stay, and 0.67 for readmission. Notably, preoperative hemoglobin emerged as a consistently strong predictor in best-performing models across outcomes. Patients with severe anemia (hemoglobin <80g/dL) demonstrated higher associations with all adverse outcomes and common comorbidities associated with frailty (e.g., hypertension, type II diabetes, and chronic pain). Additional patient variables and comorbidities, including body mass index, age, and mental health status, influencing post-surgical outcomes were also highly predictive. This study demonstrates the effectiveness of automated machine learning in predicting post-surgical adverse outcomes and identifying key pre-operative predictors associated with such outcomes. While factors like age, BMI, insurance type, and specific comorbidities showed notable effects on outcomes, preoperative hemoglobin consistently emerged as a significant predictor across outcomes, suggesting its critical role in pre-surgical assessment. These findings underscore the potential of enhancing patient care and preoperative assessment through advanced predictive modeling.
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